Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk

Rubín-García, M. (María)|||/items/11858de4-84ed-42e9-ad23-e1a14adf48f6; Vitelli-Storelli, F. (Facundo)|||/items/661cbdfb-0ca1-4bb0-b89f-7bb4b15e4055; Alvarez-Alvarez, L. (Laura)|||/items/98e56b51-aa1f-4498-afa4-26e93ad356d7; Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7; Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6; Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41; Hernáez, Á. (Álvaro)|||/items/add58cbf-43e4-40d8-a12d-0d211145a8ce; Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131; Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d; Wärnberg, J. (Julia)|||/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68; Vioque, J. (Jesús)|||/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ff; Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a; López-Miranda, J. (José)|||/items/4f655f19-45e0-474d-84e8-c4146e2f80be; Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265; Tinahones, F.J. (Francisco J.)|||/items/3c469348-deec-4066-bd93-383e05813c10; Serra-Majem, L. (Luis)|||/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7; Cano-Ibañez, N. (Naomi)|||/items/5af1b303-5617-4f66-ace4-8bc134271ca1; Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e; Marcos-Delgado, A. (Alba)|||/items/c090900e-194e-42e8-abc4-9c1d5f4b2145; Tresserra-Rimbau, A. (Anna)|||/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a; Pinto, X. (Xavier)|||/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b; Delgado-Rodríguez, M. (Miguel)|||/items/c2b016b0-0c9e-4863-a8e8-2e8f77c49a2d; Matía-Martín, P. (Pilar)|||/items/a3aa4e66-a420-4736-90db-67c318f8e4da; Vidal, J. (Josep)|||/items/d6726d60-5635-4d9b-bc17-38373121f507; Vázquez, C. (Clotilde)|||/items/8d0a4262-228e-46c7-a251-d8944ef45ead; Vazquez-Ruiz, Z. (Zenaida)|||/items/e5a694a6-8f33-4461-bfe1-4e9faea986ae; Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06; Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9; Bullón-Vela, M. V. (María Vanessa)|||/items/10ee1b1e-7218-4ada-b3ef-32ed3b5e1716; Cenoz-Osinaga, J.C. (Juan C.)|||/items/0f36e582-6c54-4776-a8fc-3aa0ed2ba3e7

Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperurice...

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Detalles Bibliográficos
Autores:	Rubín-García, M. (María)\|\|\|/items/11858de4-84ed-42e9-ad23-e1a14adf48f6, Vitelli-Storelli, F. (Facundo)\|\|\|/items/661cbdfb-0ca1-4bb0-b89f-7bb4b15e4055, Alvarez-Alvarez, L. (Laura)\|\|\|/items/98e56b51-aa1f-4498-afa4-26e93ad356d7, Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41, Hernáez, Á. (Álvaro)\|\|\|/items/add58cbf-43e4-40d8-a12d-0d211145a8ce, Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131, Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d, Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68, Vioque, J. (Jesús)\|\|\|/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ff, Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a, López-Miranda, J. (José)\|\|\|/items/4f655f19-45e0-474d-84e8-c4146e2f80be, Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265, Tinahones, F.J. (Francisco J.)