Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain

Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before o...

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Autores: López, Yuly, Parra, Elena, Cepas, Virginio, Sanfeliu Sala, Isabel, Juncosa Morros, Maria Teresa, Andreu i Domingo, Antònia, Xercavins, Mariona, Pérez Jové, Josefa, Sanz, Sergi, Vergara Gómez, Andrea, Bosch Mestres, Jordi, Soto González, Sara M.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/204335
Acesso em linha:https://hdl.handle.net/2445/204335
Access Level:acceso abierto
Palavra-chave:Infeccions per estreptococs
Malalties neonatals
Streptococcal infections
Neonatal diseases
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spelling Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, SpainLópez, YulyParra, ElenaCepas, VirginioSanfeliu Sala, IsabelJuncosa Morros, Maria TeresaAndreu i Domingo, AntòniaXercavins, MarionaPérez Jové, JosefaSanz, SergiVergara Gómez, AndreaBosch Mestres, JordiSoto González, Sara M.Infeccions per estreptococsMalalties neonatalsStreptococcal infectionsNeonatal diseasesStreptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1–2% developing early neonatal infection if no preventive intervention is performed. The aim of this study was to characterize and compare serotypes, virulence factors and antimicrobial resistance of GBS isolates collected from pregnant women and newborns in several hospitals in Catalonia. Methods 242 GBS strains were analyzed including 95 colonizers and 68 pathogenic strains isolated from pregnant women, and 79 strains isolated from neonates with sepsis in order to determine serotype, virulence and antimicrobial resistance. Results Serotype distribution was different among the three groups, with serotypes Ia and II being significantly more frequent among colonizing strains (p = 0.001 and 0.012, respectively). Virulence factors bca and scpB were significantly more frequent among neonatal strains than pathogenic or colonizing strains (p = 0.0001 and 0.002, respectively). Pathogenic strains were significantly more resistant to erythromycin, clindamycin and azithromycin than their non-pathogenic counterparts. Conclusions Taking into account that neonatal sepsis represents a significant problem on a global scale, epidemiological surveillance, antimicrobial resistance and GBS virulence at the local level could provide important knowledge about these microorganisms as well as help to improve treatment and prevent invasive infection caused by this microorganism.Elsevier2023202320182023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion6 p.application/pdfhttps://hdl.handle.net/2445/204335Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.eimc.2017.08.006Enfermedades Infecciosas y Microbiologia Clinica, 2018, vol. 36, num.8, p. 472-477https://doi.org/10.1016/j.eimc.2017.08.006cc-by-nc-nd (c) Elsevier, 2018http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2043352026-05-29T05:05:01Z
dc.title.none.fl_str_mv Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
title Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
spellingShingle Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
López, Yuly
Infeccions per estreptococs
Malalties neonatals
Streptococcal infections
Neonatal diseases
title_short Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
title_full Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
title_fullStr Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
title_full_unstemmed Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
title_sort Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain
dc.creator.none.fl_str_mv López, Yuly
Parra, Elena
Cepas, Virginio
Sanfeliu Sala, Isabel
Juncosa Morros, Maria Teresa
Andreu i Domingo, Antònia
Xercavins, Mariona
Pérez Jové, Josefa
Sanz, Sergi
Vergara Gómez, Andrea
Bosch Mestres, Jordi
Soto González, Sara M.
author López, Yuly
author_facet López, Yuly
Parra, Elena
Cepas, Virginio
Sanfeliu Sala, Isabel
Juncosa Morros, Maria Teresa
Andreu i Domingo, Antònia
Xercavins, Mariona
Pérez Jové, Josefa
Sanz, Sergi
Vergara Gómez, Andrea
Bosch Mestres, Jordi
Soto González, Sara M.
author_role author
author2 Parra, Elena
Cepas, Virginio
Sanfeliu Sala, Isabel
Juncosa Morros, Maria Teresa
Andreu i Domingo, Antònia
Xercavins, Mariona
Pérez Jové, Josefa
Sanz, Sergi
Vergara Gómez, Andrea
Bosch Mestres, Jordi
Soto González, Sara M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infeccions per estreptococs
Malalties neonatals
Streptococcal infections
Neonatal diseases
topic Infeccions per estreptococs
Malalties neonatals
Streptococcal infections
Neonatal diseases
description Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1–2% developing early neonatal infection if no preventive intervention is performed. The aim of this study was to characterize and compare serotypes, virulence factors and antimicrobial resistance of GBS isolates collected from pregnant women and newborns in several hospitals in Catalonia. Methods 242 GBS strains were analyzed including 95 colonizers and 68 pathogenic strains isolated from pregnant women, and 79 strains isolated from neonates with sepsis in order to determine serotype, virulence and antimicrobial resistance. Results Serotype distribution was different among the three groups, with serotypes Ia and II being significantly more frequent among colonizing strains (p = 0.001 and 0.012, respectively). Virulence factors bca and scpB were significantly more frequent among neonatal strains than pathogenic or colonizing strains (p = 0.0001 and 0.002, respectively). Pathogenic strains were significantly more resistant to erythromycin, clindamycin and azithromycin than their non-pathogenic counterparts. Conclusions Taking into account that neonatal sepsis represents a significant problem on a global scale, epidemiological surveillance, antimicrobial resistance and GBS virulence at the local level could provide important knowledge about these microorganisms as well as help to improve treatment and prevent invasive infection caused by this microorganism.
publishDate 2018
dc.date.none.fl_str_mv 2018
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/204335
url https://hdl.handle.net/2445/204335
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.eimc.2017.08.006
Enfermedades Infecciosas y Microbiologia Clinica, 2018, vol. 36, num.8, p. 472-477
https://doi.org/10.1016/j.eimc.2017.08.006
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2018
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2018
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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