Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection

Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Univ...

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Autores: Soldevila-Boixader, Laura, Villanueva, Bernat, Ulldemolins, Marta, Benavent Palomares, Eva, Padullés Zamora, Ariadna, Ribera Puig, Alba, Borras, Irene, Ariza Cardenal, Javier, Murillo Rubio, Óscar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/177264
Acceso en línea:https://hdl.handle.net/2445/177264
Access Level:acceso abierto
Palabra clave:Pneumònia
Malalties bacterianes grampositives
Pneumonia
Gram-positive bacterial infections
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spelling Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular InfectionSoldevila-Boixader, LauraVillanueva, BernatUlldemolins, MartaBenavent Palomares, EvaPadullés Zamora, AriadnaRibera Puig, AlbaBorras, IreneAriza Cardenal, JavierMurillo Rubio, ÓscarPneumòniaMalalties bacterianes grampositivesPneumoniaGram-positive bacterial infectionsBackground: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014-December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) we identified 11 DEP cases (4.8%) and this percentage almost doubled in the subgroup of patients ≥70 years (8.1%). The risk factors for DEP were age ≥70 years (HR 10.19, 95%CI 1.28-80.93), therapy >14 days (7.71, 1.98-30.09) and total cumulative dose of daptomycin ≥10 g (5.30, 1.14-24.66). Conclusions: Clinicians should monitor cumulative daptomycin dosage to minimize DEP risk, and be cautious particularly in older patients when the total dose of daptomycin exceeds 10 g.MDPI2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/177264Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/antibiotics10040446Antibiotics, 2021, vol. 10, num. 4https://doi.org/10.3390/antibiotics10040446cc by (c) Soldevila et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1772642026-05-29T05:05:01Z
dc.title.none.fl_str_mv Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
title Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
spellingShingle Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
Soldevila-Boixader, Laura
Pneumònia
Malalties bacterianes grampositives
Pneumonia
Gram-positive bacterial infections
title_short Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
title_full Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
title_fullStr Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
title_full_unstemmed Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
title_sort Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection
dc.creator.none.fl_str_mv Soldevila-Boixader, Laura
Villanueva, Bernat
Ulldemolins, Marta
Benavent Palomares, Eva
Padullés Zamora, Ariadna
Ribera Puig, Alba
Borras, Irene
Ariza Cardenal, Javier
Murillo Rubio, Óscar
author Soldevila-Boixader, Laura
author_facet Soldevila-Boixader, Laura
Villanueva, Bernat
Ulldemolins, Marta
Benavent Palomares, Eva
Padullés Zamora, Ariadna
Ribera Puig, Alba
Borras, Irene
Ariza Cardenal, Javier
Murillo Rubio, Óscar
author_role author
author2 Villanueva, Bernat
Ulldemolins, Marta
Benavent Palomares, Eva
Padullés Zamora, Ariadna
Ribera Puig, Alba
Borras, Irene
Ariza Cardenal, Javier
Murillo Rubio, Óscar
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumònia
Malalties bacterianes grampositives
Pneumonia
Gram-positive bacterial infections
topic Pneumònia
Malalties bacterianes grampositives
Pneumonia
Gram-positive bacterial infections
description Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014-December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) we identified 11 DEP cases (4.8%) and this percentage almost doubled in the subgroup of patients ≥70 years (8.1%). The risk factors for DEP were age ≥70 years (HR 10.19, 95%CI 1.28-80.93), therapy >14 days (7.71, 1.98-30.09) and total cumulative dose of daptomycin ≥10 g (5.30, 1.14-24.66). Conclusions: Clinicians should monitor cumulative daptomycin dosage to minimize DEP risk, and be cautious particularly in older patients when the total dose of daptomycin exceeds 10 g.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177264
url https://hdl.handle.net/2445/177264
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antibiotics10040446
Antibiotics, 2021, vol. 10, num. 4
https://doi.org/10.3390/antibiotics10040446
dc.rights.none.fl_str_mv cc by (c) Soldevila et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Soldevila et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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