Is plasma cardiotrophin-1 a marker of hypertensive heart disease?
OBJECTIVE: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2005 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/19914 |
| Acceso en línea: | https://hdl.handle.net/10171/19914 |
| Access Level: | acceso abierto |
| Palabra clave: | Cardiotrophin-1 Hypertensive heart disease Left ventricular |
| id |
ES_a8a8bb0ac9670f81335d00ed562bfcee |
|---|---|
| oai_identifier_str |
oai:dadun.unav.edu:10171/19914 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease?Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0cSarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160Borras-Cuesta, F. (Francisco)|||/items/9f3719bd-4cf6-4e5b-b672-39179b54e8ccDíaz-Dorronsoro, I. (Inés)|||/items/eb812d3a-1796-4950-b894-c77b1b522c41Barba, J. (Joaquín)|||/items/7ba5bad3-fc2c-4be1-9498-95083555fc81Tomas, L. (Lourdes)|||/items/cd279eb6-fd63-4615-8676-8ab4cfea0747Lozano, E. (Elisa)|||/items/bf101e02-aadc-4ab0-8d02-d55a63a23be9Serrano, M. (Manuel)|||/items/f8a0b6a3-32b3-46e5-baaa-dfd3eb1f92c9Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001fBeloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420dFortuño-Cebamanos, M.A. (María Antonia)|||/items/4dc78327-206a-4160-a352-90965670b0ecDiez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41Cardiotrophin-1Hypertensive heart diseaseLeft ventricularOBJECTIVE: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH). METHODS: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1. RESULTS: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09). CONCLUSIONS: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease.Lippincott, Williams & WilkinsDadun. Depósito Académico Digital Universidad de Navarra20112011-11-2320052005-01-0120052005-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/19914reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/199142026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| title |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| spellingShingle |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0 Cardiotrophin-1 Hypertensive heart disease Left ventricular |
| title_short |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| title_full |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| title_fullStr |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| title_full_unstemmed |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| title_sort |
Is plasma cardiotrophin-1 a marker of hypertensive heart disease? |
| dc.creator.none.fl_str_mv |
Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0 Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515 Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c Sarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160 Borras-Cuesta, F. (Francisco)|||/items/9f3719bd-4cf6-4e5b-b672-39179b54e8cc Díaz-Dorronsoro, I. (Inés)|||/items/eb812d3a-1796-4950-b894-c77b1b522c41 Barba, J. (Joaquín)|||/items/7ba5bad3-fc2c-4be1-9498-95083555fc81 Tomas, L. (Lourdes)|||/items/cd279eb6-fd63-4615-8676-8ab4cfea0747 Lozano, E. (Elisa)|||/items/bf101e02-aadc-4ab0-8d02-d55a63a23be9 Serrano, M. (Manuel)|||/items/f8a0b6a3-32b3-46e5-baaa-dfd3eb1f92c9 Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d Fortuño-Cebamanos, M.A. (María Antonia)|||/items/4dc78327-206a-4160-a352-90965670b0ec Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41 |
| author |
Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0 |
| author_facet |
Lopez-Salazar, M.B. (María Begoña)|||/items/153e0e37-14b0-403e-afab-8af00c4edde0 Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515 Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c Sarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160 Borras-Cuesta, F. (Francisco)|||/items/9f3719bd-4cf6-4e5b-b672-39179b54e8cc Díaz-Dorronsoro, I. (Inés)|||/items/eb812d3a-1796-4950-b894-c77b1b522c41 Barba, J. (Joaquín)|||/items/7ba5bad3-fc2c-4be1-9498-95083555fc81 Tomas, L. (Lourdes)|||/items/cd279eb6-fd63-4615-8676-8ab4cfea0747 Lozano, E. (Elisa)|||/items/bf101e02-aadc-4ab0-8d02-d55a63a23be9 Serrano, M. (Manuel)|||/items/f8a0b6a3-32b3-46e5-baaa-dfd3eb1f92c9 Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d Fortuño-Cebamanos, M.A. (María Antonia)|||/items/4dc78327-206a-4160-a352-90965670b0ec Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41 |
| author_role |
author |
| author2 |
Gonzalez, A. (Arantxa)|||/items/9c64c0f4-66b4-4b51-8593-0e50c091a515 Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c Sarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160 Borras-Cuesta, F. (Francisco)|||/items/9f3719bd-4cf6-4e5b-b672-39179b54e8cc Díaz-Dorronsoro, I. (Inés)|||/items/eb812d3a-1796-4950-b894-c77b1b522c41 Barba, J. (Joaquín)|||/items/7ba5bad3-fc2c-4be1-9498-95083555fc81 Tomas, L. (Lourdes)|||/items/cd279eb6-fd63-4615-8676-8ab4cfea0747 Lozano, E. (Elisa)|||/items/bf101e02-aadc-4ab0-8d02-d55a63a23be9 Serrano, M. (Manuel)|||/items/f8a0b6a3-32b3-46e5-baaa-dfd3eb1f92c9 Varo-Cenarruzabeitia, N. (Nerea)|||/items/18b5a757-44b9-4e23-8a8c-ad907969001f Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d Fortuño-Cebamanos, M.A. (María Antonia)|||/items/4dc78327-206a-4160-a352-90965670b0ec Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41 |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Cardiotrophin-1 Hypertensive heart disease Left ventricular |
| topic |
Cardiotrophin-1 Hypertensive heart disease Left ventricular |
| description |
OBJECTIVE: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH). METHODS: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1. RESULTS: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09). CONCLUSIONS: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005 2005-01-01 2005 2005-01-01 2011 2011-11-23 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/19914 |
| url |
https://hdl.handle.net/10171/19914 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
| publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869415916794544128 |
| score |
15,300724 |