The early development of the inner ear: the role of notch and fgf pathways in aerly otic neural versus non-neural patterning
Otic neuronal precursors are specified in the otic placode but interestingly do so only in the anterior domain of the otic placode, the proneural domain. In the present study, we have explored why only this territory has the competence to undergo neurogenesis, this means the early events of otic pro...
| Autor: | |
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/7121 |
| Acceso en línea: | http://www.tdx.cat/TDX-0401109-114317 http://hdl.handle.net/10803/7121 |
| Access Level: | acceso abierto |
| Palabra clave: | ratolí peix pollet embrió cultius d'embrió electroporació marcatge cellular Sox3 resctricció de llinatges Notch FGF territori no-neural neurona territori proneural regionalització oída Desenvolupament lineage restrictions embryo culturing cell labelling electroporation DiI mouse zebrafish chick embryo otic placode neurogenesis DAPT patterning signaling proneural Development 612 |
| Sumario: | Otic neuronal precursors are specified in the otic placode but interestingly do so only in the anterior domain of the otic placode, the proneural domain. In the present study, we have explored why only this territory has the competence to undergo neurogenesis, this means the early events of otic proneural regionalization and neural commitment. The proneural and non-neural domains presented complementary gene expression patterns of transcription factors and members of the Notch pathway. Overall, we propose that proneural character is acquired in the anterior territory by the action of localized ectodermal FGF8-FGF10 signaling that enhances Sox3 function. FGF signals through Sox3 activity would be essential for the specification of the proneural domain versus a non-neural territory, while Notch would be involved in refining this early regionalization. |
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