Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo

Plasma-treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show that the oxidative stress delivered by such hydrogels does not adversely affect...

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Autores: Solé Martí, Xavier|||0000-0002-5544-2485, Labay, Cédric Pierre|||0000-0001-5147-5100, Raymond Llorens, Yago, Franch, Jordi, Benítez Iglesias, Raúl|||0000-0002-8782-9406, Ginebra Molins, Maria Pau|||0000-0002-4700-5621, Canal Barnils, Cristina|||0000-0002-3039-7462
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/384289
Acceso en línea:https://hdl.handle.net/2117/384289
https://dx.doi.org/10.1002/ppap.202200155
Access Level:acceso abierto
Palabra clave:Tissue engineering
Bone graft
Ceramic-hydrogel composite
Cold atmospheric plasma
Local therapy
Plasma- treated polymer solutions
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria biomèdica
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spelling Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivoSolé Martí, Xavier|||0000-0002-5544-2485Labay, Cédric Pierre|||0000-0001-5147-5100Raymond Llorens, YagoFranch, JordiBenítez Iglesias, Raúl|||0000-0002-8782-9406Ginebra Molins, Maria Pau|||0000-0002-4700-5621Canal Barnils, Cristina|||0000-0002-3039-7462Tissue engineeringBone graftCeramic-hydrogel compositeCold atmospheric plasmaLocal therapyPlasma- treated polymer solutionsEnginyeria de teixitsÀrees temàtiques de la UPC::Enginyeria biomèdicaPlasma-treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show that the oxidative stress delivered by such hydrogels does not adversely affect healthy tissues. This is evaluated here by investigating the in vivo performance of a robocasted calcium phosphate cement infiltrated by a plasma-treated hydrogel. The plasma-treated composite implanted in a critical size bone defect of healthy rabbits revealed its safety, allowing equivalent bone ingrowth compared to the control scaffolds and to that of direct plasma treatment of the bone defect. This opens the door for using composite biomaterials containing plasma-generated reactive species in bone therapies.Peer ReviewedWiley (John Wiley & Sons)20222022-01-0120232023-02-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/384289https://dx.doi.org/10.1002/ppap.202200155reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3842892026-05-27T15:37:01Z
dc.title.none.fl_str_mv Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
title Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
spellingShingle Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
Solé Martí, Xavier|||0000-0002-5544-2485
Tissue engineering
Bone graft
Ceramic-hydrogel composite
Cold atmospheric plasma
Local therapy
Plasma- treated polymer solutions
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria biomèdica
title_short Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
title_full Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
title_fullStr Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
title_full_unstemmed Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
title_sort Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
dc.creator.none.fl_str_mv Solé Martí, Xavier|||0000-0002-5544-2485
Labay, Cédric Pierre|||0000-0001-5147-5100
Raymond Llorens, Yago
Franch, Jordi
Benítez Iglesias, Raúl|||0000-0002-8782-9406
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Canal Barnils, Cristina|||0000-0002-3039-7462
author Solé Martí, Xavier|||0000-0002-5544-2485
author_facet Solé Martí, Xavier|||0000-0002-5544-2485
Labay, Cédric Pierre|||0000-0001-5147-5100
Raymond Llorens, Yago
Franch, Jordi
Benítez Iglesias, Raúl|||0000-0002-8782-9406
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Canal Barnils, Cristina|||0000-0002-3039-7462
author_role author
author2 Labay, Cédric Pierre|||0000-0001-5147-5100
Raymond Llorens, Yago
Franch, Jordi
Benítez Iglesias, Raúl|||0000-0002-8782-9406
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Canal Barnils, Cristina|||0000-0002-3039-7462
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Tissue engineering
Bone graft
Ceramic-hydrogel composite
Cold atmospheric plasma
Local therapy
Plasma- treated polymer solutions
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria biomèdica
topic Tissue engineering
Bone graft
Ceramic-hydrogel composite
Cold atmospheric plasma
Local therapy
Plasma- treated polymer solutions
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria biomèdica
description Plasma-treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show that the oxidative stress delivered by such hydrogels does not adversely affect healthy tissues. This is evaluated here by investigating the in vivo performance of a robocasted calcium phosphate cement infiltrated by a plasma-treated hydrogel. The plasma-treated composite implanted in a critical size bone defect of healthy rabbits revealed its safety, allowing equivalent bone ingrowth compared to the control scaffolds and to that of direct plasma treatment of the bone defect. This opens the door for using composite biomaterials containing plasma-generated reactive species in bone therapies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2023
2023-02-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/384289
https://dx.doi.org/10.1002/ppap.202200155
url https://hdl.handle.net/2117/384289
https://dx.doi.org/10.1002/ppap.202200155
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley (John Wiley & Sons)
publisher.none.fl_str_mv Wiley (John Wiley & Sons)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415963261140992
score 15,301603

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