Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites
The development of bio-MOFs or MOF biocomposites through the combination of MOFs with biopolymers offers the possibility of expanding the potential applications of MOFs, making use of more environmentally benign processes and reagents and giving rise to a new generation of greener and more bio-orien...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/346792 |
| Acceso en línea: | http://hdl.handle.net/10261/346792 |
| Access Level: | acceso abierto |
| Palabra clave: | Biocomposites Composite materials Metal−organic frameworks Short peptides Supramolecular hydrogels |
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Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocompositesIllescas-López, S.Martin-Romera, Javier D.Mañas-Torres, Mari C.Lopez-Lopez, Modesto T.Cuerva, Juan M.Gavira Gallardo, J. A.Carmona, Francisco J.Álvarez de Cienfuegos, LuisBiocompositesComposite materialsMetal−organic frameworksShort peptidesSupramolecular hydrogelsThe development of bio-MOFs or MOF biocomposites through the combination of MOFs with biopolymers offers the possibility of expanding the potential applications of MOFs, making use of more environmentally benign processes and reagents and giving rise to a new generation of greener and more bio-oriented composite materials. Now, with the increasing use of MOFs for biotechnological applications, the development of new protocols and materials to obtain novel bio-MOFs compatible with biomedical or biotechnological uses is needed. Herein, and as a proof of concept, we have explored the possibility of using short-peptide supramolecular hydrogels as media to promote the growth of MOF particles, giving rise to a new family of bio-MOFs. Short-peptide supramolecular hydrogels are very versatile materials that have shown excellent in vitro and in vivo biomedical applications such as tissue engineering and drug delivery vehicles, among others. These peptides self-assemble by noncovalent interactions, and, as such, these hydrogels are easily reversible, being more biocompatible and biodegradable. These peptides can self-assemble by a multitude of stimuli, such as changes in pH, temperature, solvent, adding salts, enzymatic activity, and so forth. In this work, we have taken advantage of this ability to promote peptide self-assembly with some of the components required to form MOF particles, giving rise to more homogeneous and well-integrated composite materials. Hydrogel formation has been triggered using Zn salts, required to form ZIF-8, and formic acid, required to form MOF-808. Two different protocols for the in situ MOF growth have been developed. Finally, the MOF-808 composite hydrogel has been tested for the decontamination of water polluted with phosphate ions as well as for the catalytic degradation of toxic organophosphate methyl paraoxon in an unbuffered solution.This study was supported by grants PID2020-118498GB-I00 and PID2020-113608RB-I00 funded by MCIN/AEI/10.13039/501100011033, projects P18-FR-3533 and A-FQM-340-UGR20 by FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades (Spain) and Project PPJIA2021.20 by Universidad de Granada. F.J.C. is thankful for the financial support provided by the Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2019-EF-ST-888972-PSustMOF) within the European Union H2020 programme and EU FEDER. M.C.M.-T. acknowledges grant PRE2018-083773 funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”, Spain.American Chemical SocietyMinisterio de Ciencia e Innovación (España)European CommissionUniversidad de GranadaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420232024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/346792reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118498GB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113608RB-I00http://dx.doi.org/10.1021/acsami.3c06943Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3467922026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| title |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| spellingShingle |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites Illescas-López, S. Biocomposites Composite materials Metal−organic frameworks Short peptides Supramolecular hydrogels |
| title_short |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| title_full |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| title_fullStr |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| title_full_unstemmed |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| title_sort |
Short-peptide supramolecular hydrogels for in situ growth of metal-organic framework-peptide biocomposites |
| dc.creator.none.fl_str_mv |
Illescas-López, S. Martin-Romera, Javier D. Mañas-Torres, Mari C. Lopez-Lopez, Modesto T. Cuerva, Juan M. Gavira Gallardo, J. A. Carmona, Francisco J. Álvarez de Cienfuegos, Luis |
| author |
Illescas-López, S. |
| author_facet |
Illescas-López, S. Martin-Romera, Javier D. Mañas-Torres, Mari C. Lopez-Lopez, Modesto T. Cuerva, Juan M. Gavira Gallardo, J. A. Carmona, Francisco J. Álvarez de Cienfuegos, Luis |
| author_role |
author |
| author2 |
Martin-Romera, Javier D. Mañas-Torres, Mari C. Lopez-Lopez, Modesto T. Cuerva, Juan M. Gavira Gallardo, J. A. Carmona, Francisco J. Álvarez de Cienfuegos, Luis |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia e Innovación (España) European Commission Universidad de Granada Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Biocomposites Composite materials Metal−organic frameworks Short peptides Supramolecular hydrogels |
| topic |
Biocomposites Composite materials Metal−organic frameworks Short peptides Supramolecular hydrogels |
| description |
The development of bio-MOFs or MOF biocomposites through the combination of MOFs with biopolymers offers the possibility of expanding the potential applications of MOFs, making use of more environmentally benign processes and reagents and giving rise to a new generation of greener and more bio-oriented composite materials. Now, with the increasing use of MOFs for biotechnological applications, the development of new protocols and materials to obtain novel bio-MOFs compatible with biomedical or biotechnological uses is needed. Herein, and as a proof of concept, we have explored the possibility of using short-peptide supramolecular hydrogels as media to promote the growth of MOF particles, giving rise to a new family of bio-MOFs. Short-peptide supramolecular hydrogels are very versatile materials that have shown excellent in vitro and in vivo biomedical applications such as tissue engineering and drug delivery vehicles, among others. These peptides self-assemble by noncovalent interactions, and, as such, these hydrogels are easily reversible, being more biocompatible and biodegradable. These peptides can self-assemble by a multitude of stimuli, such as changes in pH, temperature, solvent, adding salts, enzymatic activity, and so forth. In this work, we have taken advantage of this ability to promote peptide self-assembly with some of the components required to form MOF particles, giving rise to more homogeneous and well-integrated composite materials. Hydrogel formation has been triggered using Zn salts, required to form ZIF-8, and formic acid, required to form MOF-808. Two different protocols for the in situ MOF growth have been developed. Finally, the MOF-808 composite hydrogel has been tested for the decontamination of water polluted with phosphate ions as well as for the catalytic degradation of toxic organophosphate methyl paraoxon in an unbuffered solution. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/346792 |
| url |
http://hdl.handle.net/10261/346792 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118498GB-I00 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113608RB-I00 http://dx.doi.org/10.1021/acsami.3c06943 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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American Chemical Society |
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American Chemical Society |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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