Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV

The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining...

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Detalhes bibliográficos
Autores: Notario Pérez, Fernando, Martín Illana, Araceli, Cazorla Luna, Raúl, Ruiz Caro, Roberto, Bedoya Del Olmo, Luis Miguel, Tamayo, Aitana, Rubio, Juan, Veiga Ochoa, María Dolores
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/19232
Acesso em linha:https://hdl.handle.net/20.500.14352/19232
Access Level:acceso abierto
Palavra-chave:Human Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
Chitosan
Mucoadhesive vaginal tablets
Tenofovir
Controlled release
Ex vivo bioadhesion
Swelling behaviour
Swelling witness microstructure
Enfermedades infecciosas
3205.05 Enfermedades Infecciosas
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oai_identifier_str oai:docta.ucm.es:20.500.14352/19232
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spelling Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIVNotario Pérez, FernandoMartín Illana, AraceliCazorla Luna, RaúlRuiz Caro, RobertoBedoya Del Olmo, Luis MiguelTamayo, AitanaRubio, JuanVeiga Ochoa, María DoloresHuman Immunodeficiency VirusAcquired Immunodeficiency SyndromeChitosanMucoadhesive vaginal tabletsTenofovirControlled releaseEx vivo bioadhesionSwelling behaviourSwelling witness microstructureEnfermedades infecciosas3205.05 Enfermedades InfecciosasThe main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit® RS. This paper assesses the potential of chitosan for the development of sustained-release vaginal tablets of Tenofovir and compares it with different polymers. The parameters assessed were the permanence time of the bioadhesion—determined ex vivo using bovine vaginal mucosa as substrate—the drug release profiles from the formulation to the medium (simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow the manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a sustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and may be useful for the prevention of sexual transmission of HIV.MDPIUniversidad Complutense de Madrid20172017-02-2120172017-02-21journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/19232reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/192322026-06-02T12:44:21Z
dc.title.none.fl_str_mv Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
title Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
spellingShingle Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
Notario Pérez, Fernando
Human Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
Chitosan
Mucoadhesive vaginal tablets
Tenofovir
Controlled release
Ex vivo bioadhesion
Swelling behaviour
Swelling witness microstructure
Enfermedades infecciosas
3205.05 Enfermedades Infecciosas
title_short Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
title_full Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
title_fullStr Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
title_full_unstemmed Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
title_sort Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV
dc.creator.none.fl_str_mv Notario Pérez, Fernando
Martín Illana, Araceli
Cazorla Luna, Raúl
Ruiz Caro, Roberto
Bedoya Del Olmo, Luis Miguel
Tamayo, Aitana
Rubio, Juan
Veiga Ochoa, María Dolores
author Notario Pérez, Fernando
author_facet Notario Pérez, Fernando
Martín Illana, Araceli
Cazorla Luna, Raúl
Ruiz Caro, Roberto
Bedoya Del Olmo, Luis Miguel
Tamayo, Aitana
Rubio, Juan
Veiga Ochoa, María Dolores
author_role author
author2 Martín Illana, Araceli
Cazorla Luna, Raúl
Ruiz Caro, Roberto
Bedoya Del Olmo, Luis Miguel
Tamayo, Aitana
Rubio, Juan
Veiga Ochoa, María Dolores
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Human Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
Chitosan
Mucoadhesive vaginal tablets
Tenofovir
Controlled release
Ex vivo bioadhesion
Swelling behaviour
Swelling witness microstructure
Enfermedades infecciosas
3205.05 Enfermedades Infecciosas
topic Human Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
Chitosan
Mucoadhesive vaginal tablets
Tenofovir
Controlled release
Ex vivo bioadhesion
Swelling behaviour
Swelling witness microstructure
Enfermedades infecciosas
3205.05 Enfermedades Infecciosas
description The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit® RS. This paper assesses the potential of chitosan for the development of sustained-release vaginal tablets of Tenofovir and compares it with different polymers. The parameters assessed were the permanence time of the bioadhesion—determined ex vivo using bovine vaginal mucosa as substrate—the drug release profiles from the formulation to the medium (simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow the manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a sustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and may be useful for the prevention of sexual transmission of HIV.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-02-21
2017
2017-02-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/19232
url https://hdl.handle.net/20.500.14352/19232
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415968318423040
score 15,301603

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