Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:236585 |
| Acceso en línea: | https://ddd.uab.cat/record/236585 https://dx.doi.org/urn:doi:10.1007/s00429-020-02125-3 |
| Access Level: | acceso abierto |
| Palabra clave: | APOE-ε4 BDNF Hippocampal subfields Imaging genetics Subiculum Val66Met |
| id |
ES_a8a0eb9d69e04dfbcb99bce68a4921e6 |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:236585 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA studyVilor Tejedor, NataliaOperto, GregoryEvans, T. E.Falcon, CarlesCrous-Bou, Marta|||0000-0003-1493-4288Minguillón, CarolinaCacciaglia, RaffaeleMilà-Alomà, MartaGrau-Rivera, Oriol|||0000-0002-4730-5341Suárez-Calvet, Marc|||0000-0002-2993-569XGarrido-Martín, DiegoMoran, S.|||0000-0003-4192-8983Esteller, M.|||0000-0003-4490-6093Adams, Hieab H. H.|||0000-0003-3687-2508Molinuevo, José Luis|||0000-0003-0485-6001Guigó, Roderic|||0000-0002-5738-4477Gispert, Juan Domingo|||0000-0002-6155-0642APOE-ε4BDNFHippocampal subfieldsImaging geneticsSubiculumVal66MetBackground: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. However, it remains to be elucidated whether there is an impact of BDNF Val66Met polymorphism on the volumes of the hippocampal subfield volumes (HSv) in cognitively unimpaired (CU) individuals, and the interactive effect with the APOE-ε4 status. Methods: BDNF Val66Met and APOE genotypes were determined in a sample of 430 CU late/middle-aged participants from the ALFA study (ALzheimer and FAmilies). Participants underwent a brain 3D-T1-weighted MRI scan, and volumes of the HSv were determined using Freesurfer (v6.0). The effects of the BDNF Val66Met genotype on the HSv were assessed using general linear models corrected by age, gender, education, number of APOE-ε4 alleles and total intracranial volume. We also investigated whether the association between APOE-ε4 allele and HSv were modified by BDNF Val66Met genotypes. Results: BDNF Val66Met carriers showed larger bilateral volumes of the subiculum subfield. In addition, HSv reductions associated with APOE-ε4 allele were significantly moderated by BDNF Val66Met status. BDNF Met carriers who were also APOE-ε4 homozygous showed patterns of higher HSv than BDNF Val carriers. Conclusion: To our knowledge, the present study is the first to show that carrying the BDNF Val66Met polymorphisms partially compensates the decreased on HSv associated with APOE-ε4 in middle-age cognitively unimpaired individuals.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236585https://dx.doi.org/urn:doi:10.1007/s00429-020-02125-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2018-038085-IAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 SLT002-16-00201Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 IEDI-2016-00690European Commission https://doi.org/10.13039/501100000780 752310open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2365852026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| title |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| spellingShingle |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study Vilor Tejedor, Natalia APOE-ε4 BDNF Hippocampal subfields Imaging genetics Subiculum Val66Met |
| title_short |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| title_full |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| title_fullStr |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| title_full_unstemmed |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| title_sort |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study |
| dc.creator.none.fl_str_mv |
Vilor Tejedor, Natalia Operto, Gregory Evans, T. E. Falcon, Carles Crous-Bou, Marta|||0000-0003-1493-4288 Minguillón, Carolina Cacciaglia, Raffaele Milà-Alomà, Marta Grau-Rivera, Oriol|||0000-0002-4730-5341 Suárez-Calvet, Marc|||0000-0002-2993-569X Garrido-Martín, Diego Moran, S.|||0000-0003-4192-8983 Esteller, M.|||0000-0003-4490-6093 Adams, Hieab H. H.|||0000-0003-3687-2508 Molinuevo, José Luis|||0000-0003-0485-6001 Guigó, Roderic|||0000-0002-5738-4477 Gispert, Juan Domingo|||0000-0002-6155-0642 |
| author |
Vilor Tejedor, Natalia |
| author_facet |
Vilor Tejedor, Natalia Operto, Gregory Evans, T. E. Falcon, Carles Crous-Bou, Marta|||0000-0003-1493-4288 Minguillón, Carolina Cacciaglia, Raffaele Milà-Alomà, Marta Grau-Rivera, Oriol|||0000-0002-4730-5341 Suárez-Calvet, Marc|||0000-0002-2993-569X Garrido-Martín, Diego Moran, S.|||0000-0003-4192-8983 Esteller, M.|||0000-0003-4490-6093 Adams, Hieab H. H.|||0000-0003-3687-2508 Molinuevo, José Luis|||0000-0003-0485-6001 Guigó, Roderic|||0000-0002-5738-4477 Gispert, Juan Domingo|||0000-0002-6155-0642 |
| author_role |
author |
| author2 |
Operto, Gregory Evans, T. E. Falcon, Carles Crous-Bou, Marta|||0000-0003-1493-4288 Minguillón, Carolina Cacciaglia, Raffaele Milà-Alomà, Marta Grau-Rivera, Oriol|||0000-0002-4730-5341 Suárez-Calvet, Marc|||0000-0002-2993-569X Garrido-Martín, Diego Moran, S.|||0000-0003-4192-8983 Esteller, M.|||0000-0003-4490-6093 Adams, Hieab H. H.|||0000-0003-3687-2508 Molinuevo, José Luis|||0000-0003-0485-6001 Guigó, Roderic|||0000-0002-5738-4477 Gispert, Juan Domingo|||0000-0002-6155-0642 |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
APOE-ε4 BDNF Hippocampal subfields Imaging genetics Subiculum Val66Met |
| topic |
APOE-ε4 BDNF Hippocampal subfields Imaging genetics Subiculum Val66Met |
| description |
Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. However, it remains to be elucidated whether there is an impact of BDNF Val66Met polymorphism on the volumes of the hippocampal subfield volumes (HSv) in cognitively unimpaired (CU) individuals, and the interactive effect with the APOE-ε4 status. Methods: BDNF Val66Met and APOE genotypes were determined in a sample of 430 CU late/middle-aged participants from the ALFA study (ALzheimer and FAmilies). Participants underwent a brain 3D-T1-weighted MRI scan, and volumes of the HSv were determined using Freesurfer (v6.0). The effects of the BDNF Val66Met genotype on the HSv were assessed using general linear models corrected by age, gender, education, number of APOE-ε4 alleles and total intracranial volume. We also investigated whether the association between APOE-ε4 allele and HSv were modified by BDNF Val66Met genotypes. Results: BDNF Val66Met carriers showed larger bilateral volumes of the subiculum subfield. In addition, HSv reductions associated with APOE-ε4 allele were significantly moderated by BDNF Val66Met status. BDNF Met carriers who were also APOE-ε4 homozygous showed patterns of higher HSv than BDNF Val carriers. Conclusion: To our knowledge, the present study is the first to show that carrying the BDNF Val66Met polymorphisms partially compensates the decreased on HSv associated with APOE-ε4 in middle-age cognitively unimpaired individuals. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2 2020-01-01 2020 2020-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/236585 https://dx.doi.org/urn:doi:10.1007/s00429-020-02125-3 |
| url |
https://ddd.uab.cat/record/236585 https://dx.doi.org/urn:doi:10.1007/s00429-020-02125-3 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2018-038085-I Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 SLT002-16-00201 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 IEDI-2016-00690 European Commission https://doi.org/10.13039/501100000780 752310 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869415914587291648 |
| score |
15,300719 |