Spinal facilitation of descending motor input

Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS,...

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Autores: Taccola, Giuliano, Kissane, Roger, Culaclii, Stanislav, Apicella, Rosamaria, Liu, Wentai, Gad, Parag|||0000-0001-8352-7614, Ichiyama, Ronaldo M., Chakrabarty, Samit, Edgerton, Victor|||0000-0001-6534-1875
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:294082
Acceso en línea:https://ddd.uab.cat/record/294082
https://dx.doi.org/urn:doi:10.1101/2023.06.30.547229
Access Level:acceso abierto
Palabra clave:Neuromodulation
Noisy waveforms
Spinal cord
Cord Dorsum Potentials
Muscle recruitment
Spinal reflex
Epidural neuroprosthesis
Multielectrode arrays
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spelling Spinal facilitation of descending motor inputTaccola, GiulianoKissane, RogerCulaclii, StanislavApicella, RosamariaLiu, WentaiGad, Parag|||0000-0001-8352-7614Ichiyama, Ronaldo M.Chakrabarty, SamitEdgerton, Victor|||0000-0001-6534-1875NeuromodulationNoisy waveformsSpinal cordCord Dorsum PotentialsMuscle recruitmentSpinal reflexEpidural neuroprosthesisMultielectrode arraysHighly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated by the acquisition of the classical multisite distribution of CDPs on the dorsal cord and their input-output profile elicited by pulses delivered to peripheral nerves. Apart from increased EMGs, DS selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked CDPs. Finally, DS increases excitability of post-synaptic spinal interneurons at the stimulation site and their responsiveness to any residual supraspinal control, thus supporting the use of electrical neuromodulation whenever the motor output is jeopardized by a weak volitional input, due to a partial disconnection from supraspinal structures and/or neuronal brain dysfunctions.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/294082https://dx.doi.org/urn:doi:10.1101/2023.06.30.547229reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 661452open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2940822026-06-06T12:50:31Z
dc.title.none.fl_str_mv Spinal facilitation of descending motor input
title Spinal facilitation of descending motor input
spellingShingle Spinal facilitation of descending motor input
Taccola, Giuliano
Neuromodulation
Noisy waveforms
Spinal cord
Cord Dorsum Potentials
Muscle recruitment
Spinal reflex
Epidural neuroprosthesis
Multielectrode arrays
title_short Spinal facilitation of descending motor input
title_full Spinal facilitation of descending motor input
title_fullStr Spinal facilitation of descending motor input
title_full_unstemmed Spinal facilitation of descending motor input
title_sort Spinal facilitation of descending motor input
dc.creator.none.fl_str_mv Taccola, Giuliano
Kissane, Roger
Culaclii, Stanislav
Apicella, Rosamaria
Liu, Wentai
Gad, Parag|||0000-0001-8352-7614
Ichiyama, Ronaldo M.
Chakrabarty, Samit
Edgerton, Victor|||0000-0001-6534-1875
author Taccola, Giuliano
author_facet Taccola, Giuliano
Kissane, Roger
Culaclii, Stanislav
Apicella, Rosamaria
Liu, Wentai
Gad, Parag|||0000-0001-8352-7614
Ichiyama, Ronaldo M.
Chakrabarty, Samit
Edgerton, Victor|||0000-0001-6534-1875
author_role author
author2 Kissane, Roger
Culaclii, Stanislav
Apicella, Rosamaria
Liu, Wentai
Gad, Parag|||0000-0001-8352-7614
Ichiyama, Ronaldo M.
Chakrabarty, Samit
Edgerton, Victor|||0000-0001-6534-1875
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Neuromodulation
Noisy waveforms
Spinal cord
Cord Dorsum Potentials
Muscle recruitment
Spinal reflex
Epidural neuroprosthesis
Multielectrode arrays
topic Neuromodulation
Noisy waveforms
Spinal cord
Cord Dorsum Potentials
Muscle recruitment
Spinal reflex
Epidural neuroprosthesis
Multielectrode arrays
description Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated by the acquisition of the classical multisite distribution of CDPs on the dorsal cord and their input-output profile elicited by pulses delivered to peripheral nerves. Apart from increased EMGs, DS selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked CDPs. Finally, DS increases excitability of post-synaptic spinal interneurons at the stimulation site and their responsiveness to any residual supraspinal control, thus supporting the use of electrical neuromodulation whenever the motor output is jeopardized by a weak volitional input, due to a partial disconnection from supraspinal structures and/or neuronal brain dysfunctions.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/294082
https://dx.doi.org/urn:doi:10.1101/2023.06.30.547229
url https://ddd.uab.cat/record/294082
https://dx.doi.org/urn:doi:10.1101/2023.06.30.547229
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 661452
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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