Determination of atrazine and propazine metabolites deemed endocrine disruptors in human seminal plasma by LC–ESI-MS/MS

[Background] The increasing prevalence of male infertility and the declining trend in sperm quality has been associated to compounds known as “endocrine-disruptors”. The proven endocrine-disrupting effects of atrazine and propazine herbicides led us to conduct long-term research based on highly accu...

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Detalles Bibliográficos
Autores: Rodríguez-Robledo, Virginia, Vendrell, Alberto, García-Cifuentes, Alicia, Villaseca-González, Noemí, Guiberteau-Cabanillas, Carmen, Luque Martínez, Lydia, Garde, José Julián, Fernández-Santos, M. Rocío
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/278811
Acceso en línea:http://hdl.handle.net/10261/278811
Access Level:acceso abierto
Descripción
Sumario:[Background] The increasing prevalence of male infertility and the declining trend in sperm quality has been associated to compounds known as “endocrine-disruptors”. The proven endocrine-disrupting effects of atrazine and propazine herbicides led us to conduct long-term research based on highly accurate specific analytical methods with a view to confirming the suspected association. Among the proposed developments was a sensitive analytical method for the simultaneous determination of three metabolites of atrazine and propazine.