Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron ( B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what...

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Autores: Skwierawska, Dominika, López Valverde, José Antonio, Balcerzyk, Marcin, Leal, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/280266
Acceso en línea:http://hdl.handle.net/10261/280266
Access Level:acceso abierto
Palabra clave:BNCT
Targeted therapy
Biological dosimetry
Boron imaging
Personalized oncology
Personalized medicine
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spelling Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation TreatmentSkwierawska, DominikaLópez Valverde, José AntonioBalcerzyk, MarcinLeal, AntonioBNCTTargeted therapyBiological dosimetryBoron imagingPersonalized oncologyPersonalized medicineBoron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron ( B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.Grant RTI2018-098656-B-100 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union”. The APC was also funded by this research project. This research was also possible thanks to Project P20_01053 funded by the European Union and the Junta de Andalucía through the European Regional Development Fund (FEDER); D.S. received funding from ERASMUS PLUS-European Commission program for 2014–2020, project number 2019-1-PL01-KA103-062953; J.A.L.V. received funding from the FPU call from the Spanish Ministry of Science, Innovation, and Universities, reference number FPU19/02950.Multidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)European CommissionJunta de AndalucíaMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/280266reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//RTI2018-098656-B-100http://doi.org/10.3390/cancers14122865Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2802662026-05-22T06:33:51Z
dc.title.none.fl_str_mv Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
title Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
spellingShingle Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
Skwierawska, Dominika
BNCT
Targeted therapy
Biological dosimetry
Boron imaging
Personalized oncology
Personalized medicine
title_short Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
title_full Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
title_fullStr Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
title_full_unstemmed Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
title_sort Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
dc.creator.none.fl_str_mv Skwierawska, Dominika
López Valverde, José Antonio
Balcerzyk, Marcin
Leal, Antonio
author Skwierawska, Dominika
author_facet Skwierawska, Dominika
López Valverde, José Antonio
Balcerzyk, Marcin
Leal, Antonio
author_role author
author2 López Valverde, José Antonio
Balcerzyk, Marcin
Leal, Antonio
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
European Commission
Junta de Andalucía
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv BNCT
Targeted therapy
Biological dosimetry
Boron imaging
Personalized oncology
Personalized medicine
topic BNCT
Targeted therapy
Biological dosimetry
Boron imaging
Personalized oncology
Personalized medicine
description Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron ( B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/280266
url http://hdl.handle.net/10261/280266
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//RTI2018-098656-B-100
http://doi.org/10.3390/cancers14122865
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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