Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

One of the most common types of fibrotic liver occurs in patients with non-alcoholic fatty liver disease (NAFLD), which may develop into non-alcoholic steatohepatitis (NASH). Hepatic stellate cells (HSCs) are the primary fibrogenic cell type activated following liver injury, moving from a quiescent...

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Detalles Bibliográficos
Autores: Fernández Fondevila, Marcos, Fernández, Uxía, Heras Domínguez, Violeta, Parracho Martínez, Tamara, González Rellán, María Jesús, Nóvoa Deaño, Eva María, Porteiro Couto, Begoña, Alonso, Cristina, Mayo, Rebeca, Silva Lima, Natália da, Iglesias García, Cristina, Filliol, Aveline, Senra Viñas, Ana, Delgado, Teresa, Woodhoo, Ashwin, Herrero, Laura, Serra, Dolors, Prevot, Vincent, Schwaninger, Markus, López Pérez, Miguel A., Diéguez González, Carlos, Millet, Óscar, Mato de la Paz, José María, Cubero Palero, Francisco Javier, Varela Rey, Marta María, Iruzubieta, Paula, Crespo, Javier, Martínez Chantar, María Luz, Schwabe, Robert F., Nogueiras Pozo, Rubén
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/28817
Acceso en línea:http://hdl.handle.net/10347/28817
Access Level:acceso abierto
Descripción
Sumario:One of the most common types of fibrotic liver occurs in patients with non-alcoholic fatty liver disease (NAFLD), which may develop into non-alcoholic steatohepatitis (NASH). Hepatic stellate cells (HSCs) are the primary fibrogenic cell type activated following liver injury, moving from a quiescent phenotype rich in vitamin A into activated myofibroblast-like cells with proliferative and migratory properties.