Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.

Background: Pneumonia remains a major cause of morbidity and mortality among critically ill children. Lung ultrasound has emerged as a promising bedside diagnostic tool. Methods: A systematic review and meta-analysis across PubMed, Embase, The Cochrane Library, Scopus, World Health Organization Libr...

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Authors: Guitart C, Becerra-Hervás J, Bobillo-Perez S, Carrasco JL, Pavon G, Balaguer-Gargallo M, Jordán I
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Fundació Sant Joan de Déu
Repository:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p29645
Online Access:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29645
Access Level:Open access
Keyword:critical care
lung ultrasound
paediatrics
pneumonia
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spelling Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.Guitart CBecerra-Hervás JBobillo-Perez SCarrasco JLPavon GBalaguer-Gargallo MJordán Icritical carelung ultrasoundpaediatricspneumoniaBackground: Pneumonia remains a major cause of morbidity and mortality among critically ill children. Lung ultrasound has emerged as a promising bedside diagnostic tool. Methods: A systematic review and meta-analysis across PubMed, Embase, The Cochrane Library, Scopus, World Health Organization Libraries, Epistemonikos, and MedRxiv was conducted to evaluate the diagnostic accuracy of lung ultrasound for pneumonia in paediatric patients. Publication bias was evaluated using the generalised Egger's test. Diagnostic performance metrics, including sensitivity, specificity, and the area under the receiver operating characteristic curve were pooled using a bivariate random-effects model. Results: Thirty studies comprising a total of 4356 children were included. The studies were of high methodological quality, with minimal heterogeneity. Lung ultrasound pooled sensitivity was 91% (95% CI: 87-94%), and specificity was 90% (95% CI: 83-94%). The ROC curve was 0.95 (95% CI: 0.90-0.95), indicating excellent diagnostic performance. Conclusions: LUS is a reliable and accurate imaging modality for diagnosing pneumonia in critically ill children. The findings support its use as a first-line diagnostic tool in emergency and intensive care settings. PROSPERO Research registration number: CRD42021223679.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29645DIAGNOSTICSISSN: 20754418reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p296452026-05-27T12:37:41Z
dc.title.none.fl_str_mv Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
title Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
spellingShingle Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
Guitart C
critical care
lung ultrasound
paediatrics
pneumonia
title_short Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
title_full Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
title_fullStr Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
title_full_unstemmed Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
title_sort Diagnostic Accuracy of Lung Ultrasound for Pneumonia in Acutely and Critically Ill Neonates, Children, and Young Adults: A Systematic Review and Meta-Analysis.
dc.creator.none.fl_str_mv Guitart C
Becerra-Hervás J
Bobillo-Perez S
Carrasco JL
Pavon G
Balaguer-Gargallo M
Jordán I
author Guitart C
author_facet Guitart C
Becerra-Hervás J
Bobillo-Perez S
Carrasco JL
Pavon G
Balaguer-Gargallo M
Jordán I
author_role author
author2 Becerra-Hervás J
Bobillo-Perez S
Carrasco JL
Pavon G
Balaguer-Gargallo M
Jordán I
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv critical care
lung ultrasound
paediatrics
pneumonia
topic critical care
lung ultrasound
paediatrics
pneumonia
description Background: Pneumonia remains a major cause of morbidity and mortality among critically ill children. Lung ultrasound has emerged as a promising bedside diagnostic tool. Methods: A systematic review and meta-analysis across PubMed, Embase, The Cochrane Library, Scopus, World Health Organization Libraries, Epistemonikos, and MedRxiv was conducted to evaluate the diagnostic accuracy of lung ultrasound for pneumonia in paediatric patients. Publication bias was evaluated using the generalised Egger's test. Diagnostic performance metrics, including sensitivity, specificity, and the area under the receiver operating characteristic curve were pooled using a bivariate random-effects model. Results: Thirty studies comprising a total of 4356 children were included. The studies were of high methodological quality, with minimal heterogeneity. Lung ultrasound pooled sensitivity was 91% (95% CI: 87-94%), and specificity was 90% (95% CI: 83-94%). The ROC curve was 0.95 (95% CI: 0.90-0.95), indicating excellent diagnostic performance. Conclusions: LUS is a reliable and accurate imaging modality for diagnosing pneumonia in critically ill children. The findings support its use as a first-line diagnostic tool in emergency and intensive care settings. PROSPERO Research registration number: CRD42021223679.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29645
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29645
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv DIAGNOSTICS
ISSN: 20754418
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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