Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study

Introduction: Atopic dermatitis (AD) is a chronic inflammatory condition associated with a signif-icant physical, psychological, and economic burden. This study aimed to determine the multidimen-sional impact of AD on patients and the Spanish healthcare system. Methods: The present multicenter descr...

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Autores: Dobao, PD, Barredo, LC, Salvador, JFS, Serra-Baldrich, E, Pinto, PH, Cano, NH, De Frutos, FJO, Gullón, GR, Belloso, RML, Ortega, IA, Quesada, AG, Gutiérrez, MG, Calzada, YG, Torredemer, DA, Felius, NL, Martin, IH, Laserna, FJR
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:dnet:isabial_____::b95eb49d4bca0479f1e6e9123120d65c
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones12495
https://dpcj.org/index.php/dpc/article/view/5538
Access Level:acceso abierto
Palabra clave:atopic dermatitis
pruritus
disease burden
quality of life
healthcare resources
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spelling Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional StudyDobao, PDBarredo, LCSalvador, JFSSerra-Baldrich, EPinto, PHCano, NHDe Frutos, FJOGullón, GRBelloso, RMLOrtega, IAQuesada, AGGutiérrez, MGCalzada, YGTorredemer, DAFelius, NLMartin, IHLaserna, FJRatopic dermatitispruritusdisease burdenquality of lifehealthcare resourcesIntroduction: Atopic dermatitis (AD) is a chronic inflammatory condition associated with a signif-icant physical, psychological, and economic burden. This study aimed to determine the multidimen-sional impact of AD on patients and the Spanish healthcare system. Methods: The present multicenter descriptive cross-sectional study was conducted at 12 Spanish sites to detect clinical practice assessments and validated patient-reported measures. Results: A total of 62 patients were included (54.8% males; mean age: 33.1 years). According to the validated Investigator Global Assessment scale for AD, 61.3% and 38.7% of patients had moderate and severe AD, respectively. AD involved a mean of 43.3% body surface area, with patients reporting a median of 4.0 flares in the past year. The mean Patient-Oriented Eczema Measure (POEM) question-naire score was 19.8, indicating severe eczema. In addition, 57.1% of patients reported daily pain from scratching or skin inflammation. The mean Dermatology Life Quality Index (DLQI) was 14.3, show-ing a strong AD impact on patients' quality of life, positively correlated with severity, pruritus, and pain. AD also affected work productivity and sleep, with over 50% of patients reporting impairments in daily activities. Treatment patterns showed predominant use of topical corticosteroids (81.5%). Al-though no patient required hospitalization in the previous year, 25% resorted to alternative therapies/ unlicensed products. Conclusions: AD profoundly impacts patients' quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.MATTIOLI 18852025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones12495https://dpcj.org/index.php/dpc/article/view/5538Dermatology Practical & ConceptualISSN: 21609381reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:isabial_____::b95eb49d4bca0479f1e6e9123120d65c2026-06-12T10:20:37Z
dc.title.none.fl_str_mv Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
title Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
spellingShingle Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
Dobao, PD
atopic dermatitis
pruritus
disease burden
quality of life
healthcare resources
title_short Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
title_full Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
title_fullStr Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
title_full_unstemmed Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
title_sort Patient Burden and Impact of Moderate-to-Severe Atopic Dermatitis in the Spanish Healthcare System: The APOLO Cross-Sectional Study
dc.creator.none.fl_str_mv Dobao, PD
Barredo, LC
Salvador, JFS
Serra-Baldrich, E
Pinto, PH
Cano, NH
De Frutos, FJO
Gullón, GR
Belloso, RML
Ortega, IA
Quesada, AG
Gutiérrez, MG
Calzada, YG
Torredemer, DA
Felius, NL
Martin, IH
Laserna, FJR
author Dobao, PD
author_facet Dobao, PD
Barredo, LC
Salvador, JFS
Serra-Baldrich, E
Pinto, PH
Cano, NH
De Frutos, FJO
Gullón, GR
Belloso, RML
Ortega, IA
Quesada, AG
Gutiérrez, MG
Calzada, YG
Torredemer, DA
Felius, NL
Martin, IH
Laserna, FJR
author_role author
author2 Barredo, LC
Salvador, JFS
Serra-Baldrich, E
Pinto, PH
Cano, NH
De Frutos, FJO
Gullón, GR
Belloso, RML
Ortega, IA
Quesada, AG
Gutiérrez, MG
Calzada, YG
Torredemer, DA
Felius, NL
Martin, IH
Laserna, FJR
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv atopic dermatitis
pruritus
disease burden
quality of life
healthcare resources
topic atopic dermatitis
pruritus
disease burden
quality of life
healthcare resources
description Introduction: Atopic dermatitis (AD) is a chronic inflammatory condition associated with a signif-icant physical, psychological, and economic burden. This study aimed to determine the multidimen-sional impact of AD on patients and the Spanish healthcare system. Methods: The present multicenter descriptive cross-sectional study was conducted at 12 Spanish sites to detect clinical practice assessments and validated patient-reported measures. Results: A total of 62 patients were included (54.8% males; mean age: 33.1 years). According to the validated Investigator Global Assessment scale for AD, 61.3% and 38.7% of patients had moderate and severe AD, respectively. AD involved a mean of 43.3% body surface area, with patients reporting a median of 4.0 flares in the past year. The mean Patient-Oriented Eczema Measure (POEM) question-naire score was 19.8, indicating severe eczema. In addition, 57.1% of patients reported daily pain from scratching or skin inflammation. The mean Dermatology Life Quality Index (DLQI) was 14.3, show-ing a strong AD impact on patients' quality of life, positively correlated with severity, pruritus, and pain. AD also affected work productivity and sleep, with over 50% of patients reporting impairments in daily activities. Treatment patterns showed predominant use of topical corticosteroids (81.5%). Al-though no patient required hospitalization in the previous year, 25% resorted to alternative therapies/ unlicensed products. Conclusions: AD profoundly impacts patients' quality of life and entails high economic costs. This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones12495
https://dpcj.org/index.php/dpc/article/view/5538
url https://isabial.portalinvestigacion.com/publicaciones12495
https://dpcj.org/index.php/dpc/article/view/5538
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MATTIOLI 1885
publisher.none.fl_str_mv MATTIOLI 1885
dc.source.none.fl_str_mv Dermatology Practical & Conceptual
ISSN: 21609381
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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