Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis

OBJECTIVE: To determine whether kidney function independently relates to endothelial activation and ultrasound determined carotid atherosclerosis in black and white Africans with rheumatoid arthritis (RA). METHODS: We calculated the Jelliffe, 5 Cockcroft-Gault equations, Salazar-Corcoran, Modificati...

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Authors: Dessein, Patrick H., Hsu, Hon-Chun, Tsang, Linda, Millen, Aletta M.E., Woodiwiss, Angela J., Norton, Gavin R., Solomon, Ahmed, González-Gay Mantecón, Miguel Ángel
Format: article
Publication Date:2015
Country:España
Institution:Universidad de Cantabria (UC)
Repository:UCrea Repositorio Abierto de la Universidad de Cantabria
Language:English
OAI Identifier:oai:repositorio.unican.es:10902/10169
Online Access:http://hdl.handle.net/10902/10169
Access Level:Open access
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spelling Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritisDessein, Patrick H.Hsu, Hon-ChunTsang, LindaMillen, Aletta M.E.Woodiwiss, Angela J.Norton, Gavin R.Solomon, AhmedGonzález-Gay Mantecón, Miguel ÁngelOBJECTIVE: To determine whether kidney function independently relates to endothelial activation and ultrasound determined carotid atherosclerosis in black and white Africans with rheumatoid arthritis (RA). METHODS: We calculated the Jelliffe, 5 Cockcroft-Gault equations, Salazar-Corcoran, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (EGFR) equations in 233 (112 black) RA patients. RESULTS: The CKD-EPI eGFR was <90 ml/min/1.73m2 in 49.1% and 30.6% of black and white patients, respectively (odds ratio (95% confidence interval) = 2.19 (1.28-3.75), p = 0.004). EGFRs were overall consistently associated with monocyte chemoattractant protein-1 and angiopoietin 2 concentrations in white patients, and with carotid intima-media thickness and plaque in black participants. Amongst black patients, plaque prevalence was 36.7% and the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was not associated with plaque presence for the MDRD equation (p = 0.3), whereas the respective relationship was significant or borderline significant (p = 0.003 to 0.08) and of similar extent (p>0.1 for comparisons of AUC (SE)) for the other 8 equations. Based on optimal eGFR cutoff values with sensitivities and specificities ranging from 42 to 60% and 70 to 91% respectively, as determined in ROC curve analysis, a low eGFR increased the odds ratio for plaque 2.2 to 4.0 fold. CONCLUSION: Reduced kidney function is independently associated with atherosclerosis and endothelial activation in black and white Africans with RA, respectively. CKD is highly prevalent in black Africans with RA. Apart from the MDRD, eGFR equations are useful in predicting carotid plaque presence, a coronary heart disease equivalent, amongst black African RA patients.Public Library of ScienceUniversidad de Cantabria20152015-03-25journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/10169PLoS One. 2015 Mar 25;10(3):e0121693reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/101692026-06-02T12:39:31Z
dc.title.none.fl_str_mv Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
title Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
spellingShingle Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
Dessein, Patrick H.
title_short Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
title_full Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
title_fullStr Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
title_full_unstemmed Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
title_sort Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis
dc.creator.none.fl_str_mv Dessein, Patrick H.
Hsu, Hon-Chun
Tsang, Linda
Millen, Aletta M.E.
Woodiwiss, Angela J.
Norton, Gavin R.
Solomon, Ahmed
González-Gay Mantecón, Miguel Ángel
author Dessein, Patrick H.
author_facet Dessein, Patrick H.
Hsu, Hon-Chun
Tsang, Linda
Millen, Aletta M.E.
Woodiwiss, Angela J.
Norton, Gavin R.
Solomon, Ahmed
González-Gay Mantecón, Miguel Ángel
author_role author
author2 Hsu, Hon-Chun
Tsang, Linda
Millen, Aletta M.E.
Woodiwiss, Angela J.
Norton, Gavin R.
Solomon, Ahmed
González-Gay Mantecón, Miguel Ángel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
description OBJECTIVE: To determine whether kidney function independently relates to endothelial activation and ultrasound determined carotid atherosclerosis in black and white Africans with rheumatoid arthritis (RA). METHODS: We calculated the Jelliffe, 5 Cockcroft-Gault equations, Salazar-Corcoran, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (EGFR) equations in 233 (112 black) RA patients. RESULTS: The CKD-EPI eGFR was <90 ml/min/1.73m2 in 49.1% and 30.6% of black and white patients, respectively (odds ratio (95% confidence interval) = 2.19 (1.28-3.75), p = 0.004). EGFRs were overall consistently associated with monocyte chemoattractant protein-1 and angiopoietin 2 concentrations in white patients, and with carotid intima-media thickness and plaque in black participants. Amongst black patients, plaque prevalence was 36.7% and the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was not associated with plaque presence for the MDRD equation (p = 0.3), whereas the respective relationship was significant or borderline significant (p = 0.003 to 0.08) and of similar extent (p>0.1 for comparisons of AUC (SE)) for the other 8 equations. Based on optimal eGFR cutoff values with sensitivities and specificities ranging from 42 to 60% and 70 to 91% respectively, as determined in ROC curve analysis, a low eGFR increased the odds ratio for plaque 2.2 to 4.0 fold. CONCLUSION: Reduced kidney function is independently associated with atherosclerosis and endothelial activation in black and white Africans with RA, respectively. CKD is highly prevalent in black Africans with RA. Apart from the MDRD, eGFR equations are useful in predicting carotid plaque presence, a coronary heart disease equivalent, amongst black African RA patients.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-03-25
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/10169
url http://hdl.handle.net/10902/10169
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv PLoS One. 2015 Mar 25;10(3):e0121693
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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