A genome-wide association study of total child psychiatric problems scores

Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric p...

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Detalhes bibliográficos
Autores: Neumann, Alexander, Vilor Tejedor, Natàlia, 1988-, Alemany, Silvia, Sunyer Deu, Jordi, Tiemeier, Henning
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/54722
Acesso em linha:http://hdl.handle.net/10230/54722
http://dx.doi.org/10.1371/journal.pone.0273116
Access Level:acceso abierto
Palavra-chave:Human genetics
Genome-wide association studies
Clinical genetics
Single nucleotide polymorphisms
Gene expression
ADHD
Metaanalysis
Genetic loci
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spelling A genome-wide association study of total child psychiatric problems scoresNeumann, AlexanderVilor Tejedor, Natàlia, 1988-Alemany, SilviaSunyer Deu, JordiTiemeier, HenningHuman geneticsGenome-wide association studiesClinical geneticsSingle nucleotide polymorphismsGene expressionADHDMetaanalysisGenetic lociSubstantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.The work of H. Tiemeier is further supported by a European Union’s Horizon 2020 research and innovation program (Contract grant number: 633595, DynaHealth) and a NWO-VICI grant (NWO-ZonMW: 016.VICI.170.200). https://www.nwo.nl/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of Science (PLoS)202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/54722http://dx.doi.org/10.1371/journal.pone.0273116reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésPLoS One. 2022 Aug 22;17(8):e0273116info:eu-repo/grantAgreement/EC/H2020/633595© 2022 Neumann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/547222026-06-12T07:21:37Z
dc.title.none.fl_str_mv A genome-wide association study of total child psychiatric problems scores
title A genome-wide association study of total child psychiatric problems scores
spellingShingle A genome-wide association study of total child psychiatric problems scores
Neumann, Alexander
Human genetics
Genome-wide association studies
Clinical genetics
Single nucleotide polymorphisms
Gene expression
ADHD
Metaanalysis
Genetic loci
title_short A genome-wide association study of total child psychiatric problems scores
title_full A genome-wide association study of total child psychiatric problems scores
title_fullStr A genome-wide association study of total child psychiatric problems scores
title_full_unstemmed A genome-wide association study of total child psychiatric problems scores
title_sort A genome-wide association study of total child psychiatric problems scores
dc.creator.none.fl_str_mv Neumann, Alexander
Vilor Tejedor, Natàlia, 1988-
Alemany, Silvia
Sunyer Deu, Jordi
Tiemeier, Henning
author Neumann, Alexander
author_facet Neumann, Alexander
Vilor Tejedor, Natàlia, 1988-
Alemany, Silvia
Sunyer Deu, Jordi
Tiemeier, Henning
author_role author
author2 Vilor Tejedor, Natàlia, 1988-
Alemany, Silvia
Sunyer Deu, Jordi
Tiemeier, Henning
author2_role author
author
author
author
dc.subject.none.fl_str_mv Human genetics
Genome-wide association studies
Clinical genetics
Single nucleotide polymorphisms
Gene expression
ADHD
Metaanalysis
Genetic loci
topic Human genetics
Genome-wide association studies
Clinical genetics
Single nucleotide polymorphisms
Gene expression
ADHD
Metaanalysis
Genetic loci
description Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/54722
http://dx.doi.org/10.1371/journal.pone.0273116
url http://hdl.handle.net/10230/54722
http://dx.doi.org/10.1371/journal.pone.0273116
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS One. 2022 Aug 22;17(8):e0273116
info:eu-repo/grantAgreement/EC/H2020/633595
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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