The exo-chirality of the α-helix and its implications in peptide self-assembly

The alpha-helix has an unexplored potential to draw a second layer of chirality encoded in the order of the primary sequence. In this thesis, we have empirically and computationally demonstrated the existence of exo-helical architectures arising from the first six periodic repetition patterns i, i +...

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Detalles Bibliográficos
Autor: Martínez Parra, José María
Tipo de recurso: tesis doctoral
Fecha de publicación:2025
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:dnet:minerva_____::f4e03dd559d89f8b740d356b234d7655
Acceso en línea:https://hdl.handle.net/10347/41594
Access Level:acceso abierto
Palabra clave:Peptide
alpha-helix
chirality
coiled coil
circular dichroism
230418 Polipéptidos y proteínas
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spelling The exo-chirality of the α-helix and its implications in peptide self-assemblyMartínez Parra, José MaríaPeptidealpha-helixchiralitycoiled coilcircular dichroism230418 Polipéptidos y proteínasThe alpha-helix has an unexplored potential to draw a second layer of chirality encoded in the order of the primary sequence. In this thesis, we have empirically and computationally demonstrated the existence of exo-helical architectures arising from the first six periodic repetition patterns i, i +x, x = 2-7 in the sequence. A systematic study using a non-canonical chromophore residue with different spacer lengths revealed that a high exo-helix consistency is required to induce ordered coiled coils. Finally, we have also demonstrated for the first time that non-canonical exo-helical patterns can build coiled-coil structures. This study offers a novel perspective in the design of protein-based materials with promising structural and functional features.Bergueiro Álvarez, JuliánMontenegro García, JavierUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)Granja Guillán, Juan Ramón20252025-01-0120252025-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10347/41594reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:minerva_____::f4e03dd559d89f8b740d356b234d76552026-06-15T12:47:27Z
dc.title.none.fl_str_mv The exo-chirality of the α-helix and its implications in peptide self-assembly
title The exo-chirality of the α-helix and its implications in peptide self-assembly
spellingShingle The exo-chirality of the α-helix and its implications in peptide self-assembly
Martínez Parra, José María
Peptide
alpha-helix
chirality
coiled coil
circular dichroism
230418 Polipéptidos y proteínas
title_short The exo-chirality of the α-helix and its implications in peptide self-assembly
title_full The exo-chirality of the α-helix and its implications in peptide self-assembly
title_fullStr The exo-chirality of the α-helix and its implications in peptide self-assembly
title_full_unstemmed The exo-chirality of the α-helix and its implications in peptide self-assembly
title_sort The exo-chirality of the α-helix and its implications in peptide self-assembly
dc.creator.none.fl_str_mv Martínez Parra, José María
author Martínez Parra, José María
author_facet Martínez Parra, José María
author_role author
dc.contributor.none.fl_str_mv Bergueiro Álvarez, Julián
Montenegro García, Javier
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
Granja Guillán, Juan Ramón
dc.subject.none.fl_str_mv Peptide
alpha-helix
chirality
coiled coil
circular dichroism
230418 Polipéptidos y proteínas
topic Peptide
alpha-helix
chirality
coiled coil
circular dichroism
230418 Polipéptidos y proteínas
description The alpha-helix has an unexplored potential to draw a second layer of chirality encoded in the order of the primary sequence. In this thesis, we have empirically and computationally demonstrated the existence of exo-helical architectures arising from the first six periodic repetition patterns i, i +x, x = 2-7 in the sequence. A systematic study using a non-canonical chromophore residue with different spacer lengths revealed that a high exo-helix consistency is required to induce ordered coiled coils. Finally, we have also demonstrated for the first time that non-canonical exo-helical patterns can build coiled-coil structures. This study offers a novel perspective in the design of protein-based materials with promising structural and functional features.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/41594
url https://hdl.handle.net/10347/41594
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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