The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD

Schedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5 mg/kg/d) for s...

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Autores: Daniels, Carter W., Sanabria, Federico, Ibias Martín, Javier, Miguens Vázquez, Miguel, Pellón Suárez de Puga, Ricardo
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Nacional de Educación a Distancia
Repositorio:e-spacio. Repositorio Institucional de la UNED
Idioma:inglés
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/12619
Acceso en línea:https://hdl.handle.net/20.500.14468/12619
Access Level:acceso abierto
Palabra clave:Schedule-induced polydipsia
Methylphenidate
Attention-deficit hyperactivity disorder Bouts
Spontaneously hypertensive rat
Wistar Kyoto rats
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spelling The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHDDaniels, Carter W.Sanabria, FedericoIbias Martín, JavierMiguens Vázquez, MiguelPellón Suárez de Puga, RicardoSchedule-induced polydipsiaMethylphenidateAttention-deficit hyperactivity disorder BoutsSpontaneously hypertensive ratWistar Kyoto ratsSchedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5 mg/kg/d) for six consecutive SIP sessions. A test to assess possible sensitization effects was also conducted four days after termination of the drug treatment. At baseline, FT 90-s produced longer and more frequent drinking episodes in SHR than in WKY. An analysis of the distribution of inter-lick intervals revealed that drinking was organized in bouts, which were shorter in SHR than in WKY. Across strains and schedules, MPH shifted drinking episodes towards the beginning of inter-food intervals, which may reflect a stimulant effect on SIP. MPH transiently reduced the frequency of drinking episodes in WKY in FT 30-s, and more permanently reduced the frequency of licking bouts in Wistar rats. MPH also increased the length of licking bouts in Wistar rats. Overall, SHR displayed a hyperactive-like pattern of drinking (frequent but short bouts), which 2.5 mg/kg MPH appears to reduce in WKY and Wistar but not in SHR rats. It appears that therapeutic effects of MPH on hyperactive-like SIP require higher doses in SHR relative to control strains.Elseviere-Spacio UNED20242024-05-2020172017-08-3020172017-08-30journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/12619reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/126192026-06-06T12:38:31Z
dc.title.none.fl_str_mv The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
title The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
spellingShingle The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
Daniels, Carter W.
Schedule-induced polydipsia
Methylphenidate
Attention-deficit hyperactivity disorder Bouts
Spontaneously hypertensive rat
Wistar Kyoto rats
title_short The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
title_full The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
title_fullStr The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
title_full_unstemmed The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
title_sort The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
dc.creator.none.fl_str_mv Daniels, Carter W.
Sanabria, Federico
Ibias Martín, Javier
Miguens Vázquez, Miguel
Pellón Suárez de Puga, Ricardo
author Daniels, Carter W.
author_facet Daniels, Carter W.
Sanabria, Federico
Ibias Martín, Javier
Miguens Vázquez, Miguel
Pellón Suárez de Puga, Ricardo
author_role author
author2 Sanabria, Federico
Ibias Martín, Javier
Miguens Vázquez, Miguel
Pellón Suárez de Puga, Ricardo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv e-Spacio UNED
dc.subject.none.fl_str_mv Schedule-induced polydipsia
Methylphenidate
Attention-deficit hyperactivity disorder Bouts
Spontaneously hypertensive rat
Wistar Kyoto rats
topic Schedule-induced polydipsia
Methylphenidate
Attention-deficit hyperactivity disorder Bouts
Spontaneously hypertensive rat
Wistar Kyoto rats
description Schedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5 mg/kg/d) for six consecutive SIP sessions. A test to assess possible sensitization effects was also conducted four days after termination of the drug treatment. At baseline, FT 90-s produced longer and more frequent drinking episodes in SHR than in WKY. An analysis of the distribution of inter-lick intervals revealed that drinking was organized in bouts, which were shorter in SHR than in WKY. Across strains and schedules, MPH shifted drinking episodes towards the beginning of inter-food intervals, which may reflect a stimulant effect on SIP. MPH transiently reduced the frequency of drinking episodes in WKY in FT 30-s, and more permanently reduced the frequency of licking bouts in Wistar rats. MPH also increased the length of licking bouts in Wistar rats. Overall, SHR displayed a hyperactive-like pattern of drinking (frequent but short bouts), which 2.5 mg/kg MPH appears to reduce in WKY and Wistar but not in SHR rats. It appears that therapeutic effects of MPH on hyperactive-like SIP require higher doses in SHR relative to control strains.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-08-30
2017
2017-08-30
2024
2024-05-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/12619
url https://hdl.handle.net/20.500.14468/12619
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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