Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT

Persimmon (Diospyros kaki Thunb.) fruits are a remarkable source of carotenoids, which have shown protective effects against UV radiation in bacteria, fungi, algae, and plants. The aim of this study was to analyze the photoprotection provided by an acetone extract, rich in carotenoids and obtained f...

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Autores: Gea Botella, Sara, Moreno, Bryan, De La Casa Domingo, Laura, Salazar, Julio, Martí, Nuria, MARTÍNEZ-MADRID, MARIA CONCEPCIÓN, Valero Roche, Manuel, Saura, Domingo
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/35896
Acceso en línea:https://hdl.handle.net/11000/35896
Access Level:acceso abierto
Palabra clave:Diospyros kaki
UV radiation
Photoprotection
Reactive oxygen species
Antimicrobial activity
Skin-care cosmetics
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spelling Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaTGea Botella, SaraMoreno, BryanDe La Casa Domingo, LauraSalazar, JulioMartí, NuriaMARTÍNEZ-MADRID, MARIA CONCEPCIÓNValero Roche, ManuelSaura, DomingoDiospyros kakiUV radiationPhotoprotectionReactive oxygen speciesAntimicrobial activitySkin-care cosmeticsPersimmon (Diospyros kaki Thunb.) fruits are a remarkable source of carotenoids, which have shown protective effects against UV radiation in bacteria, fungi, algae, and plants. The aim of this study was to analyze the photoprotection provided by an acetone extract, rich in carotenoids and obtained from byproducts derived from the persimmon juice industry, against UV-induced cell death in the keratinocyte HaCaT cell line. For this purpose, the cytotoxicity and phototoxicity of carotenoid extract, as well as its intracellular reactive oxygen species (ROS) scavenging and anti-adhesive activities towards HaCaT cells, were evaluated. The in vitro permeation test provided information about the permeability of the carotenoid extract. Persimmon extracts, rich in carotenoids (PEC), were absorbed by HaCaT keratinocyte cells, which reduced the UV-induced intracellular ROS production in treated cells. Thus, PEC exerted a photoprotective and regenerative effect on UV-irradiated HaCaT cells, and this protection was UV dose-dependent. No cytotoxic effect was observed in HaCaT cultures at the concentration tested. PEC treatment also stimulated the adhesion capacity of skin microbiome to HaCaT cells, while exhibiting a significant anti-adhesive activity against all tested pathogens. In conclusion, PEC showed potential for use as a functional ingredient in skin-care productsMDPIDepartamentos de la UMH::Agroquímica y Medio Ambiente202520252021info:eu-repo/semantics/articleapplication/pdf16application/pdfhttps://hdl.handle.net/11000/35896reponame:REDIUMH. Depósito Digital de la UMHinstname:Universitat Politècnica de València (UPV)Ingléshttps://doi.org/10.3390/pharmaceutics13111898info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/358962026-05-27T13:36:21Z
dc.title.none.fl_str_mv Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
title Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
spellingShingle Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
Gea Botella, Sara
Diospyros kaki
UV radiation
Photoprotection
Reactive oxygen species
Antimicrobial activity
Skin-care cosmetics
title_short Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
title_full Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
title_fullStr Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
title_full_unstemmed Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
title_sort Carotenoids from Persimmon (Diospyros kaki Thunb.) Byproducts Exert Photoprotective, Antioxidative and Microbial Anti-Adhesive Effects on HaCaT
dc.creator.none.fl_str_mv Gea Botella, Sara
Moreno, Bryan
De La Casa Domingo, Laura
Salazar, Julio
Martí, Nuria
MARTÍNEZ-MADRID, MARIA CONCEPCIÓN
Valero Roche, Manuel
Saura, Domingo
author Gea Botella, Sara
author_facet Gea Botella, Sara
Moreno, Bryan
De La Casa Domingo, Laura
Salazar, Julio
Martí, Nuria
MARTÍNEZ-MADRID, MARIA CONCEPCIÓN
Valero Roche, Manuel
Saura, Domingo
author_role author
author2 Moreno, Bryan
De La Casa Domingo, Laura
Salazar, Julio
Martí, Nuria
MARTÍNEZ-MADRID, MARIA CONCEPCIÓN
Valero Roche, Manuel
Saura, Domingo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Agroquímica y Medio Ambiente
dc.subject.none.fl_str_mv Diospyros kaki
UV radiation
Photoprotection
Reactive oxygen species
Antimicrobial activity
Skin-care cosmetics
topic Diospyros kaki
UV radiation
Photoprotection
Reactive oxygen species
Antimicrobial activity
Skin-care cosmetics
description Persimmon (Diospyros kaki Thunb.) fruits are a remarkable source of carotenoids, which have shown protective effects against UV radiation in bacteria, fungi, algae, and plants. The aim of this study was to analyze the photoprotection provided by an acetone extract, rich in carotenoids and obtained from byproducts derived from the persimmon juice industry, against UV-induced cell death in the keratinocyte HaCaT cell line. For this purpose, the cytotoxicity and phototoxicity of carotenoid extract, as well as its intracellular reactive oxygen species (ROS) scavenging and anti-adhesive activities towards HaCaT cells, were evaluated. The in vitro permeation test provided information about the permeability of the carotenoid extract. Persimmon extracts, rich in carotenoids (PEC), were absorbed by HaCaT keratinocyte cells, which reduced the UV-induced intracellular ROS production in treated cells. Thus, PEC exerted a photoprotective and regenerative effect on UV-irradiated HaCaT cells, and this protection was UV dose-dependent. No cytotoxic effect was observed in HaCaT cultures at the concentration tested. PEC treatment also stimulated the adhesion capacity of skin microbiome to HaCaT cells, while exhibiting a significant anti-adhesive activity against all tested pathogens. In conclusion, PEC showed potential for use as a functional ingredient in skin-care products
publishDate 2021
dc.date.none.fl_str_mv 2021
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/35896
url https://hdl.handle.net/11000/35896
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/pharmaceutics13111898
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
16
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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