\|\|\|/items/3c469348-deec-4066-bd93-383e05813c10, Serra-Majem, L. (Luis)\|\|\|/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7, Cano-Ibañez, N. (Naomi)\|\|\|/items/5af1b303-5617-4f66-ace4-8bc134271ca1, Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e, Marcos-Delgado, A. (Alba)\|\|\|/items/c090900e-194e-42e8-abc4-9c1d5f4b2145, Tresserra-Rimbau, A. (Anna)\|\|\|/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a, Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b, Delgado-Rodríguez, M. (Miguel)\|\|\|/items/c2b016b0-0c9e-4863-a8e8-2e8f77c49a2d, Matía-Martín, P. (Pilar)\|\|\|/items/a3aa4e66-a420-4736-90db-67c318f8e4da, Vidal, J. (Josep)\|\|\|/items/d6726d60-5635-4d9b-bc17-38373121f507, Vázquez, C. (Clotilde)\|\|\|/items/8d0a4262-228e-46c7-a251-d8944ef45ead, Vazquez-Ruiz, Z. (Zenaida)\|\|\|/items/e5a694a6-8f33-4461-bfe1-4e9faea986ae, Razquin-Burillo, C. (Cristina)\|\|\|/items/2b900a44-aca0-4449-9167-2756e88fae06, Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9, Bullón-Vela, M. V. (María Vanessa)\|\|\|/items/10ee1b1e-7218-4ada-b3ef-32ed3b5e1716, Cenoz-Osinaga, J.C. (Juan C.)\|\|\|/items/0f36e582-6c54-4776-a8fc-3aa0ed2ba3e7
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/123455
Acceso en línea:	https://hdl.handle.net/10171/123455
Access Level:	acceso abierto
Palabra clave:	Hyperuricemia Polyphenols Uric acid

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oai_identifier_str	oai:dadun.unav.edu:10171/123455
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
title	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
spellingShingle	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk Rubín-García, M. (María)\|\|\|/items/11858de4-84ed-42e9-ad23-e1a14adf48f6 Hyperuricemia Polyphenols Uric acid
title_short	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
title_full	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
title_fullStr	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
title_full_unstemmed	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
title_sort	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk
dc.creator.none.fl_str_mv	Rubín-García, M. (María)\|\|\|/items/11858de4-84ed-42e9-ad23-e1a14adf48f6 Vitelli-Storelli, F. (Facundo)\|\|\|/items/661cbdfb-0ca1-4bb0-b89f-7bb4b15e4055 Alvarez-Alvarez, L. (Laura)\|\|\|/items/98e56b51-aa1f-4498-afa4-26e93ad356d7 Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Hernáez, Á. (Álvaro)\|\|\|/items/add58cbf-43e4-40d8-a12d-0d211145a8ce Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131 Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68 Vioque, J. (Jesús)\|\|\|/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ff Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a López-Miranda, J. (José)\|\|\|/items/4f655f19-45e0-474d-84e8-c4146e2f80be Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Tinahones, F.J. (Francisco J.)\|\|\|/items/3c469348-deec-4066-bd93-383e05813c10 Serra-Majem, L. (Luis)\|\|\|/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7 Cano-Ibañez, N. (Naomi)\|\|\|/items/5af1b303-5617-4f66-ace4-8bc134271ca1 Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e Marcos-Delgado, A. (Alba)\|\|\|/items/c090900e-194e-42e8-abc4-9c1d5f4b2145 Tresserra-Rimbau, A. (Anna)\|\|\|/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b Delgado-Rodríguez, M. (Miguel)\|\|\|/items/c2b016b0-0c9e-4863-a8e8-2e8f77c49a2d Matía-Martín, P. (Pilar)\|\|\|/items/a3aa4e66-a420-4736-90db-67c318f8e4da Vidal, J. (Josep)\|\|\|/items/d6726d60-5635-4d9b-bc17-38373121f507 Vázquez, C. (Clotilde)\|\|\|/items/8d0a4262-228e-46c7-a251-d8944ef45ead Vazquez-Ruiz, Z. (Zenaida)\|\|\|/items/e5a694a6-8f33-4461-bfe1-4e9faea986ae Razquin-Burillo, C. (Cristina)\|\|\|/items/2b900a44-aca0-4449-9167-2756e88fae06 Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Bullón-Vela, M. V. (María Vanessa)\|\|\|/items/10ee1b1e-7218-4ada-b3ef-32ed3b5e1716 Cenoz-Osinaga, J.C. (Juan C.)\|\|\|/items/0f36e582-6c54-4776-a8fc-3aa0ed2ba3e7
