New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India

22 páginas, 8 figuras.

Detalles Bibliográficos
Autores: Warrell, David A., Gutiérrez, José María, Calvete, Juan J., Williams, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/94985
Acceso en línea:http://hdl.handle.net/10261/94985
Access Level:acceso abierto
Palabra clave:Antivenoms
Cobra
Envenoming
krait
Preclinical efficacy
Russell’s viper
Snakebite
Venom
Venomics
id ES_a6e09608279c9b9285bcd1085b3db33d
oai_identifier_str oai:digital.csic.es:10261/94985
network_acronym_str ES
network_name_str España
repository_id_str
spelling New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in IndiaWarrell, David A.Gutiérrez, José MaríaCalvete, Juan J.Williams, DavidAntivenomsCobraEnvenomingkraitPreclinical efficacyRussell’s viperSnakebiteVenomVenomics22 páginas, 8 figuras.The direct estimate of 46,000 snakebite deaths in India in 2005 (1 for every 2 HIV/AIDS deaths), based on verbal autopsies, renders unrealistic the total of only 47,000 snakebite deaths in the whole world in 2010, obtained indirectly as part of the "Global Burden of Disease 2010" study. Persistent underestimation of its true morbidity and mortality has made snakebite the most neglected of all the WHO's "neglected tropical diseases", downgrading its public health importance. Strategies to address this neglect should include the improvement of antivenom, the only specific antidote to envenoming. To accommodate increased understanding of geographical intraspecific variation in venom composition and the range of snake species that are medically important in India, the design of antivenoms (choice of venom sources and species coverage) should be reconsidered. Methods of preclinical and clinical testing should be improved. The relatively new science of venomics involves techniques and strategies for assessing the toxin composition of snake venoms directly through proteomics-centred approaches or indirectly via high-throughput venom gland transcriptomics and bioinformatic analysis. Antivenomics is translational venomics: a proteomics-based protocol to quantify the extent of cross-reactivity of antivenoms against homologous and heterologous venoms. These approaches could revolutionize the preclinical assessment of antivenom efficacy, leading to a new generation of antivenoms that are clinically more effectiveFunding for the projects (to JJC) was provided by grant BFU2007-61563 and BFU2010-17373 from the Ministerios de Educación y Ciencia and Ciencia é Innovación, Madrid; CRUSACSIC (2007CR0004 and 2009CR0021); and CYTED (206AC0281). Travelling between Spain and Costa Rica was financed by Acciones Integradas 2006CR0010 between CSIC and the University of Costa Rica (UCR).Peer reviewedIndian Council of Medical Research201420142013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/94985reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.ijmr.org.in/text.asp?2013/138/1/38/116180info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/949852026-05-22T06:33:51Z
dc.title.none.fl_str_mv New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
title New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
spellingShingle New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
Warrell, David A.
Antivenoms
Cobra
Envenoming
krait
Preclinical efficacy
Russell’s viper
Snakebite
Venom
Venomics
title_short New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
title_full New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
title_fullStr New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
title_full_unstemmed New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
title_sort New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India
dc.creator.none.fl_str_mv Warrell, David A.
Gutiérrez, José María
Calvete, Juan J.
Williams, David
author Warrell, David A.
author_facet Warrell, David A.
Gutiérrez, José María
Calvete, Juan J.
Williams, David
author_role author
author2 Gutiérrez, José María
Calvete, Juan J.
Williams, David
author2_role author
author
author
dc.subject.none.fl_str_mv Antivenoms
Cobra
Envenoming
krait
Preclinical efficacy
Russell’s viper
Snakebite
Venom
Venomics
topic Antivenoms
Cobra
Envenoming
krait
Preclinical efficacy
Russell’s viper
Snakebite
Venom
Venomics
description 22 páginas, 8 figuras.
publishDate 2013
dc.date.none.fl_str_mv 2013
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/94985
url http://hdl.handle.net/10261/94985
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.ijmr.org.in/text.asp?2013/138/1/38/116180
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Indian Council of Medical Research
publisher.none.fl_str_mv Indian Council of Medical Research
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415733391261696
score 15.81155

Similares en LA Referencia