Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing

The present work is a detailed analysis of the numerical and positional parameters of cell proliferation in all of the derivatives of the wing disk. We have made use of twin clones resulting from mitotic recombination events at three different ages of development. The interfaces between twin clones...

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Detalles Bibliográficos
Autores: Resino, Jaime, Salama-Cohen, Patricia, García-Bellido, Antonio
Tipo de recurso: artículo
Fecha de publicación:2002
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/48350
Acceso en línea:http://hdl.handle.net/10261/48350
Access Level:acceso embargado
Palabra clave:Drosophila
Wing
Cells
Mitochondria
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spelling Determining the role of patterned cell proliferation in the shape and size of the Drosophila wingResino, JaimeSalama-Cohen, PatriciaGarcía-Bellido, AntonioDrosophilaWingCellsMitochondriaThe present work is a detailed analysis of the numerical and positional parameters of cell proliferation in all of the derivatives of the wing disk. We have made use of twin clones resulting from mitotic recombination events at three different ages of development. The interfaces between twin clones indicate the relative position in the anlage of the mother cells. Interface types vary with age of clone initiation and with wing regions. They are indicative of the main allocation of postmitotic cells of the growing clones. Growth is exponential and intercalar, i.e., the progeny of ancestor cells becomes more and more separated. Clones are compact, indicating that daughter cells tend to remain side by side. The shape of the clones is wing region characteristic. Subpopulations of cells grow preferentially along veins and wing margins and show characteristic shapes in different pleural regions. The shape and size of the adult wing regions largely depend on the shape of clones and hence of the allocation of successive rounds of daughter cells. The role of mitogenic morphogens in wing size and shape is discussed.Peer reviewedNational Academy of Sciences (U.S.)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220122002info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/48350reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1073/pnas.072208199Síinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/483502026-05-22T06:33:51Z
dc.title.none.fl_str_mv Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
title Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
spellingShingle Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
Resino, Jaime
Drosophila
Wing
Cells
Mitochondria
title_short Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
title_full Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
title_fullStr Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
title_full_unstemmed Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
title_sort Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing
dc.creator.none.fl_str_mv Resino, Jaime
Salama-Cohen, Patricia
García-Bellido, Antonio
author Resino, Jaime
author_facet Resino, Jaime
Salama-Cohen, Patricia
García-Bellido, Antonio
author_role author
author2 Salama-Cohen, Patricia
García-Bellido, Antonio
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila
Wing
Cells
Mitochondria
topic Drosophila
Wing
Cells
Mitochondria
description The present work is a detailed analysis of the numerical and positional parameters of cell proliferation in all of the derivatives of the wing disk. We have made use of twin clones resulting from mitotic recombination events at three different ages of development. The interfaces between twin clones indicate the relative position in the anlage of the mother cells. Interface types vary with age of clone initiation and with wing regions. They are indicative of the main allocation of postmitotic cells of the growing clones. Growth is exponential and intercalar, i.e., the progeny of ancestor cells becomes more and more separated. Clones are compact, indicating that daughter cells tend to remain side by side. The shape of the clones is wing region characteristic. Subpopulations of cells grow preferentially along veins and wing margins and show characteristic shapes in different pleural regions. The shape and size of the adult wing regions largely depend on the shape of clones and hence of the allocation of successive rounds of daughter cells. The role of mitogenic morphogens in wing size and shape is discussed.
publishDate 2002
dc.date.none.fl_str_mv 2002
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/48350
url http://hdl.handle.net/10261/48350
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1073/pnas.072208199
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv National Academy of Sciences (U.S.)
publisher.none.fl_str_mv National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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