Lipid droplets provide metabolic flexibility for cancer progression

A hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the absence of extracellular nutrients or in stressful scenarios. To achieve this, cancer cells need large amounts of...

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Detalles Bibliográficos
Autores: Safi, Rémi, Menéndez Buján, Pablo, Pol i Sorolla, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Oviedo (UNIOVI)
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::353d9798088787adae57c24560c56525
Acceso en línea:https://hdl.handle.net/2445/229397
Access Level:acceso abierto
Palabra clave:Cèl·lules canceroses
Lípids
Proteïnes
Cancer cells
Lipids
Proteins
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spelling Lipid droplets provide metabolic flexibility for cancer progressionSafi, RémiMenéndez Buján, PabloPol i Sorolla, AlbertCèl·lules cancerosesLípidsProteïnesCancer cellsLipidsProteinsA hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the absence of extracellular nutrients or in stressful scenarios. To achieve this, cancer cells need large amounts of lipids to build membranes, synthesize lipid-derived molecules, and generate metabolic energy in the absence of other nutrients. Tumor cells potentiate strategies to obtain lipids from other cells, metabolic pathways to synthesize new lipids, and mechanisms for efficient storage, mobilization, and utilization of these lipids. Lipid droplets (LDs) are the organelles that collect and supply lipids in eukaryotes and it is increasingly recognized that the accumulation of LDs is a new hallmark of cancer cells. Furthermore, an active role of LD proteins in processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes of LD-resident proteins (perilipins, lipases, and acyl-CoA synthetases), we provide an overview of the contribution of LDs to cancer progression and discuss the role of LD proteins during the proliferation, invasion, metastasis, apoptosis, and stemness of cancer cells.FEBS Press2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/229397Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésReproducció del document publicat a: https://doi.org/10.1002/1873-3468.14820FEBS Letters, 2024, vol. 598, num.10, p. 1301-1327https://doi.org/10.1002/1873-3468.14820cc-by-nc-nd (c) Safi, Rémi et al., 2024https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:ubarcelona__::353d9798088787adae57c24560c565252026-05-27T06:46:51Z
dc.title.none.fl_str_mv Lipid droplets provide metabolic flexibility for cancer progression
title Lipid droplets provide metabolic flexibility for cancer progression
spellingShingle Lipid droplets provide metabolic flexibility for cancer progression
Safi, Rémi
Cèl·lules canceroses
Lípids
Proteïnes
Cancer cells
Lipids
Proteins
title_short Lipid droplets provide metabolic flexibility for cancer progression
title_full Lipid droplets provide metabolic flexibility for cancer progression
title_fullStr Lipid droplets provide metabolic flexibility for cancer progression
title_full_unstemmed Lipid droplets provide metabolic flexibility for cancer progression
title_sort Lipid droplets provide metabolic flexibility for cancer progression
dc.creator.none.fl_str_mv Safi, Rémi
Menéndez Buján, Pablo
Pol i Sorolla, Albert
author Safi, Rémi
author_facet Safi, Rémi
Menéndez Buján, Pablo
Pol i Sorolla, Albert
author_role author
author2 Menéndez Buján, Pablo
Pol i Sorolla, Albert
author2_role author
author
dc.subject.none.fl_str_mv Cèl·lules canceroses
Lípids
Proteïnes
Cancer cells
Lipids
Proteins
topic Cèl·lules canceroses
Lípids
Proteïnes
Cancer cells
Lipids
Proteins
description A hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the absence of extracellular nutrients or in stressful scenarios. To achieve this, cancer cells need large amounts of lipids to build membranes, synthesize lipid-derived molecules, and generate metabolic energy in the absence of other nutrients. Tumor cells potentiate strategies to obtain lipids from other cells, metabolic pathways to synthesize new lipids, and mechanisms for efficient storage, mobilization, and utilization of these lipids. Lipid droplets (LDs) are the organelles that collect and supply lipids in eukaryotes and it is increasingly recognized that the accumulation of LDs is a new hallmark of cancer cells. Furthermore, an active role of LD proteins in processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes of LD-resident proteins (perilipins, lipases, and acyl-CoA synthetases), we provide an overview of the contribution of LDs to cancer progression and discuss the role of LD proteins during the proliferation, invasion, metastasis, apoptosis, and stemness of cancer cells.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229397
url https://hdl.handle.net/2445/229397
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/1873-3468.14820
FEBS Letters, 2024, vol. 598, num.10, p. 1301-1327
https://doi.org/10.1002/1873-3468.14820
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Safi, Rémi et al., 2024
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Safi, Rémi et al., 2024
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv FEBS Press
publisher.none.fl_str_mv FEBS Press
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Oviedo (UNIOVI)
instname_str Universidad de Oviedo (UNIOVI)
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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