Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity

Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive...

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Detalles Bibliográficos
Autores: Tejero, Jesús, Jimenez López, Pilar, Quinto, Emiliano, Córdoba Díaz, Damián, Garrosa, Manuel, Córdoba Díaz, Manuel, Gayoso, Manuel, Girbés Juan, Tomás
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/23896
Acceso en línea:https://hdl.handle.net/20.500.14352/23896
Access Level:acceso abierto
Palabra clave:615.4
Sambucus ebulus L.
Sambucus nigra L.
ebulin
nigrin
immunotoxins
nigrin b mode
Farmacología (Farmacia)
Tecnología farmaceútica
3209 Farmacología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/23896
network_acronym_str ES
network_name_str España
repository_id_str
spelling Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin ActivityTejero, JesúsJimenez López, PilarQuinto, EmilianoCórdoba Díaz, DamiánGarrosa, ManuelCórdoba Díaz, ManuelGayoso, ManuelGirbés Juan, Tomás615.4Sambucus ebulus L.Sambucus nigra L.ebulinnigrinimmunotoxinsnigrin b modeFarmacología (Farmacia)Tecnología farmaceútica3209 FarmacologíaSambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses.MDPIUniversidad Complutense de Madrid20152015-01-3020152015-01-30journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/23896reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 3.0 Españahttps://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/238962026-06-02T12:44:21Z
dc.title.none.fl_str_mv Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
title Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
spellingShingle Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
Tejero, Jesús
615.4
Sambucus ebulus L.
Sambucus nigra L.
ebulin
nigrin
immunotoxins
nigrin b mode
Farmacología (Farmacia)
Tecnología farmaceútica
3209 Farmacología
title_short Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
title_full Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
title_fullStr Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
title_full_unstemmed Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
title_sort Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity
dc.creator.none.fl_str_mv Tejero, Jesús
Jimenez López, Pilar
Quinto, Emiliano
Córdoba Díaz, Damián
Garrosa, Manuel
Córdoba Díaz, Manuel
Gayoso, Manuel
Girbés Juan, Tomás
author Tejero, Jesús
author_facet Tejero, Jesús
Jimenez López, Pilar
Quinto, Emiliano
Córdoba Díaz, Damián
Garrosa, Manuel
Córdoba Díaz, Manuel
Gayoso, Manuel
Girbés Juan, Tomás
author_role author
author2 Jimenez López, Pilar
Quinto, Emiliano
Córdoba Díaz, Damián
Garrosa, Manuel
Córdoba Díaz, Manuel
Gayoso, Manuel
Girbés Juan, Tomás
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.4
Sambucus ebulus L.
Sambucus nigra L.
ebulin
nigrin
immunotoxins
nigrin b mode
Farmacología (Farmacia)
Tecnología farmaceútica
3209 Farmacología
topic 615.4
Sambucus ebulus L.
Sambucus nigra L.
ebulin
nigrin
immunotoxins
nigrin b mode
Farmacología (Farmacia)
Tecnología farmaceútica
3209 Farmacología
description Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-30
2015
2015-01-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/23896
url https://hdl.handle.net/20.500.14352/23896
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 3.0 España
https://creativecommons.org/licenses/by-nc/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 3.0 España
https://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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