Periaqueductal gray matter echogenicity as a marker of migraine chronification
Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the echogenicity of the periaqueductal gray matter and the red nucleus in patients with migraine,...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:281328 |
| Acceso en línea: | https://ddd.uab.cat/record/281328 https://dx.doi.org/urn:doi:10.1186/s10194-023-01576-3 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic migraine Echogenicity Migraine Periaqueductal gray matter Transcranial sonography |
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Periaqueductal gray matter echogenicity as a marker of migraine chronificationa case control studyVilas Rolán, Dolores|||0000-0003-3084-053XRubio, SaraGea, MireiaRíos, José|||0000-0002-0716-8784Ispierto, LourdesHernández-Pérez, María|||0000-0001-8279-7954Paré-Curell, Martí|||0000-0002-0627-5350Millán, Mònica|||0000-0002-4692-5936Dorado Bouix, Laura|||0000-0003-1095-6797Chronic migraineEchogenicityMigrainePeriaqueductal gray matterTranscranial sonographyMigraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the echogenicity of the periaqueductal gray matter and the red nucleus in patients with migraine, by means of transcranial ultrasound. In this cross-sectional study, a group of patients with migraine (according to the International Classification of Headache Disorders) and a group of control subjects with comparable age-and-sex distribution were prospectively included. We evaluated the area and echogenicity of the periaqueductal gray matter and the red nucleus by means of transcranial ultrasound, both bedside and posteriorly analyzed with the medical image viewer Horos. We included 115 subjects: 65 patients with migraine (39 of them with chronic migraine and 26 with episodic migraine), and 50 controls. Median disease duration in patients with chronic migraine was 29 (IQR: 19; 40) years, with a median of 18 (IQR: 14; 27) days of migraine per month. The area of the periaqueductal gray matter was larger in patients with chronic migraine compared to episodic migraine and controls (0.15[95%CI 0.12;0.22]cm 2 ; 0.11[95%CI 0.10;0.14]cm 2 and 0.12[95%CI 0.09;0.15]cm 2, respectively; p = 0.043). Chronic migraine patients showed an intensity of the periaqueductal gray matter echogenicity lower than controls (90.57[95%CI 70.87;117.26] vs 109.56[95%CI 83.30;122.64]; p = 0.035). The coefficient of variation of periaqueductal gray matter echogenicity was the highest in chronic migraine patients (p = 0.009). No differences were observed regarding the area or intensity of red nucleus echogenicity among groups. Patients with chronic migraine showed a larger area of echogenicity of periaqueductal gray matter, a lower intensity of its echogenicity and a higher heterogenicity within this brainstem structure compared to patients with episodic migraine and controls. The echogenicity of the periaqueductal gray matter should be further investigated as a biomarker of migraine chronification. The online version contains supplementary material available at 10.1186/s10194-023-01576-3. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281328https://dx.doi.org/urn:doi:10.1186/s10194-023-01576-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2813282026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Periaqueductal gray matter echogenicity as a marker of migraine chronification a case control study |
| title |
Periaqueductal gray matter echogenicity as a marker of migraine chronification |
| spellingShingle |
Periaqueductal gray matter echogenicity as a marker of migraine chronification Vilas Rolán, Dolores|||0000-0003-3084-053X Chronic migraine Echogenicity Migraine Periaqueductal gray matter Transcranial sonography |
| title_short |
Periaqueductal gray matter echogenicity as a marker of migraine chronification |
| title_full |
Periaqueductal gray matter echogenicity as a marker of migraine chronification |
| title_fullStr |
Periaqueductal gray matter echogenicity as a marker of migraine chronification |
| title_full_unstemmed |
Periaqueductal gray matter echogenicity as a marker of migraine chronification |
| title_sort |
Periaqueductal gray matter echogenicity as a marker of migraine chronification |
| dc.creator.none.fl_str_mv |
Vilas Rolán, Dolores|||0000-0003-3084-053X Rubio, Sara Gea, Mireia Ríos, José|||0000-0002-0716-8784 Ispierto, Lourdes Hernández-Pérez, María|||0000-0001-8279-7954 Paré-Curell, Martí|||0000-0002-0627-5350 Millán, Mònica|||0000-0002-4692-5936 Dorado Bouix, Laura|||0000-0003-1095-6797 |
| author |
Vilas Rolán, Dolores|||0000-0003-3084-053X |
| author_facet |
Vilas Rolán, Dolores|||0000-0003-3084-053X Rubio, Sara Gea, Mireia Ríos, José|||0000-0002-0716-8784 Ispierto, Lourdes Hernández-Pérez, María|||0000-0001-8279-7954 Paré-Curell, Martí|||0000-0002-0627-5350 Millán, Mònica|||0000-0002-4692-5936 Dorado Bouix, Laura|||0000-0003-1095-6797 |
| author_role |
author |
| author2 |
Rubio, Sara Gea, Mireia Ríos, José|||0000-0002-0716-8784 Ispierto, Lourdes Hernández-Pérez, María|||0000-0001-8279-7954 Paré-Curell, Martí|||0000-0002-0627-5350 Millán, Mònica|||0000-0002-4692-5936 Dorado Bouix, Laura|||0000-0003-1095-6797 |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Chronic migraine Echogenicity Migraine Periaqueductal gray matter Transcranial sonography |
| topic |
Chronic migraine Echogenicity Migraine Periaqueductal gray matter Transcranial sonography |
| description |
Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the echogenicity of the periaqueductal gray matter and the red nucleus in patients with migraine, by means of transcranial ultrasound. In this cross-sectional study, a group of patients with migraine (according to the International Classification of Headache Disorders) and a group of control subjects with comparable age-and-sex distribution were prospectively included. We evaluated the area and echogenicity of the periaqueductal gray matter and the red nucleus by means of transcranial ultrasound, both bedside and posteriorly analyzed with the medical image viewer Horos. We included 115 subjects: 65 patients with migraine (39 of them with chronic migraine and 26 with episodic migraine), and 50 controls. Median disease duration in patients with chronic migraine was 29 (IQR: 19; 40) years, with a median of 18 (IQR: 14; 27) days of migraine per month. The area of the periaqueductal gray matter was larger in patients with chronic migraine compared to episodic migraine and controls (0.15[95%CI 0.12;0.22]cm 2 ; 0.11[95%CI 0.10;0.14]cm 2 and 0.12[95%CI 0.09;0.15]cm 2, respectively; p = 0.043). Chronic migraine patients showed an intensity of the periaqueductal gray matter echogenicity lower than controls (90.57[95%CI 70.87;117.26] vs 109.56[95%CI 83.30;122.64]; p = 0.035). The coefficient of variation of periaqueductal gray matter echogenicity was the highest in chronic migraine patients (p = 0.009). No differences were observed regarding the area or intensity of red nucleus echogenicity among groups. Patients with chronic migraine showed a larger area of echogenicity of periaqueductal gray matter, a lower intensity of its echogenicity and a higher heterogenicity within this brainstem structure compared to patients with episodic migraine and controls. The echogenicity of the periaqueductal gray matter should be further investigated as a biomarker of migraine chronification. The online version contains supplementary material available at 10.1186/s10194-023-01576-3. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/281328 https://dx.doi.org/urn:doi:10.1186/s10194-023-01576-3 |
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https://ddd.uab.cat/record/281328 https://dx.doi.org/urn:doi:10.1186/s10194-023-01576-3 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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