author	Rubín-García, M. (María)\|\|\|/items/11858de4-84ed-42e9-ad23-e1a14adf48f6
author_facet	Rubín-García, M. (María)\|\|\|/items/11858de4-84ed-42e9-ad23-e1a14adf48f6 Vitelli-Storelli, F. (Facundo)\|\|\|/items/661cbdfb-0ca1-4bb0-b89f-7bb4b15e4055 Alvarez-Alvarez, L. (Laura)\|\|\|/items/98e56b51-aa1f-4498-afa4-26e93ad356d7 Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Hernáez, Á. (Álvaro)\|\|\|/items/add58cbf-43e4-40d8-a12d-0d211145a8ce Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131 Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68 Vioque, J. (Jesús)\|\|\|/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ff Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a López-Miranda, J. (José)\|\|\|/items/4f655f19-45e0-474d-84e8-c4146e2f80be Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Tinahones, F.J. (Francisco J.)\|\|\|/items/3c469348-deec-4066-bd93-383e05813c10 Serra-Majem, L. (Luis)\|\|\|/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7 Cano-Ibañez, N. (Naomi)\|\|\|/items/5af1b303-5617-4f66-ace4-8bc134271ca1 Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e Marcos-Delgado, A. (Alba)\|\|\|/items/c090900e-194e-42e8-abc4-9c1d5f4b2145 Tresserra-Rimbau, A. (Anna)\|\|\|/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b Delgado-Rodríguez, M. (Miguel)\|\|\|/items/c2b016b0-0c9e-4863-a8e8-2e8f77c49a2d Matía-Martín, P. (Pilar)\|\|\|/items/a3aa4e66-a420-4736-90db-67c318f8e4da Vidal, J. (Josep)\|\|\|/items/d6726d60-5635-4d9b-bc17-38373121f507 Vázquez, C. (Clotilde)\|\|\|/items/8d0a4262-228e-46c7-a251-d8944ef45ead Vazquez-Ruiz, Z. (Zenaida)\|\|\|/items/e5a694a6-8f33-4461-bfe1-4e9faea986ae Razquin-Burillo, C. (Cristina)\|\|\|/items/2b900a44-aca0-4449-9167-2756e88fae06 Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Bullón-Vela, M. V. (María Vanessa)\|\|\|/items/10ee1b1e-7218-4ada-b3ef-32ed3b5e1716 Cenoz-Osinaga, J.C. (Juan C.)\|\|\|/items/0f36e582-6c54-4776-a8fc-3aa0ed2ba3e7
author_role	author
author2	Vitelli-Storelli, F. (Facundo)\|\|\|/items/661cbdfb-0ca1-4bb0-b89f-7bb4b15e4055 Alvarez-Alvarez, L. (Laura)\|\|\|/items/98e56b51-aa1f-4498-afa4-26e93ad356d7 Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Hernáez, Á. (Álvaro)\|\|\|/items/add58cbf-43e4-40d8-a12d-0d211145a8ce Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131 Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68 Vioque, J. (Jesús)\|\|\|/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ff Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a López-Miranda, J. (José)\|\|\|/items/4f655f19-45e0-474d-84e8-c4146e2f80be Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Tinahones, F.J. (Francisco J.)