In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma

Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the tumoral epigenome is characterized by both specific and general shifts in the DNA methylation and histone-modification landscapes.1 However, in co...

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Autores: Pérez Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, San Sebastian, Eider, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Moutinho, Cátia, Setién, Fernando, Villanueva Garatachea, Alberto, González Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A., Cossio, Fernando P., Esteller, Manel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/133681
Acesso em linha:https://hdl.handle.net/2445/133681
Access Level:Acceso aberto
Palavra-chave:Inhibidors enzimàtics
Histones
Cèl·lules T
Limfomes
Epigenètica
Enzyme inhibitors
T cells
Lymphomas
Epigenetics
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spelling In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphomaPérez Salvia, MontserratAldaba, EnekoVara, YosuFabre, MyriamFerrer, CristinaMasdeu, CarmeZubia, AizpeaSan Sebastian, EiderOtaegui, DorletaLlinàs-Arias, PereRosselló-Tortella, MargalidaBerdasco, MaríaMoutinho, CátiaSetién, FernandoVillanueva Garatachea, AlbertoGonzález Barca, EvaMuncunill, JosepNavarro, José-TomásPiris, Miguel A.Cossio, Fernando P.Esteller, ManelInhibidors enzimàticsHistonesCèl·lules TLimfomesEpigenèticaEnzyme inhibitorsHistonesT cellsLymphomasEpigeneticsCancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the tumoral epigenome is characterized by both specific and general shifts in the DNA methylation and histone-modification landscapes.1 However, in contrast to genetic disruption, the effect of epigenetic modifications or marks may potentially be reversed by the use of drugs that target enzymes involved in adding, removing or signaling DNA methylation and histone modifications.1 This basic knowledge has been adopted into clinical practice, and inhibitors of histone deacetylases and DNA demethylating agents have been approved for use in the therapy of hematologic malignancies, such as cutaneous T-cell lymphoma and myelodysplastic syndrome, respectively.2 Other promising epigenetic drugs include inhibitors of histone methyltransferases,2 histone demethylases,2 histone kinases,3 and bromodomain proteins that interfere with the 'reading' of acetylated histone residues.Ferrata Storti Foundation2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/133681Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3324/haematol.2018.189241Haematologica, 2018, vol. 103, num. 11, p. e537-e540https://doi.org/10.3324/haematol.2018.189241(c) Ferrata Storti Foundation, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1336812026-05-29T05:05:01Z
dc.title.none.fl_str_mv In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
title In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
spellingShingle In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
Pérez Salvia, Montserrat
Inhibidors enzimàtics
Histones
Cèl·lules T
Limfomes
Epigenètica
Enzyme inhibitors
Histones
T cells
Lymphomas
Epigenetics
title_short In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
title_full In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
title_fullStr In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
title_full_unstemmed In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
title_sort In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
dc.creator.none.fl_str_mv Pérez Salvia, Montserrat
Aldaba, Eneko
Vara, Yosu
Fabre, Myriam
Ferrer, Cristina
Masdeu, Carme
Zubia, Aizpea
San Sebastian, Eider
Otaegui, Dorleta
Llinàs-Arias, Pere
Rosselló-Tortella, Margalida
Berdasco, María
Moutinho, Cátia
Setién, Fernando
Villanueva Garatachea, Alberto
González Barca, Eva
Muncunill, Josep
Navarro, José-Tomás
Piris, Miguel A.
Cossio, Fernando P.
Esteller, Manel
author Pérez Salvia, Montserrat
author_facet Pérez Salvia, Montserrat
Aldaba, Eneko
Vara, Yosu
Fabre, Myriam
Ferrer, Cristina
Masdeu, Carme
Zubia, Aizpea
San Sebastian, Eider
Otaegui, Dorleta
Llinàs-Arias, Pere
Rosselló-Tortella, Margalida
Berdasco, María
Moutinho, Cátia
Setién, Fernando
Villanueva Garatachea, Alberto
González Barca, Eva
Muncunill, Josep
Navarro, José-Tomás
Piris, Miguel A.
Cossio, Fernando P.
Esteller, Manel
author_role author
author2 Aldaba, Eneko
Vara, Yosu
Fabre, Myriam
Ferrer, Cristina
Masdeu, Carme
Zubia, Aizpea
San Sebastian, Eider
Otaegui, Dorleta
Llinàs-Arias, Pere
Rosselló-Tortella, Margalida
Berdasco, María
Moutinho, Cátia
Setién, Fernando
Villanueva Garatachea, Alberto
González Barca, Eva
Muncunill, Josep
Navarro, José-Tomás
Piris, Miguel A.
Cossio, Fernando P.
Esteller, Manel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Inhibidors enzimàtics
Histones
Cèl·lules T
Limfomes
Epigenètica
Enzyme inhibitors
Histones
T cells
Lymphomas
Epigenetics
topic Inhibidors enzimàtics
Histones
Cèl·lules T
Limfomes
Epigenètica
Enzyme inhibitors
Histones
T cells
Lymphomas
Epigenetics
description Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the tumoral epigenome is characterized by both specific and general shifts in the DNA methylation and histone-modification landscapes.1 However, in contrast to genetic disruption, the effect of epigenetic modifications or marks may potentially be reversed by the use of drugs that target enzymes involved in adding, removing or signaling DNA methylation and histone modifications.1 This basic knowledge has been adopted into clinical practice, and inhibitors of histone deacetylases and DNA demethylating agents have been approved for use in the therapy of hematologic malignancies, such as cutaneous T-cell lymphoma and myelodysplastic syndrome, respectively.2 Other promising epigenetic drugs include inhibitors of histone methyltransferases,2 histone demethylases,2 histone kinases,3 and bromodomain proteins that interfere with the 'reading' of acetylated histone residues.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/133681
url https://hdl.handle.net/2445/133681
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3324/haematol.2018.189241
Haematologica, 2018, vol. 103, num. 11, p. e537-e540
https://doi.org/10.3324/haematol.2018.189241
dc.rights.none.fl_str_mv (c) Ferrata Storti Foundation, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Ferrata Storti Foundation, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1 p.
application/pdf
dc.publisher.none.fl_str_mv Ferrata Storti Foundation
publisher.none.fl_str_mv Ferrata Storti Foundation
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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