Incidence and management of patients with methotrexate delayed elimination in the clinical practice

High-dose methotrexate (HDMTX) is administered for the treatment of some cancers. HDMTX is usually safe but may crystallize in renal tubules causing acute kidney injury (AKI). Consequently, MTX elimination is delayed, resulting in a severe and life-threatening condition. No studies have been publish...

Descripción completa

Detalles Bibliográficos
Autores: Gros, Luis, Roldán-Pérez, Alicia|||0000-0003-1151-5678, Cabero-Martínez, Almudena, Domínguez-Pinilla, Nerea, De la Fuente, Adolfo, González Barca, Eva|||0000-0002-1323-1508, Tasso, María, Torrent, Montserrat|||0000-0003-1917-1056, Gallardo, Eva, del Cerro, Inés, Giró-Perafita, Ariadna, Badia, Xavier|||0000-0001-7568-2550
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:301683
Acceso en línea:https://ddd.uab.cat/record/301683
https://dx.doi.org/urn:doi:10.1177/10781552221079568
Access Level:acceso abierto
Palabra clave:High-dose methotrexate
Acute kidney injury
Clinical management
Epidemiology
Methotrexate delayed elimination
id ES_a7eba7becb91c0295c7bfaca348ff8c9
oai_identifier_str oai:ddd.uab.cat:301683
network_acronym_str ES
network_name_str España
repository_id_str
spelling Incidence and management of patients with methotrexate delayed elimination in the clinical practiceA Delphi studyGros, LuisRoldán-Pérez, Alicia|||0000-0003-1151-5678Cabero-Martínez, AlmudenaDomínguez-Pinilla, NereaDe la Fuente, AdolfoGonzález Barca, Eva|||0000-0002-1323-1508Tasso, MaríaTorrent, Montserrat|||0000-0003-1917-1056Gallardo, Evadel Cerro, InésGiró-Perafita, AriadnaBadia, Xavier|||0000-0001-7568-2550High-dose methotrexateAcute kidney injuryClinical managementEpidemiologyMethotrexate delayed eliminationHigh-dose methotrexate (HDMTX) is administered for the treatment of some cancers. HDMTX is usually safe but may crystallize in renal tubules causing acute kidney injury (AKI). Consequently, MTX elimination is delayed, resulting in a severe and life-threatening condition. No studies have been published about the impact of MTX toxicity in Spain. This study aims to estimate the incidence and management of MTX delayed elimination and toxicity. A two-round Delphi study was performed to reach consensus between 10 medical experts on haemato-oncology and paediatric oncology with experience in the management of HDMTX treated patients from leading Spanish hospitals. An online questionnaire was developed based on national and international guidelines and previous evidence regarding HDMTX-related toxicity. Consensus was established at 80% agreement. Median and interquartile ranges were calculated, and incidence data were extrapolated to the Spanish general population. Out of 1.475 patients estimated to receive HDMTX treatment annually in Spain, 27.5% present MTX delayed elimination and 11.6% develop HDMTX-induced AKI (35.4% with severe systemic toxicities (.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/301683https://dx.doi.org/urn:doi:10.1177/10781552221079568reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3016832026-06-06T12:50:31Z
dc.title.none.fl_str_mv Incidence and management of patients with methotrexate delayed elimination in the clinical practice
A Delphi study
title Incidence and management of patients with methotrexate delayed elimination in the clinical practice
spellingShingle Incidence and management of patients with methotrexate delayed elimination in the clinical practice
Gros, Luis
High-dose methotrexate
Acute kidney injury
Clinical management
Epidemiology
Methotrexate delayed elimination
title_short Incidence and management of patients with methotrexate delayed elimination in the clinical practice
title_full Incidence and management of patients with methotrexate delayed elimination in the clinical practice
title_fullStr Incidence and management of patients with methotrexate delayed elimination in the clinical practice
title_full_unstemmed Incidence and management of patients with methotrexate delayed elimination in the clinical practice
title_sort Incidence and management of patients with methotrexate delayed elimination in the clinical practice
dc.creator.none.fl_str_mv Gros, Luis
Roldán-Pérez, Alicia|||0000-0003-1151-5678
Cabero-Martínez, Almudena
Domínguez-Pinilla, Nerea
De la Fuente, Adolfo
González Barca, Eva|||0000-0002-1323-1508
Tasso, María
Torrent, Montserrat|||0000-0003-1917-1056
Gallardo, Eva
del Cerro, Inés
Giró-Perafita, Ariadna
Badia, Xavier|||0000-0001-7568-2550
author Gros, Luis
author_facet Gros, Luis
Roldán-Pérez, Alicia|||0000-0003-1151-5678
Cabero-Martínez, Almudena
Domínguez-Pinilla, Nerea
De la Fuente, Adolfo
González Barca, Eva|||0000-0002-1323-1508
Tasso, María
Torrent, Montserrat|||0000-0003-1917-1056
Gallardo, Eva
del Cerro, Inés
Giró-Perafita, Ariadna
Badia, Xavier|||0000-0001-7568-2550
author_role author
author2 Roldán-Pérez, Alicia|||0000-0003-1151-5678
Cabero-Martínez, Almudena
Domínguez-Pinilla, Nerea
De la Fuente, Adolfo
González Barca, Eva|||0000-0002-1323-1508
Tasso, María
Torrent, Montserrat|||0000-0003-1917-1056
Gallardo, Eva
del Cerro, Inés
Giró-Perafita, Ariadna
Badia, Xavier|||0000-0001-7568-2550
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv High-dose methotrexate
Acute kidney injury
Clinical management
Epidemiology
Methotrexate delayed elimination
topic High-dose methotrexate
Acute kidney injury
Clinical management
Epidemiology
Methotrexate delayed elimination
description High-dose methotrexate (HDMTX) is administered for the treatment of some cancers. HDMTX is usually safe but may crystallize in renal tubules causing acute kidney injury (AKI). Consequently, MTX elimination is delayed, resulting in a severe and life-threatening condition. No studies have been published about the impact of MTX toxicity in Spain. This study aims to estimate the incidence and management of MTX delayed elimination and toxicity. A two-round Delphi study was performed to reach consensus between 10 medical experts on haemato-oncology and paediatric oncology with experience in the management of HDMTX treated patients from leading Spanish hospitals. An online questionnaire was developed based on national and international guidelines and previous evidence regarding HDMTX-related toxicity. Consensus was established at 80% agreement. Median and interquartile ranges were calculated, and incidence data were extrapolated to the Spanish general population. Out of 1.475 patients estimated to receive HDMTX treatment annually in Spain, 27.5% present MTX delayed elimination and 11.6% develop HDMTX-induced AKI (35.4% with severe systemic toxicities (.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/301683
https://dx.doi.org/urn:doi:10.1177/10781552221079568
url https://ddd.uab.cat/record/301683
https://dx.doi.org/urn:doi:10.1177/10781552221079568
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415818395123712
score 15.812455

Similares en LA Referencia