Cyclodextrin-Based Functional Glyconanomaterials

© 2020 by the authors.

Detalles Bibliográficos
Autores: Rivero-Barbarroja, Gonzalo, Benito, Juan M., Ortiz-Mellet, Carmen, García Fernández, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/225724
Acceso en línea:http://hdl.handle.net/10261/225724
Access Level:acceso abierto
Palabra clave:Cyclodextrins
Drug delivery
Gene delivery
Glyconanomaterials
Glyconanoparticles
Glycopolymers
Glycotargeting
Multivalency
Self-assembly
Supramolecular nanomaterials
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spelling Cyclodextrin-Based Functional GlyconanomaterialsRivero-Barbarroja, GonzaloBenito, Juan M.Ortiz-Mellet, CarmenGarcía Fernández, José ManuelCyclodextrinsDrug deliveryGene deliveryGlyconanomaterialsGlyconanoparticlesGlycopolymersGlycotargetingMultivalencySelf-assemblySupramolecular nanomaterials© 2020 by the authors.Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.This research was funded by the Ministerio de Ciencia, Innovación y Universidades and the Agencia Estatal de Investigación (project RTI2018-097609-B-C21), the Ministerio de Ciencia e Innovación (PID2019-105858RB-I00), and the European Regional Development Funds (FEDER-UE).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/225724reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097609-B-C21RTI2018-097609-B-C21/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105858RB-I00PID2019-105858RB-I00/AEI/10.13039/501100011033https://doi.org/10.3390/nano10122517Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2257242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cyclodextrin-Based Functional Glyconanomaterials
title Cyclodextrin-Based Functional Glyconanomaterials
spellingShingle Cyclodextrin-Based Functional Glyconanomaterials
Rivero-Barbarroja, Gonzalo
Cyclodextrins
Drug delivery
Gene delivery
Glyconanomaterials
Glyconanoparticles
Glycopolymers
Glycotargeting
Multivalency
Self-assembly
Supramolecular nanomaterials
title_short Cyclodextrin-Based Functional Glyconanomaterials
title_full Cyclodextrin-Based Functional Glyconanomaterials
title_fullStr Cyclodextrin-Based Functional Glyconanomaterials
title_full_unstemmed Cyclodextrin-Based Functional Glyconanomaterials
title_sort Cyclodextrin-Based Functional Glyconanomaterials
dc.creator.none.fl_str_mv Rivero-Barbarroja, Gonzalo
Benito, Juan M.
Ortiz-Mellet, Carmen
García Fernández, José Manuel
author Rivero-Barbarroja, Gonzalo
author_facet Rivero-Barbarroja, Gonzalo
Benito, Juan M.
Ortiz-Mellet, Carmen
García Fernández, José Manuel
author_role author
author2 Benito, Juan M.
Ortiz-Mellet, Carmen
García Fernández, José Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cyclodextrins
Drug delivery
Gene delivery
Glyconanomaterials
Glyconanoparticles
Glycopolymers
Glycotargeting
Multivalency
Self-assembly
Supramolecular nanomaterials
topic Cyclodextrins
Drug delivery
Gene delivery
Glyconanomaterials
Glyconanoparticles
Glycopolymers
Glycotargeting
Multivalency
Self-assembly
Supramolecular nanomaterials
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/225724
url http://hdl.handle.net/10261/225724
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097609-B-C21
RTI2018-097609-B-C21/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105858RB-I00
PID2019-105858RB-I00/AEI/10.13039/501100011033
https://doi.org/10.3390/nano10122517
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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