Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir

Genital herpes, caused by herpes simplex virus type 2 (HSV-2), affects nearly 500 million people, mostly women. Since the main route of transmission is sexual contact, the development of an acyclovir extended-release vaginal microbicide would be a suitable tool for the prevention of virus transmissi...

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Detalles Bibliográficos
Autores: Martín-Bartolomé, Laura, Ruiz Caro, Roberto, Veiga Ochoa, María Dolores, Notario Pérez, Fernando
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/109847
Acceso en línea:https://hdl.handle.net/20.500.14352/109847
Access Level:acceso abierto
Palabra clave:615.01/.03
Chitosan
Controlled release
Ethyl cellulose
HSV-2
Microbicides
Xanthan gum
Farmacología (Farmacia)
3209 Farmacología
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repository_id_str
spelling Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovirMartín-Bartolomé, LauraRuiz Caro, RobertoVeiga Ochoa, María DoloresNotario Pérez, Fernando615.01/.03ChitosanControlled releaseEthyl celluloseHSV-2MicrobicidesXanthan gumFarmacología (Farmacia)3209 FarmacologíaGenital herpes, caused by herpes simplex virus type 2 (HSV-2), affects nearly 500 million people, mostly women. Since the main route of transmission is sexual contact, the development of an acyclovir extended-release vaginal microbicide would be a suitable tool for the prevention of virus transmission. In this work, we evaluated the potential of three polymers with different characteristics (chitosan, xanthan gum and ethyl cellulose) for obtaining acyclovir extended-release vaginal tablets. By combining the polymers, certain useful synergies were observed to modify their mucoadhesive capacity and control drug release. In the swelling studies, it observed that a polyelectrolyte complex with more moderate swelling and sustained gelation was formed between chitosan and xanthan gum exclusively in acidic medium (simulated vaginal fluid). This complex allowed prolonging the mucoadhesion of the tablets in ex vivo studies performed with vaginal mucosa, which would translate into better retention in the vagina after administration. In addition, the combination of chitosan and xanthan gum allowed obtaining a controlled release of acyclovir for 5 days, regardless of the pH of the medium, which would guarantee that drug release continues even in the presence of seminal fluid.ElsevierUniversidad Complutense de Madrid20242024-09-3020242024-09-30journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/109847reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1098472026-06-02T12:44:21Z
dc.title.none.fl_str_mv Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
title Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
spellingShingle Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
Martín-Bartolomé, Laura
615.01/.03
Chitosan
Controlled release
Ethyl cellulose
HSV-2
Microbicides
Xanthan gum
Farmacología (Farmacia)
3209 Farmacología
title_short Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
title_full Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
title_fullStr Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
title_full_unstemmed Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
title_sort Evaluation of polymer combinations in vaginal mucoadhesive tablets for the extended release of acyclovir
dc.creator.none.fl_str_mv Martín-Bartolomé, Laura
Ruiz Caro, Roberto
Veiga Ochoa, María Dolores
Notario Pérez, Fernando
author Martín-Bartolomé, Laura
author_facet Martín-Bartolomé, Laura
Ruiz Caro, Roberto
Veiga Ochoa, María Dolores
Notario Pérez, Fernando
author_role author
author2 Ruiz Caro, Roberto
Veiga Ochoa, María Dolores
Notario Pérez, Fernando
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.01/.03
Chitosan
Controlled release
Ethyl cellulose
HSV-2
Microbicides
Xanthan gum
Farmacología (Farmacia)
3209 Farmacología
topic 615.01/.03
Chitosan
Controlled release
Ethyl cellulose
HSV-2
Microbicides
Xanthan gum
Farmacología (Farmacia)
3209 Farmacología
description Genital herpes, caused by herpes simplex virus type 2 (HSV-2), affects nearly 500 million people, mostly women. Since the main route of transmission is sexual contact, the development of an acyclovir extended-release vaginal microbicide would be a suitable tool for the prevention of virus transmission. In this work, we evaluated the potential of three polymers with different characteristics (chitosan, xanthan gum and ethyl cellulose) for obtaining acyclovir extended-release vaginal tablets. By combining the polymers, certain useful synergies were observed to modify their mucoadhesive capacity and control drug release. In the swelling studies, it observed that a polyelectrolyte complex with more moderate swelling and sustained gelation was formed between chitosan and xanthan gum exclusively in acidic medium (simulated vaginal fluid). This complex allowed prolonging the mucoadhesion of the tablets in ex vivo studies performed with vaginal mucosa, which would translate into better retention in the vagina after administration. In addition, the combination of chitosan and xanthan gum allowed obtaining a controlled release of acyclovir for 5 days, regardless of the pH of the medium, which would guarantee that drug release continues even in the presence of seminal fluid.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-09-30
2024
2024-09-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/109847
url https://hdl.handle.net/20.500.14352/109847
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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