Optical coherence tomography to monitor photodynamic therapy in pathological myopia

To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularisation (CNV) activity before and after photodynamic therapy (PDT) in patients with pathological myopia. METHODS: 33 patients (33 eyes) with pathological myopia and being treated with PDT were included. Ev...

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Autores: Garcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836, Salinas-Alaman, A. (Ángel)|||/items/ac6c3088-aae2-4d82-97b0-d087742c1901, Maldonado, M.J. (Miguel J.)|||/items/8981033c-451a-4709-9f05-52319f509a9d, Sainz-Gomez, C. (C.)|||/items/ceeb0a23-78f6-406f-82b7-57b1b8d901e5, Fernandez-Hortelano, A. (A.)|||/items/7ea9d8f5-d845-4190-8e5f-17072f1e233f
Tipo de recurso: artículo
Fecha de publicación:2006
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/22664
Acceso en línea:https://hdl.handle.net/10171/22664
Access Level:acceso abierto
Palabra clave:Choroid/pathology
Choroidal Neovascularization/drug therapy/pathology
Extracellular Fluid
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spelling Optical coherence tomography to monitor photodynamic therapy in pathological myopiaGarcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836Salinas-Alaman, A. (Ángel)|||/items/ac6c3088-aae2-4d82-97b0-d087742c1901Maldonado, M.J. (Miguel J.)|||/items/8981033c-451a-4709-9f05-52319f509a9dSainz-Gomez, C. (C.)|||/items/ceeb0a23-78f6-406f-82b7-57b1b8d901e5Fernandez-Hortelano, A. (A.)|||/items/7ea9d8f5-d845-4190-8e5f-17072f1e233fChoroid/pathologyChoroidal Neovascularization/drug therapy/pathologyExtracellular FluidTo evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularisation (CNV) activity before and after photodynamic therapy (PDT) in patients with pathological myopia. METHODS: 33 patients (33 eyes) with pathological myopia and being treated with PDT were included. Every 3 months all patients were evaluated and presence or absence of leakage on fluorescein angiography, presence of intraretinal or subretinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT, were determined at each examination. RESULTS: The macular thickness decreased significantly after PDT at 6 months (p = 0.001) and at 12 months follow up (p = 0.01). However, no significant changes in CNV thickness were measured after PDT at 6 months of follow up (p = 0.418) and at 12 months of follow up (p = 0.521). Once the diagnosis of CNV associated with pathological myopia was established, before treatment, OCT had a sensitivity of 96.96% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.23%) and a moderate specificity (69,69%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 79.62%. CONCLUSIONS: OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with pathological myopia.Oxford University PressDadun. Depósito Académico Digital Universidad de Navarra20122012-06-2020062006-01-0120062006-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/22664reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/226642026-06-21T12:47:57Z
dc.title.none.fl_str_mv Optical coherence tomography to monitor photodynamic therapy in pathological myopia
title Optical coherence tomography to monitor photodynamic therapy in pathological myopia
spellingShingle Optical coherence tomography to monitor photodynamic therapy in pathological myopia
Garcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836
Choroid/pathology
Choroidal Neovascularization/drug therapy/pathology
Extracellular Fluid
title_short Optical coherence tomography to monitor photodynamic therapy in pathological myopia
title_full Optical coherence tomography to monitor photodynamic therapy in pathological myopia
title_fullStr Optical coherence tomography to monitor photodynamic therapy in pathological myopia
title_full_unstemmed Optical coherence tomography to monitor photodynamic therapy in pathological myopia
title_sort Optical coherence tomography to monitor photodynamic therapy in pathological myopia
dc.creator.none.fl_str_mv Garcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836
Salinas-Alaman, A. (Ángel)|||/items/ac6c3088-aae2-4d82-97b0-d087742c1901
Maldonado, M.J. (Miguel J.)|||/items/8981033c-451a-4709-9f05-52319f509a9d
Sainz-Gomez, C. (C.)|||/items/ceeb0a23-78f6-406f-82b7-57b1b8d901e5
Fernandez-Hortelano, A. (A.)|||/items/7ea9d8f5-d845-4190-8e5f-17072f1e233f
author Garcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836
author_facet Garcia-Layana, A. (Alfredo)|||/items/631fff44-be4e-42e5-ad3a-8f0f10305836
Salinas-Alaman, A. (Ángel)|||/items/ac6c3088-aae2-4d82-97b0-d087742c1901
Maldonado, M.J. (Miguel J.)|||/items/8981033c-451a-4709-9f05-52319f509a9d
Sainz-Gomez, C. (C.)|||/items/ceeb0a23-78f6-406f-82b7-57b1b8d901e5
Fernandez-Hortelano, A. (A.)|||/items/7ea9d8f5-d845-4190-8e5f-17072f1e233f
author_role author
author2 Salinas-Alaman, A. (Ángel)|||/items/ac6c3088-aae2-4d82-97b0-d087742c1901
Maldonado, M.J. (Miguel J.)|||/items/8981033c-451a-4709-9f05-52319f509a9d
Sainz-Gomez, C. (C.)|||/items/ceeb0a23-78f6-406f-82b7-57b1b8d901e5
Fernandez-Hortelano, A. (A.)|||/items/7ea9d8f5-d845-4190-8e5f-17072f1e233f
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Choroid/pathology
Choroidal Neovascularization/drug therapy/pathology
Extracellular Fluid
topic Choroid/pathology
Choroidal Neovascularization/drug therapy/pathology
Extracellular Fluid
description To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularisation (CNV) activity before and after photodynamic therapy (PDT) in patients with pathological myopia. METHODS: 33 patients (33 eyes) with pathological myopia and being treated with PDT were included. Every 3 months all patients were evaluated and presence or absence of leakage on fluorescein angiography, presence of intraretinal or subretinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT, were determined at each examination. RESULTS: The macular thickness decreased significantly after PDT at 6 months (p = 0.001) and at 12 months follow up (p = 0.01). However, no significant changes in CNV thickness were measured after PDT at 6 months of follow up (p = 0.418) and at 12 months of follow up (p = 0.521). Once the diagnosis of CNV associated with pathological myopia was established, before treatment, OCT had a sensitivity of 96.96% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.23%) and a moderate specificity (69,69%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 79.62%. CONCLUSIONS: OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with pathological myopia.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01
2006
2006-01-01
2012
2012-06-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/22664
url https://hdl.handle.net/10171/22664
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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