LYP regulates SLP76 and other adaptor proteins in T cells

[Background]: The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about...

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Detalles Bibliográficos
Autores: Ruiz-Martín, Virginia, Marcos de Mena, Tamara, Pereda, José M. de, Sánchez Crespo, Mariano, Fuente, Miguel A. de la, Bayón, Yolanda, Alonso, Andrés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/380259
Acceso en línea:http://hdl.handle.net/10261/380259
Access Level:acceso abierto
Palabra clave:Protein tyrosine phosphatase (PTP)
LYP (lymphoid phosphatase)
Tcell
Tcell receptor (TCR)
SLP76
SKAP2
FYB
Descripción
Sumario:[Background]: The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about LYP substrates is in part responsible for the poor understanding of LYP function.

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