Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD

This study explored the use of parasternal second intercostal space and lower intercostal space surface electromyogram (sEMG) and surface mechanomyogram (sMMG) recordings (sEMGpara and sMMGpara, and sEMGlic and sMMGlic, respectively) to assess neural respiratory drive (NRD), neuromechanical (NMC) an...

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Autores: Lozano García, Manuel, Estrada Petrocelli, Luis, Blanco Almazan, Dolores, Tas, Basak, Cho, Peter S. P., Moxham, John, Rafferty, Gerrard, Torres, Abel, Jane, Raimon, Jolley, C. J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/186553
Acceso en línea:https://hdl.handle.net/2445/186553
Access Level:acceso abierto
Palabra clave:Malalties pulmonars obstructives cròniques
Respiració artificial
Chronic obstructive pulmonary diseases
Artificial respiration
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spelling Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPDLozano García, ManuelEstrada Petrocelli, LuisBlanco Almazan, DoloresTas, BasakCho, Peter S. P.Moxham, JohnRafferty, GerrardTorres, AbelJane, RaimonJolley, C. J.Malalties pulmonars obstructives cròniquesRespiració artificialChronic obstructive pulmonary diseasesArtificial respirationThis study explored the use of parasternal second intercostal space and lower intercostal space surface electromyogram (sEMG) and surface mechanomyogram (sMMG) recordings (sEMGpara and sMMGpara, and sEMGlic and sMMGlic, respectively) to assess neural respiratory drive (NRD), neuromechanical (NMC) and neuroventilatory (NVC) coupling, and mechanical efficiency (MEff) noninvasively in healthy subjects and chronic obstructive pulmonary disease (COPD) patients. sEMGpara, sMMGpara, sEMGlic, sMMGlic, mouth pressure (Pmo), and volume (Vi) were measured at rest, and during an inspiratory loading protocol, in 16 COPD patients (8 moderate and 8 severe) and 9 healthy subjects. Myographic signals were analyzed using fixed sample entropy and normalized to their largest values (fSEsEMGpara%max, fSEsMMGpara%max, fSEsEMGlic%max, and fSEsMMGlic%max). fSEsMMGpara%max, fSEsEMGpara%max, and fSEsEMGlic%max were significantly higher in COPD than in healthy participants at rest. Parasternal intercostal muscle NMC was significantly higher in healthy than in COPD participants at rest, but not during threshold loading. Pmo-derived NMC and MEff ratios were lower in severe patients than in mild patients or healthy subjects during threshold loading, but differences were not consistently significant. During resting breathing and threshold loading, Vi-derived NVC and MEff ratios were significantly lower in severe patients than in mild patients or healthy subjects. sMMG is a potential noninvasive alternative to sEMG for assessing NRD in COPD. The ratios of Pmo and Vi to sMMG and sEMG measurements provide wholly noninvasive NMC, NVC, and MEff indices that are sensitive to impaired respiratory mechanics in COPD and are therefore of potential value to assess disease severity in clinical practice. AuthorIEEE2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/186553Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1109/JBHI.2022.3166255IEEE Journal Of Biomedical And Health Informatics, 2022https://doi.org/10.1109/JBHI.2022.3166255cc by-nc-nd (c) Lozano García, Manuel et al, 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1865532025-07-25T16:43:42Z
dc.title.none.fl_str_mv Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
title Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
spellingShingle Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
Lozano García, Manuel
Malalties pulmonars obstructives cròniques
Respiració artificial
Chronic obstructive pulmonary diseases
Artificial respiration
title_short Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
title_full Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
title_fullStr Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
title_full_unstemmed Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
title_sort Noninvasive Assessment of Neuromechanical and Neuroventilatory Coupling in COPD
dc.creator.none.fl_str_mv Lozano García, Manuel
Estrada Petrocelli, Luis
Blanco Almazan, Dolores
Tas, Basak
Cho, Peter S. P.
Moxham, John
Rafferty, Gerrard
Torres, Abel
Jane, Raimon
Jolley, C. J.
author Lozano García, Manuel
author_facet Lozano García, Manuel
Estrada Petrocelli, Luis
Blanco Almazan, Dolores
Tas, Basak
Cho, Peter S. P.
Moxham, John
Rafferty, Gerrard
Torres, Abel
Jane, Raimon
Jolley, C. J.
author_role author
author2 Estrada Petrocelli, Luis
Blanco Almazan, Dolores
Tas, Basak
Cho, Peter S. P.
Moxham, John
Rafferty, Gerrard
Torres, Abel
Jane, Raimon
Jolley, C. J.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties pulmonars obstructives cròniques
Respiració artificial
Chronic obstructive pulmonary diseases
Artificial respiration
topic Malalties pulmonars obstructives cròniques
Respiració artificial
Chronic obstructive pulmonary diseases
Artificial respiration
description This study explored the use of parasternal second intercostal space and lower intercostal space surface electromyogram (sEMG) and surface mechanomyogram (sMMG) recordings (sEMGpara and sMMGpara, and sEMGlic and sMMGlic, respectively) to assess neural respiratory drive (NRD), neuromechanical (NMC) and neuroventilatory (NVC) coupling, and mechanical efficiency (MEff) noninvasively in healthy subjects and chronic obstructive pulmonary disease (COPD) patients. sEMGpara, sMMGpara, sEMGlic, sMMGlic, mouth pressure (Pmo), and volume (Vi) were measured at rest, and during an inspiratory loading protocol, in 16 COPD patients (8 moderate and 8 severe) and 9 healthy subjects. Myographic signals were analyzed using fixed sample entropy and normalized to their largest values (fSEsEMGpara%max, fSEsMMGpara%max, fSEsEMGlic%max, and fSEsMMGlic%max). fSEsMMGpara%max, fSEsEMGpara%max, and fSEsEMGlic%max were significantly higher in COPD than in healthy participants at rest. Parasternal intercostal muscle NMC was significantly higher in healthy than in COPD participants at rest, but not during threshold loading. Pmo-derived NMC and MEff ratios were lower in severe patients than in mild patients or healthy subjects during threshold loading, but differences were not consistently significant. During resting breathing and threshold loading, Vi-derived NVC and MEff ratios were significantly lower in severe patients than in mild patients or healthy subjects. sMMG is a potential noninvasive alternative to sEMG for assessing NRD in COPD. The ratios of Pmo and Vi to sMMG and sEMG measurements provide wholly noninvasive NMC, NVC, and MEff indices that are sensitive to impaired respiratory mechanics in COPD and are therefore of potential value to assess disease severity in clinical practice. Author
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186553
url https://hdl.handle.net/2445/186553
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1109/JBHI.2022.3166255
IEEE Journal Of Biomedical And Health Informatics, 2022
https://doi.org/10.1109/JBHI.2022.3166255
dc.rights.none.fl_str_mv cc by-nc-nd (c) Lozano García, Manuel et al, 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Lozano García, Manuel et al, 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IEEE
publisher.none.fl_str_mv IEEE
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,638193

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