Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder
12 p.
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/63440 |
| Acceso en línea: | http://hdl.handle.net/10017/63440 https://dx.doi.org/10.3389/fpsyt.2020.591962 |
| Access Level: | acceso abierto |
| Palabra clave: | CD4+ lymphocytes LPS-binding protein chemorreceptors gut barrier interleukin 10 (IL10) major depressive disorder regulatory T lymphocytes (Treg) |
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Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorderÁlvarez de Mon Soto, Melchor|||0000-0003-1309-7510Gómez Lahoz, Ana María|||0000-0003-3981-5138Álvarez de Mon Ortega, Miguel ÁngelOrozco Sanmartín, ArántzazuLahera Forteza, GuillermoSosa Reina, María DoloresDíaz Martín, David|||0000-0002-5672-6658Albillos Martínez, Agustín|||0000-0001-9131-2592Quintero Gutiérrez del Álamo, Francisco JavierMolero Santos, PatricioMonserrat Sanz, Jorge|||0000-0003-1775-4645CD4+ lymphocytesLPS-binding proteinchemorreceptorsgut barrierinterleukin 10 (IL10)major depressive disorderregulatory T lymphocytes (Treg)12 p.Background: Major Depressive Disorder (MDD) is associated with both proinflammatory and adaptive immune response abnormalities. Regulatory T lymphocytes (Tregs), a subtype of CD4+ T cells, are relevant for maintaining immune-inflammatory system homeostasis and control of inflammation such as the kind potentially induced by the interactions between the intestinal microbiome and gut mucosa. We investigated the Treg population and its distribution along their stages of differentiation/activation, as well as its function in MDD patients without concomitant diseases. We also studied the potential association between Treg alterations, intestinal barrier damage, and bacterial translocation. Methods: 30 MDD patients and 20 healthy controls were studied. The levels of circulating CD25FoxP3+ Tregs and their distribution on the naïve (TN), effector (TE), central (TCM), and effector memory(TEM) differentiation/activation stages were analyzed using polychromatic flow cytometry. Chemokine receptors (CCR) 2, 5, and 6, and the intracytoplasmic IL-10 expression by the Tregs were also analyzed. The serum IL-10 was measured using Luminex. The serum levels of zonulin and the intestinal fatty acid-binding protein (I-FABP), both markers of gut barrier function, and the LPS-binding protein (LBP), a marker of bacterial translocation, were measured using an enzyme-linked immunosorbent assay. Results: MDD patients had increased number of circulating Tregs cells with enhanced number of Tregs at the TN, TE, TCM, and TEM stages. The percentage of Tregs cells at TN stage was significantly higher in MDD patients. The percentage of Tregs that expressed CCR2 and CCR6 was increased as well as those expressing IL-10. MDD patients had significantly increased levels of circulating I-FABP and LBP. MDD patients with high LBP levels had a significant reduction in the number of circulating Tregs compared to normal-LBP MDD patients. Conclusions: MDD patients showed an expansion of circulating Tregs and their CD25highFoxP3+ and CD25lowFoxP3+ subsets throughout the different stages of CD4+ T lymphocyte differentiation/activation. Tregs also showed an increased frequency of cells expressing CCR6 and CCR2. IL-10 Treg production was also enhanced in MDD patients that concurrently had increased serum IL-10 levels. However, this Treg expansion was blunted in MDD patients with gut barrier damage and increased bacterial translocation.Instituto de Salud Carlos III ; Comunidad de MadridMedicina y Especialidades Médicas20212021-01-08journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10017/63440https://dx.doi.org/10.3389/fpsyt.2020.591962reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/634402026-06-18T11:13:07Z |
| dc.title.none.fl_str_mv |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| title |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| spellingShingle |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder Álvarez de Mon Soto, Melchor|||0000-0003-1309-7510 CD4+ lymphocytes LPS-binding protein chemorreceptors gut barrier interleukin 10 (IL10) major depressive disorder regulatory T lymphocytes (Treg) |
| title_short |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| title_full |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| title_fullStr |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| title_full_unstemmed |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| title_sort |
Blunted expansion of regulatory T lymphocytes is associated with increased bacterial translocation in patients with major depressive disorder |
| dc.creator.none.fl_str_mv |
Álvarez de Mon Soto, Melchor|||0000-0003-1309-7510 Gómez Lahoz, Ana María|||0000-0003-3981-5138 Álvarez de Mon Ortega, Miguel Ángel Orozco Sanmartín, Arántzazu Lahera Forteza, Guillermo Sosa Reina, María Dolores Díaz Martín, David|||0000-0002-5672-6658 Albillos Martínez, Agustín|||0000-0001-9131-2592 Quintero Gutiérrez del Álamo, Francisco Javier Molero Santos, Patricio Monserrat Sanz, Jorge|||0000-0003-1775-4645 |
| author |
Álvarez de Mon Soto, Melchor|||0000-0003-1309-7510 |
| author_facet |
Álvarez de Mon Soto, Melchor|||0000-0003-1309-7510 Gómez Lahoz, Ana María|||0000-0003-3981-5138 Álvarez de Mon Ortega, Miguel Ángel Orozco Sanmartín, Arántzazu Lahera Forteza, Guillermo Sosa Reina, María Dolores Díaz Martín, David|||0000-0002-5672-6658 Albillos Martínez, Agustín|||0000-0001-9131-2592 Quintero Gutiérrez del Álamo, Francisco Javier Molero Santos, Patricio Monserrat Sanz, Jorge|||0000-0003-1775-4645 |
| author_role |
author |
| author2 |
Gómez Lahoz, Ana María|||0000-0003-3981-5138 Álvarez de Mon Ortega, Miguel Ángel Orozco Sanmartín, Arántzazu Lahera Forteza, Guillermo Sosa Reina, María Dolores Díaz Martín, David|||0000-0002-5672-6658 Albillos Martínez, Agustín|||0000-0001-9131-2592 Quintero Gutiérrez del Álamo, Francisco Javier Molero Santos, Patricio Monserrat Sanz, Jorge|||0000-0003-1775-4645 |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Medicina y Especialidades Médicas |
| dc.subject.none.fl_str_mv |
CD4+ lymphocytes LPS-binding protein chemorreceptors gut barrier interleukin 10 (IL10) major depressive disorder regulatory T lymphocytes (Treg) |
| topic |
CD4+ lymphocytes LPS-binding protein chemorreceptors gut barrier interleukin 10 (IL10) major depressive disorder regulatory T lymphocytes (Treg) |
| description |
12 p. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-08 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10017/63440 https://dx.doi.org/10.3389/fpsyt.2020.591962 |
| url |
http://hdl.handle.net/10017/63440 https://dx.doi.org/10.3389/fpsyt.2020.591962 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
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reponame:e_Buah Biblioteca Digital Universidad de Alcalá instname:Universidad de Alcalá (UAH) |
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Universidad de Alcalá (UAH) |
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e_Buah Biblioteca Digital Universidad de Alcalá |
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e_Buah Biblioteca Digital Universidad de Alcalá |
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1869415847776223232 |
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15,812429 |