New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review

Postoperative pain is prevalent and often undertreated. There is a risk that untreated or suboptimally treated postoperative pain may transition into chronic postoperative pain, which can be challenging to treat. Clinical guidelines recommend the use of multimodal analgesia, including non-steroidal...

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Autores: Mayoral Rojals, Victor, Charaja, Moises, De Leon Casasola, Oscar, Montero Matamala, Antonio, Narvaez Tamayo, Marco Antonio, Varrassi, Giustino
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/84874
Acceso en línea:https://doi.org/10.7759/cureus.23037
http://hdl.handle.net/10459.1/84874
Access Level:acceso abierto
Palabra clave:Preemptive analgesia
Opioids
Multimodal analgesia
Postoperative pain
Analgesia
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spelling New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative ReviewMayoral Rojals, VictorCharaja, MoisesDe Leon Casasola, OscarMontero Matamala, AntonioNarvaez Tamayo, Marco AntonioVarrassi, GiustinoPreemptive analgesiaOpioidsMultimodal analgesiaPostoperative painAnalgesiaPostoperative pain is prevalent and often undertreated. There is a risk that untreated or suboptimally treated postoperative pain may transition into chronic postoperative pain, which can be challenging to treat. Clinical guidelines recommend the use of multimodal analgesia, including non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and, in some cases, opioids. NSAIDs are a broad class of drugs with different attributes such as cyclo-oxygenase (COX)-1 or COX-2 selectivity, onset of action, and analgesic potency. NSAIDs are associated with gastrointestinal and cardiovascular side effects and should be administered at the lowest effective dose for the shortest effective duration but can be effective in postoperative pain. The role of opioids in postoperative analgesia is long-standing but has recently come under scrutiny. Opioids are often used in multimodal analgesic combinations in such a way as to minimize the total consumption of opioids without sacrificing analgesic benefit. Special clinical considerations are required for surgical patients already on opioid regimens or with opioid use disorder. A particularly useful fixed-dose combination product for postoperative analgesia is dexketoprofen-tramadol, which confers safe and effective postoperative pain control and reduces the risk of persistent postoperative pain.Cureus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.7759/cureus.23037http://hdl.handle.net/10459.1/84874http://hdl.handle.net/10459.1/84874reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.7759/cureus.23037Cureus, 2022, vol. 14, núm. 3, art. 23037.cc-by (c) Victor Mayoral Rojals et. al., 2022.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/848742026-05-29T05:05:01Z
dc.title.none.fl_str_mv New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
title New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
spellingShingle New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
Mayoral Rojals, Victor
Preemptive analgesia
Opioids
Multimodal analgesia
Postoperative pain
Analgesia
title_short New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
title_full New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
title_fullStr New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
title_full_unstemmed New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
title_sort New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review
dc.creator.none.fl_str_mv Mayoral Rojals, Victor
Charaja, Moises
De Leon Casasola, Oscar
Montero Matamala, Antonio
Narvaez Tamayo, Marco Antonio
Varrassi, Giustino
author Mayoral Rojals, Victor
author_facet Mayoral Rojals, Victor
Charaja, Moises
De Leon Casasola, Oscar
Montero Matamala, Antonio
Narvaez Tamayo, Marco Antonio
Varrassi, Giustino
author_role author
author2 Charaja, Moises
De Leon Casasola, Oscar
Montero Matamala, Antonio
Narvaez Tamayo, Marco Antonio
Varrassi, Giustino
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Preemptive analgesia
Opioids
Multimodal analgesia
Postoperative pain
Analgesia
topic Preemptive analgesia
Opioids
Multimodal analgesia
Postoperative pain
Analgesia
description Postoperative pain is prevalent and often undertreated. There is a risk that untreated or suboptimally treated postoperative pain may transition into chronic postoperative pain, which can be challenging to treat. Clinical guidelines recommend the use of multimodal analgesia, including non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and, in some cases, opioids. NSAIDs are a broad class of drugs with different attributes such as cyclo-oxygenase (COX)-1 or COX-2 selectivity, onset of action, and analgesic potency. NSAIDs are associated with gastrointestinal and cardiovascular side effects and should be administered at the lowest effective dose for the shortest effective duration but can be effective in postoperative pain. The role of opioids in postoperative analgesia is long-standing but has recently come under scrutiny. Opioids are often used in multimodal analgesic combinations in such a way as to minimize the total consumption of opioids without sacrificing analgesic benefit. Special clinical considerations are required for surgical patients already on opioid regimens or with opioid use disorder. A particularly useful fixed-dose combination product for postoperative analgesia is dexketoprofen-tramadol, which confers safe and effective postoperative pain control and reduces the risk of persistent postoperative pain.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.7759/cureus.23037
http://hdl.handle.net/10459.1/84874
http://hdl.handle.net/10459.1/84874
url https://doi.org/10.7759/cureus.23037
http://hdl.handle.net/10459.1/84874
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.7759/cureus.23037
Cureus, 2022, vol. 14, núm. 3, art. 23037.
dc.rights.none.fl_str_mv cc-by (c) Victor Mayoral Rojals et. al., 2022.
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Victor Mayoral Rojals et. al., 2022.
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cureus
publisher.none.fl_str_mv Cureus
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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