\|\|\|/items/3c469348-deec-4066-bd93-383e05813c10 Serra-Majem, L. (Luis)\|\|\|/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7 Cano-Ibañez, N. (Naomi)\|\|\|/items/5af1b303-5617-4f66-ace4-8bc134271ca1 Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e Marcos-Delgado, A. (Alba)\|\|\|/items/c090900e-194e-42e8-abc4-9c1d5f4b2145 Tresserra-Rimbau, A. (Anna)\|\|\|/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b Delgado-Rodríguez, M. (Miguel)\|\|\|/items/c2b016b0-0c9e-4863-a8e8-2e8f77c49a2d Matía-Martín, P. (Pilar)\|\|\|/items/a3aa4e66-a420-4736-90db-67c318f8e4da Vidal, J. (Josep)\|\|\|/items/d6726d60-5635-4d9b-bc17-38373121f507 Vázquez, C. (Clotilde)\|\|\|/items/8d0a4262-228e-46c7-a251-d8944ef45ead Vazquez-Ruiz, Z. (Zenaida)\|\|\|/items/e5a694a6-8f33-4461-bfe1-4e9faea986ae Razquin-Burillo, C. (Cristina)\|\|\|/items/2b900a44-aca0-4449-9167-2756e88fae06 Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Bullón-Vela, M. V. (María Vanessa)\|\|\|/items/10ee1b1e-7218-4ada-b3ef-32ed3b5e1716 Cenoz-Osinaga, J.C. (Juan C.)\|\|\|/items/0f36e582-6c54-4776-a8fc-3aa0ed2ba3e7
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Hyperuricemia Polyphenols Uric acid
topic	Hyperuricemia Polyphenols Uric acid
description	Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/123455
url	https://hdl.handle.net/10171/123455
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley-Blackwell
publisher.none.fl_str_mv	Wiley-Blackwell
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular riskRubín-García, M. (María)\|\|\|/items/11858de4-84ed-42e9-ad23-e1a14adf48f6Vitelli-Storelli, F. (Facundo)\|\|\|/items/661cbdfb-0ca1-4bb0-b89f-7bb4b15e4055Alvarez-Alvarez, L. (Laura)\|\|\|/items/98e56b51-aa1f-4498-afa4-26e93ad356d7Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41Hernáez, Á. (Álvaro)\|\|\|/items/add58cbf-43e4-40d8-a12d-0d211145a8ceMartinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2dWärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68Vioque, J. (Jesús)\|\|\|/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ffRomaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680aLópez-Miranda, J. (José)\|\|\|/items/4f655f19-45e0-474d-84e8-c4146e2f80beEstruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265Tinahones, F.J. (Francisco J.)\|\|\|/items/3c469348-deec-4066-bd93-383e05813c10Serra-Majem, L. (Luis)\|\|\|/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7Cano-Ibañez, N. (Naomi)\|\|\|/items/5af1b303-5617-4f66-ace4-8bc134271ca1Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019eMarcos-Delgado, A. (Alba)\|\|\|/items/c090900e-194e-42e8-abc4-9c1d5f4b2145Tresserra-Rimbau, A. (Anna)\|\|\|/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46aPinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1bDelgado-Rodríguez, M. (Miguel)\|\|\|/items/c2b016b0-0c9e-4863-a8e8-2e8f77c49a2dMatía-Martín, P. (Pilar)\|\|\|/items/a3aa4e66-a420-4736-90db-67c318f8e4daVidal, J. (Josep)\|\|\|/items/d6726d60-5635-4d9b-bc17-38373121f507Vázquez, C. (Clotilde)\|\|\|/items/8d0a4262-228e-46c7-a251-d8944ef45eadVazquez-Ruiz, Z. (Zenaida)\|\|\|/items/e5a694a6-8f33-4461-bfe1-4e9faea986aeRazquin-Burillo, C. (Cristina)\|\|\|/items/2b900a44-aca0-4449-9167-2756e88fae06Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9Bullón-Vela, M. V. (María Vanessa)\|\|\|/items/10ee1b1e-7218-4ada-b3ef-32ed3b5e1716Cenoz-Osinaga, J.C. (Juan C.)\|\|\|/items/0f36e582-6c54-4776-a8fc-3aa0ed2ba3e7HyperuricemiaPolyphenolsUric acidBackground Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.Wiley-BlackwellDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/123455reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1234552026-06-21T12:47:57Z
score	15,812429

Association among polyphenol intake, uric acid, and hyperuricemia: a cross-sectional analysis in a population at high cardiovascular risk

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