Hepatitis G virus infection in chronic liver disease

Background¿The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims¿To evaluate the prevalence and meaning of HGV infection in a large series of patients wit...

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Autores: Guilera Sardà, Magda, Sáiz Calahorra, Juan Carlos, López Labrador, Francesc Xavier, Olmedo Casas, Eva, Ampurdanés, Sergi, Forns, Xavier, Bruix Tudó, Jordi, Parés Darnaculleta, Albert, Sánchez Tapias, José M. (José María), Jiménez de Anta Losada, María Teresa, Rodés, J.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:1998
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/18664
Acesso em linha:https://hdl.handle.net/2445/18664
Access Level:acceso abierto
Palavra-chave:GB virus C
Hepatitis vírica
Malalties cròniques
GB virus C (GBV-C)
Viral hepatitis
Chronic diseases
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spelling Hepatitis G virus infection in chronic liver diseaseGuilera Sardà, MagdaSáiz Calahorra, Juan CarlosLópez Labrador, Francesc XavierOlmedo Casas, EvaAmpurdanés, SergiForns, XavierBruix Tudó, JordiParés Darnaculleta, AlbertSánchez Tapias, José M. (José María)Jiménez de Anta Losada, María TeresaRodés, J.GB virus CHepatitis víricaMalalties cròniquesGB virus C (GBV-C)Viral hepatitisChronic diseasesBackground¿The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims¿To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects¿Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods¿HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5¿ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results¿The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions¿The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.BMJ Group1998info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/18664Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.42.1.107Gut, 1998, vol. 42, núm. 1, p. 107-111http://dx.doi.org/10.1136/gut.42.1.107(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/186642026-05-27T06:46:51Z
dc.title.none.fl_str_mv Hepatitis G virus infection in chronic liver disease
title Hepatitis G virus infection in chronic liver disease
spellingShingle Hepatitis G virus infection in chronic liver disease
Guilera Sardà, Magda
GB virus C
Hepatitis vírica
Malalties cròniques
GB virus C (GBV-C)
Viral hepatitis
Chronic diseases
title_short Hepatitis G virus infection in chronic liver disease
title_full Hepatitis G virus infection in chronic liver disease
title_fullStr Hepatitis G virus infection in chronic liver disease
title_full_unstemmed Hepatitis G virus infection in chronic liver disease
title_sort Hepatitis G virus infection in chronic liver disease
dc.creator.none.fl_str_mv Guilera Sardà, Magda
Sáiz Calahorra, Juan Carlos
López Labrador, Francesc Xavier
Olmedo Casas, Eva
Ampurdanés, Sergi
Forns, Xavier
Bruix Tudó, Jordi
Parés Darnaculleta, Albert
Sánchez Tapias, José M. (José María)
Jiménez de Anta Losada, María Teresa
Rodés, J.
author Guilera Sardà, Magda
author_facet Guilera Sardà, Magda
Sáiz Calahorra, Juan Carlos
López Labrador, Francesc Xavier
Olmedo Casas, Eva
Ampurdanés, Sergi
Forns, Xavier
Bruix Tudó, Jordi
Parés Darnaculleta, Albert
Sánchez Tapias, José M. (José María)
Jiménez de Anta Losada, María Teresa
Rodés, J.
author_role author
author2 Sáiz Calahorra, Juan Carlos
López Labrador, Francesc Xavier
Olmedo Casas, Eva
Ampurdanés, Sergi
Forns, Xavier
Bruix Tudó, Jordi
Parés Darnaculleta, Albert
Sánchez Tapias, José M. (José María)
Jiménez de Anta Losada, María Teresa
Rodés, J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GB virus C
Hepatitis vírica
Malalties cròniques
GB virus C (GBV-C)
Viral hepatitis
Chronic diseases
topic GB virus C
Hepatitis vírica
Malalties cròniques
GB virus C (GBV-C)
Viral hepatitis
Chronic diseases
description Background¿The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims¿To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects¿Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods¿HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5¿ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results¿The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions¿The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.
publishDate 1998
dc.date.none.fl_str_mv 1998
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/18664
url https://hdl.handle.net/2445/18664
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.42.1.107
Gut, 1998, vol. 42, núm. 1, p. 107-111
http://dx.doi.org/10.1136/gut.42.1.107
dc.rights.none.fl_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Group
publisher.none.fl_str_mv BMJ Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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