Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study

Background: To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL). Methods: Between 1970 and 2000, 84 consecutive patients with PBL were treated in 20 institutions of the Rare Cancer Network. Forty-six patients had Ann Arbor stage IE, 33 stage IIE,...

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Autores: Jeanneret-Sozzi, Wendy, Taghian, Alphonse, Epelbaum, Ron, Poortmans, Philip, Zwahlen, Daniel, Amsler, Beat, Villette, Sylviane, Belkacémi, Yazid, Nguyen, Tan, Scalliet, Pierre, Maingon, Philippe, Gutiérrez Miguélez, Cristina, Gastelblum, Pauline, Krengli, Marco, Abi Raad, Rita, Ozsahin, Mahmut, Mirimanoff, René Olivier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/183806
Acesso em linha:https://hdl.handle.net/2445/183806
Access Level:acceso abierto
Palavra-chave:Càncer de mama
Mastectomia
Radioteràpia
Quimioteràpia del càncer
Breast cancer
Mastectomy
Radiotherapy
Cancer chemotherapy
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spelling Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network studyJeanneret-Sozzi, WendyTaghian, AlphonseEpelbaum, RonPoortmans, PhilipZwahlen, DanielAmsler, BeatVillette, SylvianeBelkacémi, YazidNguyen, TanScalliet, PierreMaingon, PhilippeGutiérrez Miguélez, CristinaGastelblum, PaulineKrengli, MarcoAbi Raad, RitaOzsahin, MahmutMirimanoff, René OlivierCàncer de mamaMastectomiaRadioteràpiaQuimioteràpia del càncerBreast cancerMastectomyRadiotherapyCancer chemotherapyBackground: To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL). Methods: Between 1970 and 2000, 84 consecutive patients with PBL were treated in 20 institutions of the Rare Cancer Network. Forty-six patients had Ann Arbor stage IE, 33 stage IIE, 1 stage IIIE, 2 stage IVE and 2 an unknown stage. Twenty-one underwent a mastectomy, 39 conservative surgery and 23 biopsy; 51 received radiotherapy (RT) with (n = 37) or without (n = 14) chemotherapy. Median RT dose was 40 Gy (range 12-55 Gy). Results: Ten (12%) patients progressed locally and 43 (55%) had a systemic relapse. Central nervous system (CNS) was the site of relapse in 12 (14%) cases. The 5-yr overall survival, lymphoma-specific survival, disease-free survival and local control rates were 53%, 59%, 41% and 87% respectively. In the univariate analyses, favorable prognostic factors were early stage, conservative surgery, RT administration and combined modality treatment. Multivariate analysis showed that early stage and the use of RT were favorable prognostic factors. Conclusion: The outcome of PBL is fair. Local control is excellent with RT or combined modality treatment but systemic relapses, including that in the CNS, occurs frequentlyBioMed Central2022202220082022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183806Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/1471-2407-8-86BMC Cancer, 2008, vol. 8, num. 86https://doi.org/10.1186/1471-2407-8-86cc-by (c) Jeanneret-Sozzi, Wendy et al., 2008https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1838062026-05-29T05:05:01Z
dc.title.none.fl_str_mv Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
title Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
spellingShingle Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
Jeanneret-Sozzi, Wendy
Càncer de mama
Mastectomia
Radioteràpia
Quimioteràpia del càncer
Breast cancer
Mastectomy
Radiotherapy
Cancer chemotherapy
title_short Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
title_full Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
title_fullStr Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
title_full_unstemmed Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
title_sort Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study
dc.creator.none.fl_str_mv Jeanneret-Sozzi, Wendy
Taghian, Alphonse
Epelbaum, Ron
Poortmans, Philip
Zwahlen, Daniel
Amsler, Beat
Villette, Sylviane
Belkacémi, Yazid
Nguyen, Tan
Scalliet, Pierre
Maingon, Philippe
Gutiérrez Miguélez, Cristina
Gastelblum, Pauline
Krengli, Marco
Abi Raad, Rita
Ozsahin, Mahmut
Mirimanoff, René Olivier
author Jeanneret-Sozzi, Wendy
author_facet Jeanneret-Sozzi, Wendy
Taghian, Alphonse
Epelbaum, Ron
Poortmans, Philip
Zwahlen, Daniel
Amsler, Beat
Villette, Sylviane
Belkacémi, Yazid
Nguyen, Tan
Scalliet, Pierre
Maingon, Philippe
Gutiérrez Miguélez, Cristina
Gastelblum, Pauline
Krengli, Marco
Abi Raad, Rita
Ozsahin, Mahmut
Mirimanoff, René Olivier
author_role author
author2 Taghian, Alphonse
Epelbaum, Ron
Poortmans, Philip
Zwahlen, Daniel
Amsler, Beat
Villette, Sylviane
Belkacémi, Yazid
Nguyen, Tan
Scalliet, Pierre
Maingon, Philippe
Gutiérrez Miguélez, Cristina
Gastelblum, Pauline
Krengli, Marco
Abi Raad, Rita
Ozsahin, Mahmut
Mirimanoff, René Olivier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de mama
Mastectomia
Radioteràpia
Quimioteràpia del càncer
Breast cancer
Mastectomy
Radiotherapy
Cancer chemotherapy
topic Càncer de mama
Mastectomia
Radioteràpia
Quimioteràpia del càncer
Breast cancer
Mastectomy
Radiotherapy
Cancer chemotherapy
description Background: To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL). Methods: Between 1970 and 2000, 84 consecutive patients with PBL were treated in 20 institutions of the Rare Cancer Network. Forty-six patients had Ann Arbor stage IE, 33 stage IIE, 1 stage IIIE, 2 stage IVE and 2 an unknown stage. Twenty-one underwent a mastectomy, 39 conservative surgery and 23 biopsy; 51 received radiotherapy (RT) with (n = 37) or without (n = 14) chemotherapy. Median RT dose was 40 Gy (range 12-55 Gy). Results: Ten (12%) patients progressed locally and 43 (55%) had a systemic relapse. Central nervous system (CNS) was the site of relapse in 12 (14%) cases. The 5-yr overall survival, lymphoma-specific survival, disease-free survival and local control rates were 53%, 59%, 41% and 87% respectively. In the univariate analyses, favorable prognostic factors were early stage, conservative surgery, RT administration and combined modality treatment. Multivariate analysis showed that early stage and the use of RT were favorable prognostic factors. Conclusion: The outcome of PBL is fair. Local control is excellent with RT or combined modality treatment but systemic relapses, including that in the CNS, occurs frequently
publishDate 2008
dc.date.none.fl_str_mv 2008
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183806
url https://hdl.handle.net/2445/183806
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1471-2407-8-86
BMC Cancer, 2008, vol. 8, num. 86
https://doi.org/10.1186/1471-2407-8-86
dc.rights.none.fl_str_mv cc-by (c) Jeanneret-Sozzi, Wendy et al., 2008
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Jeanneret-Sozzi, Wendy et al., 2008
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415846663684096
score 15,812429

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