Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes

Cytotoxicity is a critical parameter for materials intended for biological applications, such as food packaging. Shape-memory polyurethanes (SMPUs) have garnered significant interest due to their versatile properties and adaptability in synthesis. However, their suitability for biological applicatio...

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Autores: Veloso-Fernández, Antonio, Laza, José Manuel, Ruiz-Rubio, Leire, Martín, Ane, Benito-Vicente, Asier, Martín, César, Vilas-Vilela, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/372785
Acceso en línea:http://hdl.handle.net/10261/372785
https://api.elsevier.com/content/abstract/scopus_id/85206450880
Access Level:acceso abierto
Palabra clave:Shape-memory polyurethanes
Castor oil
Non-cytotoxic polymers
Packaging
Isophorone diisocyanate
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spelling Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory PolyurethanesVeloso-Fernández, AntonioLaza, José ManuelRuiz-Rubio, LeireMartín, AneBenito-Vicente, AsierMartín, CésarVilas-Vilela, José LuisShape-memory polyurethanesCastor oilNon-cytotoxic polymersPackagingIsophorone diisocyanateCytotoxicity is a critical parameter for materials intended for biological applications, such as food packaging. Shape-memory polyurethanes (SMPUs) have garnered significant interest due to their versatile properties and adaptability in synthesis. However, their suitability for biological applications is limited by the use of aromatic isocyanates, such as methylene diphenyl 4,4'-diisocyanate (MDI) and toluene diisocyanate (TDI), which are commonly used in SMPU synthesis but can generate carcinogenic compounds upon degradation. In this study, thermo-responsive shape-memory polyurethanes (SMPUs) were synthesized using poly(tetramethylene ether) glycol (PTMG) and castor oil (CO) as a chain extender with four different isocyanates-aromatic (MDI and TDI), aliphatic (hexamethylene diisocyanate [HDI] and isophorone diisocyanate [IPDI])-to evaluate their impact on polyurethane cytotoxicity. Cytotoxicity assays were conducted on the synthesized SMPU samples before and after exposure to light-induced degradation. The results showed that prior to degradation, all samples exhibited cell proliferation rates above 90%. However, after degradation, the SMPUs containing aromatic isocyanates demonstrated a drastic reduction in cell proliferation to values below 10%, whereas the samples with aliphatic isocyanates maintained cell proliferation above 70%. Subsequently, the influence of polyol chain length was assessed using PTMG, with molecular weights of 1000, 650, and 250 g·mol-1. The results indicated that the SMPUs with longer chain lengths exhibited higher cell proliferation rates both before and after degradation. The thermal and mechanical properties of the SMPUs were further characterized using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermomechanical analysis (TMA), providing comprehensive insights into the behavior of these materials.The authors are thankful for funding from the Government of the Basque Country under the Grupos de Investigación del Sistema Universitario Vasco (IT1756-22) program and the ELKARTEK programPeer reviewedMultidisciplinary Digital Publishing InstituteEusko JaurlaritzaVeloso-Fernández, Antonio [0000-0003-1309-2373]Ruiz-Rubio, Leire [0000-0002-2045-008X]Martín, César [0000-0002-4087-8729]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/372785https://api.elsevier.com/content/abstract/scopus_id/85206450880reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/ma17194770https://doi.org/10.3390/ma17194770Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3727852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
title Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
spellingShingle Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
Veloso-Fernández, Antonio
Shape-memory polyurethanes
Castor oil
Non-cytotoxic polymers
Packaging
Isophorone diisocyanate
title_short Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
title_full Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
title_fullStr Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
title_full_unstemmed Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
title_sort Advancing Food Packaging: Exploring Cyto-Toxicity of Shape Memory Polyurethanes
dc.creator.none.fl_str_mv Veloso-Fernández, Antonio
Laza, José Manuel
Ruiz-Rubio, Leire
Martín, Ane
Benito-Vicente, Asier
Martín, César
Vilas-Vilela, José Luis
author Veloso-Fernández, Antonio
author_facet Veloso-Fernández, Antonio
Laza, José Manuel
Ruiz-Rubio, Leire
Martín, Ane
Benito-Vicente, Asier
Martín, César
Vilas-Vilela, José Luis
author_role author
author2 Laza, José Manuel
Ruiz-Rubio, Leire
Martín, Ane
Benito-Vicente, Asier
Martín, César
Vilas-Vilela, José Luis
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Eusko Jaurlaritza
Veloso-Fernández, Antonio [0000-0003-1309-2373]
Ruiz-Rubio, Leire [0000-0002-2045-008X]
Martín, César [0000-0002-4087-8729]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Shape-memory polyurethanes
Castor oil
Non-cytotoxic polymers
Packaging
Isophorone diisocyanate
topic Shape-memory polyurethanes
Castor oil
Non-cytotoxic polymers
Packaging
Isophorone diisocyanate
description Cytotoxicity is a critical parameter for materials intended for biological applications, such as food packaging. Shape-memory polyurethanes (SMPUs) have garnered significant interest due to their versatile properties and adaptability in synthesis. However, their suitability for biological applications is limited by the use of aromatic isocyanates, such as methylene diphenyl 4,4'-diisocyanate (MDI) and toluene diisocyanate (TDI), which are commonly used in SMPU synthesis but can generate carcinogenic compounds upon degradation. In this study, thermo-responsive shape-memory polyurethanes (SMPUs) were synthesized using poly(tetramethylene ether) glycol (PTMG) and castor oil (CO) as a chain extender with four different isocyanates-aromatic (MDI and TDI), aliphatic (hexamethylene diisocyanate [HDI] and isophorone diisocyanate [IPDI])-to evaluate their impact on polyurethane cytotoxicity. Cytotoxicity assays were conducted on the synthesized SMPU samples before and after exposure to light-induced degradation. The results showed that prior to degradation, all samples exhibited cell proliferation rates above 90%. However, after degradation, the SMPUs containing aromatic isocyanates demonstrated a drastic reduction in cell proliferation to values below 10%, whereas the samples with aliphatic isocyanates maintained cell proliferation above 70%. Subsequently, the influence of polyol chain length was assessed using PTMG, with molecular weights of 1000, 650, and 250 g·mol-1. The results indicated that the SMPUs with longer chain lengths exhibited higher cell proliferation rates both before and after degradation. The thermal and mechanical properties of the SMPUs were further characterized using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermomechanical analysis (TMA), providing comprehensive insights into the behavior of these materials.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/372785
https://api.elsevier.com/content/abstract/scopus_id/85206450880
url http://hdl.handle.net/10261/372785
https://api.elsevier.com/content/abstract/scopus_id/85206450880
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/ma17194770
https://doi.org/10.3390/ma17194770
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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