Effectiveness of annual flu vaccination until week four of season 2018/2019
Background: Annual flu vaccination is the most effective measure to prevent the disease and its complications. Vaccine effectiveness (EV) vanes from season to season, requiring annual re-evaluation. The objective of this work was to estimate the preliminary effectiveness of the influenza vaccine unt...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
| Repositorio: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| OAI Identifier: | oai:isabial.fundanetsuite.com:p5914 |
| Acceso en línea: | https://isabial.portalinvestigacion.com/publicaciones5914 |
| Access Level: | acceso abierto |
| Palabra clave: | Influenza Human Vaccination Influenza vaccines Vaccination coverage Treatment outcome |
| Sumario: | Background: Annual flu vaccination is the most effective measure to prevent the disease and its complications. Vaccine effectiveness (EV) vanes from season to season, requiring annual re-evaluation. The objective of this work was to estimate the preliminary effectiveness of the influenza vaccine until epidemiological week 4 of the 2018/2019 season, in patients admitted to a third level hospital. Methods: The Test Negative Design (TDN) was carried out at the Hospital General Umversitario de Alicante. Patients admitted with laboratory-confirmed influenza (RT-PCR positive for any influenza virus, in clinical sample of nasopharyngeal aspirate) and those with clinical suspicion of influenza and negative RT-PCR, from week 40 to week 4 of the 2018/2019 influenza season, were considered as controls. The vaccination coverage was calculated in the cases and in the controls, and the EV with its 95% confidence interval using the formula: EV = (1-Odds Ratio) x 100. Results: We included 524 patients: 58 cases and 466 controls. The overall EV for prevention of influenza cases was 42.5 % (95% CI -17.1 to 71.8) and for those over 1 year of age 63.7 % (95% CI 25.4 to 82.3). Conclusions: The 2018-2019 influenza vaccine is effective in preventing influenza cases in patients admitted up to week 4 of the 2018-19 season. Results are preliminary and may vary and should be re-evaluated at the end of the season. |
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