Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain

A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV...

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Autores: Càmara Mas, Jordi, Marimón, José María, Cercenado, Emilia, Larrosa, Nieves, Quesada, María Dolores, Fontanals, Dionísia, Cubero, Meritxell, Pérez Trallero, Emilio, Fenoll, Asunción, Liñares Louzao, Josefina, Ardanuy Tisaire, María Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/130801
Acceso en línea:https://hdl.handle.net/2445/130801
Access Level:acceso abierto
Palabra clave:Pneumònia
Vacunes
Espanya
Infeccions per pneumococs
Pneumonia
Vaccines
Spain
Pneumococcal Infections
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spelling Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in SpainCàmara Mas, JordiMarimón, José MaríaCercenado, EmiliaLarrosa, NievesQuesada, María DoloresFontanals, DionísiaCubero, MeritxellPérez Trallero, EmilioFenoll, AsunciónLiñares Louzao, JosefinaArdanuy Tisaire, María CarmenPneumòniaVacunesEspanyaInfeccions per pneumococsPneumoniaVaccinesSpainPneumococcal InfectionsA prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV13 introduction for children on adult IPD. A total of 1558 IPD episodes were detected. The incidence of IPD decreased significantly in the second period by-33.9% (95% CI,-40.3% to-26.8%). IPD due to PCV7 serotypes (-52.7%; 95% CI,-64.2% to-37.5%) and to PCV13 additional serotypes (-55.0% 95% CI, -62.0% to-46.7%) significantly decreased whereas IPD due to non-PCV13 serotypes remained stable (1.0% 95% CI,-12.9% to 17.2%). IPD due to all PCV13 additional serotypes significantly declined with the exception of serotype 3 (-11.3%; 95% CI-35.0% to 21.1%). IPD due to two non-PCV13 serotypes varied: serotype 6C that rose (301.6%; 95% CI, 92.7% to 733.3%, p<0.001), related to the expansion of ST386(6C), and serotype 8 that decreased (-34.9%, 95% CI,-57.1 to-1.2, p = 0.049), related to a decline of the ST63(8). The recombinant clone ST6521(11A) (variant of ST156(9V)) increased in frequency. The decrease of serotype 19A IPD was linked to a fall in those antibiotic susceptible clones. In the last period, rates of penicillin-and cefotaxime-resistance remained under 10% and 4%, respectively. Adult IPD decreased after the PCV13 introduction in Spain due to herd protection. The spread of multidrug resistant clones (ST386(6C), ST6521(11A)) related to non-PCV13 serotypes needs further surveillance.Public Library of Science (PLoS)2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/130801Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0175224PLoS One, 2017, vol. 12, num. 4, p. e0175224https://doi.org/10.1371/journal.pone.0175224cc-by (c) Càmara, Jordi et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1308012026-05-29T05:05:01Z
dc.title.none.fl_str_mv Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
title Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
spellingShingle Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
Càmara Mas, Jordi
Pneumònia
Vacunes
Espanya
Infeccions per pneumococs
Pneumonia
Vaccines
Spain
Pneumococcal Infections
title_short Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
title_full Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
title_fullStr Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
title_full_unstemmed Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
title_sort Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain
dc.creator.none.fl_str_mv Càmara Mas, Jordi
Marimón, José María
Cercenado, Emilia
Larrosa, Nieves
Quesada, María Dolores
Fontanals, Dionísia
Cubero, Meritxell
Pérez Trallero, Emilio
Fenoll, Asunción
Liñares Louzao, Josefina
Ardanuy Tisaire, María Carmen
author Càmara Mas, Jordi
author_facet Càmara Mas, Jordi
Marimón, José María
Cercenado, Emilia
Larrosa, Nieves
Quesada, María Dolores
Fontanals, Dionísia
Cubero, Meritxell
Pérez Trallero, Emilio
Fenoll, Asunción
Liñares Louzao, Josefina
Ardanuy Tisaire, María Carmen
author_role author
author2 Marimón, José María
Cercenado, Emilia
Larrosa, Nieves
Quesada, María Dolores
Fontanals, Dionísia
Cubero, Meritxell
Pérez Trallero, Emilio
Fenoll, Asunción
Liñares Louzao, Josefina
Ardanuy Tisaire, María Carmen
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumònia
Vacunes
Espanya
Infeccions per pneumococs
Pneumonia
Vaccines
Spain
Pneumococcal Infections
topic Pneumònia
Vacunes
Espanya
Infeccions per pneumococs
Pneumonia
Vaccines
Spain
Pneumococcal Infections
description A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV13 introduction for children on adult IPD. A total of 1558 IPD episodes were detected. The incidence of IPD decreased significantly in the second period by-33.9% (95% CI,-40.3% to-26.8%). IPD due to PCV7 serotypes (-52.7%; 95% CI,-64.2% to-37.5%) and to PCV13 additional serotypes (-55.0% 95% CI, -62.0% to-46.7%) significantly decreased whereas IPD due to non-PCV13 serotypes remained stable (1.0% 95% CI,-12.9% to 17.2%). IPD due to all PCV13 additional serotypes significantly declined with the exception of serotype 3 (-11.3%; 95% CI-35.0% to 21.1%). IPD due to two non-PCV13 serotypes varied: serotype 6C that rose (301.6%; 95% CI, 92.7% to 733.3%, p<0.001), related to the expansion of ST386(6C), and serotype 8 that decreased (-34.9%, 95% CI,-57.1 to-1.2, p = 0.049), related to a decline of the ST63(8). The recombinant clone ST6521(11A) (variant of ST156(9V)) increased in frequency. The decrease of serotype 19A IPD was linked to a fall in those antibiotic susceptible clones. In the last period, rates of penicillin-and cefotaxime-resistance remained under 10% and 4%, respectively. Adult IPD decreased after the PCV13 introduction in Spain due to herd protection. The spread of multidrug resistant clones (ST386(6C), ST6521(11A)) related to non-PCV13 serotypes needs further surveillance.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130801
url https://hdl.handle.net/2445/130801
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0175224
PLoS One, 2017, vol. 12, num. 4, p. e0175224
https://doi.org/10.1371/journal.pone.0175224
dc.rights.none.fl_str_mv cc-by (c) Càmara, Jordi et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Càmara, Jordi et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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