The effect of low-frequency functional variation on anti-tumor necrosis factor alpha (TNF) response in Crohn's disease (CD) patients remains unexplored. The objective of this study was to investigate the impact of functional rare variants in clinical response to anti-TNF therapy in CD.
Bibliographic Details
| Authors: |
Chaparro M,
Aterido A,
Guerra I,
Iborra M,
Cabriada JL,
Bujanda L,
Taxonera C,
García-Sánchez V,
Marín-Jiménez I,
Barreiro-de Acosta M,
Vera I,
Martín-Arranz MD,
Hernández-Breijo B,
Mesonero F,
Sempere L,
Gomollón F,
Hinojosa J,
Bermejo F,
Beltrán B,
Rodríguez-Pescador A,
Banales JM,
Olivares D,
Aguilar-Melero P,
Menchén L,
Ferreiro-Iglesias R,
Blazquez Gómez I,
Benitez García B,
Guijarro LG,
Marin AC,
Bernardo D,
Marsal S,
Julia A,
Gisbert JP |
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| Format: | article
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| Status: | Published version |
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| Publication Date: | 2019 |
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| Country: | España |
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| Institution: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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| Repository: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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| OAI Identifier: | oai:isabial.fundanetsuite.com:p5773 |
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| Online Access: | https://isabial.portalinvestigacion.com/publicaciones5773
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| Access Level: | Open access |
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| Keyword: | Crohn’s disease, adalimumab, genes, infliximab, tumor necrosis factor alpha, whole-genome analysis |
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