Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms

Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

Bibliographic Details
Author: Landa Medrano, Jon
Format: doctoral thesis
Status:Published version
Publication Date:2023
Country:España
Institution:CBUC, CESCA
Repository:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/693378
Online Access:http://hdl.handle.net/10803/693378
Access Level:Open access
Keyword:Neuroimmunologia
Neuroinmunología
Neuroimmunology
Receptors neurals
Neurorreceptores
Neural receptor
Encefalitis
Encephalitis
Ciències de la Salut
616.8
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oai_identifier_str oai:www.tdx.cat:10803/693378
network_acronym_str ES
network_name_str España
repository_id_str
spelling Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanismsLanda Medrano, JonNeuroimmunologiaNeuroinmunologíaNeuroimmunologyReceptors neuralsNeurorreceptoresNeural receptorEncefalitisEncephalitisCiències de la Salut616.8Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)[eng] Background: Autoimmune encephalitis is a new category of immune-mediated brain disorders characterized by the presence of antibodies targeting neurotransmitter receptors, ion channels, or neuronal cell-surface proteins. Most of these encephalitides were previously considered idiopathic, but systematic research in the last 16 years has led to the identification of new potentially pathogenic autoantibodies. Despite the advances in the field, there are still patients harboring uncharacterized antibodies with a clinical syndrome suggestive to be immune-mediated and a prominent or isolated cerebellar involvement. Recognition of these syndromes is critical, because patients can recover it they are treated promptly. Among the recently identified syndromes, anti-IgLON5 disease stands out from the rest. Despite strong evidence pointing towards an autoimmune etiology (specific HLA association and in vitro effect of autoantibodies), neuropathological investigations reveal the presence of phosphorylated tau deposits, indicating a possible neurodegenerative mechanism. Whether the disease is has an autoimmune or neurodegenerative etiology is yet to be established. Objectives: 1) To characterize the autoantibodies and define the clinical features of patients with antibody-mediated cerebellar ataxia; 2) To investigate the potential pathogenicity of these antibodies in hippocampal neurons and HEK293 cells expressing the target antigens; 3) To evaluate possible neurodegenerative events in hippocampal neurons after treatment with IgLON5 antibodies, and 4) To identify protein partners of IgLON5 and evaluate how autoantibodies can alter the interaction between them.Universitat de BarcelonaSabater Baudet, LidiaRodríguez Allué, Manuel JoséUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut202520252023info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion189 p.application/pdfhttp://hdl.handle.net/10803/693378TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésADVERTIMENT. Tots els drets reservats. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6933782026-06-14T12:46:07Z
dc.title.none.fl_str_mv Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
title Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
spellingShingle Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
Landa Medrano, Jon
Neuroimmunologia
Neuroinmunología
Neuroimmunology
Receptors neurals
Neurorreceptores
Neural receptor
Encefalitis
Encephalitis
Ciències de la Salut
616.8
title_short Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
title_full Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
title_fullStr Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
title_full_unstemmed Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
title_sort Identification of new autoimmune encephalitis and characterization of antibody-mediated mechanisms
dc.creator.none.fl_str_mv Landa Medrano, Jon
author Landa Medrano, Jon
author_facet Landa Medrano, Jon
author_role author
dc.contributor.none.fl_str_mv Sabater Baudet, Lidia
Rodríguez Allué, Manuel José
Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.subject.none.fl_str_mv Neuroimmunologia
Neuroinmunología
Neuroimmunology
Receptors neurals
Neurorreceptores
Neural receptor
Encefalitis
Encephalitis
Ciències de la Salut
616.8
topic Neuroimmunologia
Neuroinmunología
Neuroimmunology
Receptors neurals
Neurorreceptores
Neural receptor
Encefalitis
Encephalitis
Ciències de la Salut
616.8
description Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/693378
url http://hdl.handle.net/10803/693378
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 189 p.
application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415809339621376
score 15,811543

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