Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Ext...

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Autores: Afonso, Gonçalo J. M., Cavaleiro, Carla, Valero, Jorge, Mota, Sandra I., Ferreiro, Elisabete
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154969
Acceso en línea:http://hdl.handle.net/10366/154969
Access Level:acceso abierto
Palabra clave:amyotrophic lateral sclerosis
biomarkers
exosomes
extracellular vesicles
miRNA
neurodegenerative diseases
Amyotrophic Lateral Sclerosis
Biomarkers, Pharmacological
Exosomes
Neurodegenerative Diseases
2407 Biología Celular
32 Ciencias Médicas
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spelling Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent PerspectivesAfonso, Gonçalo J. M.Cavaleiro, CarlaValero, JorgeMota, Sandra I.Ferreiro, Elisabeteamyotrophic lateral sclerosisbiomarkersexosomesextracellular vesiclesmiRNAneurodegenerative diseasesAmyotrophic Lateral SclerosisBiomarkers, PharmacologicalExosomesNeurodegenerative Diseases2407 Biología Celular32 Ciencias MédicasAmyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.PTDC/BTM-ORG/0055/2021, UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020, 2022.13281.BD, DL57/2016/CP1448/CT0027, CEECIND/00322/2017, 2022.00011.CEECIND./Fundação para a Ciência e Tecnologia202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/154969reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1549692026-06-07T06:28:51Z
dc.title.none.fl_str_mv Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
title Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
spellingShingle Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
Afonso, Gonçalo J. M.
amyotrophic lateral sclerosis
biomarkers
exosomes
extracellular vesicles
miRNA
neurodegenerative diseases
Amyotrophic Lateral Sclerosis
Biomarkers, Pharmacological
Exosomes
Neurodegenerative Diseases
2407 Biología Celular
32 Ciencias Médicas
title_short Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
title_full Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
title_fullStr Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
title_full_unstemmed Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
title_sort Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
dc.creator.none.fl_str_mv Afonso, Gonçalo J. M.
Cavaleiro, Carla
Valero, Jorge
Mota, Sandra I.
Ferreiro, Elisabete
author Afonso, Gonçalo J. M.
author_facet Afonso, Gonçalo J. M.
Cavaleiro, Carla
Valero, Jorge
Mota, Sandra I.
Ferreiro, Elisabete
author_role author
author2 Cavaleiro, Carla
Valero, Jorge
Mota, Sandra I.
Ferreiro, Elisabete
author2_role author
author
author
author
dc.subject.none.fl_str_mv amyotrophic lateral sclerosis
biomarkers
exosomes
extracellular vesicles
miRNA
neurodegenerative diseases
Amyotrophic Lateral Sclerosis
Biomarkers, Pharmacological
Exosomes
Neurodegenerative Diseases
2407 Biología Celular
32 Ciencias Médicas
topic amyotrophic lateral sclerosis
biomarkers
exosomes
extracellular vesicles
miRNA
neurodegenerative diseases
Amyotrophic Lateral Sclerosis
Biomarkers, Pharmacological
Exosomes
Neurodegenerative Diseases
2407 Biología Celular
32 Ciencias Médicas
description Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/154969
url http://hdl.handle.net/10366/154969
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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