Large-scale evidence for the effect of the COL1A1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study

Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for l...

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Detalles Bibliográficos
Autores: Ralston, Stuart H., Uitterlinden, André G., Brandi, Maria Luisa, Balcells Comas, Susana, Langdahl, Bente L., Lips, Paul, Lorenc, Roman, Obermayer-Pietsch, Barbara, Scollen, Serena, Bustamante Pineda, Mariona, Bjerre Husted, Lise, Carey, Alisoun H., Díez Pérez, Adolfo, Dunning, Alison M., Falchetti, Alberto, Karczmarewicz, Elzbieta, Kruk, Marcin
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/43234
Acceso en línea:https://hdl.handle.net/2445/43234
Access Level:acceso abierto
Palabra clave:Osteoporosi
Genòmica
Densitometria òssia
Osteoporosis
Genomics
Bone densitometry
Descripción
Sumario:Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-large-scale studies of COLIA1 alleles in relation to these phenotypes.

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