The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

[EN] The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanis...

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Detalles Bibliográficos
Autores: Acevedo-León, Delia, Monzó-Beltrán, Lidia, Gómez-Abril, Segundo Ángel, Estañ-Capel, Nuria, Camarasa-Lillo, Natalia, Pérez-Ebri, Marisa Luisa, Escandón-Álvarez, Jorge, Alonso-Iglesias, Eulalia, Santaolaria-Ayora, María Luisa, Carbonell-Moncho, Araceli, Ventura-Gayete, Josep, Pla, Luis, Bagán-Debón, Leticia, Viña-Almunia, Aurora, Martínez-Santamaría, M. Amparo, Ruiz-Luque, María, Alonso-Fernández, Jorge, Bañuls, Celia, Sáez. Guillermo, Martínez-Bisbal, M.Carmen|||0000-0002-8526-4413, Martínez-Máñez, Ramón|||0000-0001-5873-9674
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/196942
Acceso en línea:https://riunet.upv.es/handle/10251/196942
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Oxidative stress
GSH
GSSG
GSSG/GSH redox state
Tumor markers
QUIMICA INORGANICA
Descripción
Sumario:[EN] The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC.

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