Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) - a cumulative environmental exposure score - was associated with impairments of neurocognition, social cognition, and...

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Detalles Bibliográficos
Autores: Fusar-Poli, L., Prachason, T., Erzin, G., Pries, L.-K., Brondino, N., Politi, P., Delespaul, P., Kenis, G., Luykx, J.J., Lin, B.D., Richards, A.L., Akdede, B., Binbay, T., Alt?nyazar, V., Yal?nçetin, B., Gümü?-Akay, G., Cihan, B., Soygür, H., Ula?, H., Cankurtaran, E.?., Kaymak, S.U., Mihaljevic, M.M., Andric-Petrovic, S., Mirjanic, T., Bernardo, M., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., García-Portilla, M.P., Sanjuan, J., Escarti, M.J., Santos, J.L., Jiménez-López, E., Arrojo Romero, Manuel, Carracedo Álvarez, Ángel, López, G., González Peñas, Javier, Parellada, M., Maric, N.P., Atba?o?lu, C., Üçok, A., Alptekin, K., Saka, M.C., Arango, C., O'Donovan, M., van Os, J., Rutten, B.P., Guloksuz, S.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21462
Acceso en línea:https://portalcientifico.sergas.gal//documentos/643af6631656ab66db7dfe01
http://hdl.handle.net/20.500.11940/21462
Access Level:acceso abierto
Palabra clave:Adult
Humans
Cognition
Cross-Sectional Studies
Exposome
Schizophrenia
Siblings
Case-Control Studies
Schizophrenic Psychology
Cognition Disorders
Male
Female
AS Santiago
CHUS
FPGMX
Descripción
Sumario:Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) - a cumulative environmental exposure score - was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group. Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI -0.76 to -0.03) and healthy controls (B=-0.63, 95% CI -1.06 to -0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings. Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.

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