Selection on coding regions determined <i>Hox7</i> genes evolution

The important role of Hox genes in determining the regionalization of the body plan of the vertebrates makes them invaluable candidates for evolutionary analyses regarding functional and morphological innovation. Gene duplication and gene loss. led to a variable number of Hox genes in different vert...

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Detalles Bibliográficos
Autores: Fares, MA, Bezemer, D, Moya, A, Marín, I
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p17213
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/17213
Access Level:acceso abierto
Palabra clave:gene duplication
homeotic genes
homeobox
mutual information
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spelling Selection on coding regions determined <i>Hox7</i> genes evolutionFares, MABezemer, DMoya, AMarín, Igene duplicationhomeotic geneshomeoboxmutual informationThe important role of Hox genes in determining the regionalization of the body plan of the vertebrates makes them invaluable candidates for evolutionary analyses regarding functional and morphological innovation. Gene duplication and gene loss. led to a variable number of Hox genes in different vertebrate lineages. The evolutionary forces determining the conservation or loss of Hox genes are poorly understood. In this study, we show that variable selective pressures acted on Hox7 genes in different evolutionary lineages, with episodes of positive selection occurring after gene duplications. Tests for functional divergence in paralogs detected significant differentiation in a region known to modulate HOX7 protein activity. Our results show that both positive and negative selection on coding regions are influencing Hox7 genes evolution.Oxford University Press2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/17213MOLECULAR BIOLOGY AND EVOLUTIONISSN: 15371719ISSNe: 07374038reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p172132026-06-11T12:45:17Z
dc.title.none.fl_str_mv Selection on coding regions determined <i>Hox7</i> genes evolution
title Selection on coding regions determined <i>Hox7</i> genes evolution
spellingShingle Selection on coding regions determined <i>Hox7</i> genes evolution
Fares, MA
gene duplication
homeotic genes
homeobox
mutual information
title_short Selection on coding regions determined <i>Hox7</i> genes evolution
title_full Selection on coding regions determined <i>Hox7</i> genes evolution
title_fullStr Selection on coding regions determined <i>Hox7</i> genes evolution
title_full_unstemmed Selection on coding regions determined <i>Hox7</i> genes evolution
title_sort Selection on coding regions determined <i>Hox7</i> genes evolution
dc.creator.none.fl_str_mv Fares, MA
Bezemer, D
Moya, A
Marín, I
author Fares, MA
author_facet Fares, MA
Bezemer, D
Moya, A
Marín, I
author_role author
author2 Bezemer, D
Moya, A
Marín, I
author2_role author
author
author
dc.subject.none.fl_str_mv gene duplication
homeotic genes
homeobox
mutual information
topic gene duplication
homeotic genes
homeobox
mutual information
description The important role of Hox genes in determining the regionalization of the body plan of the vertebrates makes them invaluable candidates for evolutionary analyses regarding functional and morphological innovation. Gene duplication and gene loss. led to a variable number of Hox genes in different vertebrate lineages. The evolutionary forces determining the conservation or loss of Hox genes are poorly understood. In this study, we show that variable selective pressures acted on Hox7 genes in different evolutionary lineages, with episodes of positive selection occurring after gene duplications. Tests for functional divergence in paralogs detected significant differentiation in a region known to modulate HOX7 protein activity. Our results show that both positive and negative selection on coding regions are influencing Hox7 genes evolution.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/17213
url https://fisabio.portalinvestigacion.com/publicaciones/17213
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv MOLECULAR BIOLOGY AND EVOLUTION
ISSN: 15371719
ISSNe: 07374038
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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