Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets

In spite of widespread insecticide resistance in vector mosquitoes throughout Africa, there is limited evidence that long-lasting insecticidal bed nets (LLINs) are failing to protect against malaria. Here, we showed that LLIN contact in the course of host-seeking resulted in higher mortality of resi...

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Autores: Glunt, Katey D., Coetzee, Maureen, Huijben, Silvie, Koffi, A. Alphonsine, Lynch, Penelope A., N'Guessan, Raphael, Oumbouke, Welbeck A., Sternberg, Eleanore D., Thomas, Matthew B.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/122195
Acceso en línea:https://hdl.handle.net/2445/122195
Access Level:acceso abierto
Palabra clave:Anopheles
Malària
Malaria
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spelling Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed netsGlunt, Katey D.Coetzee, MaureenHuijben, SilvieKoffi, A. AlphonsineLynch, Penelope A.N'Guessan, RaphaelOumbouke, Welbeck A.Sternberg, Eleanore D.Thomas, Matthew B.AnophelesMalàriaAnophelesMalariaIn spite of widespread insecticide resistance in vector mosquitoes throughout Africa, there is limited evidence that long-lasting insecticidal bed nets (LLINs) are failing to protect against malaria. Here, we showed that LLIN contact in the course of host-seeking resulted in higher mortality of resistant Anopheles spp. mosquitoes than predicted from standard laboratory exposures with the same net. We also found that sublethal contact with an LLIN caused a reduction in blood feeding and subsequent host-seeking success in multiple lines of resistant mosquitoes from the laboratory and the field. Using a transmission model, we showed that when these LLIN-related lethal and sublethal effects were accrued over mosquito lifetimes, they greatly reduced the impact of resistance on malaria transmission potential under conditions of high net coverage. If coverage falls, the epidemiological impact is far more pronounced. Similarly, if the intensity of resistance intensifies, the loss of malaria control increases nonlinearly. Our findings help explain why insecticide resistance has not yet led to wide-scale failure of LLINs, but reinforce the call for alternative control tools and informed resistance management strategies.Wiley2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/122195Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1111/eva.12574Evolutionary Applications, 2018, vol. 11, num. 4, p. 431-441http://dx.doi.org/10.1111/eva.12574cc by (c) Glunt et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1221952026-05-27T06:46:51Z
dc.title.none.fl_str_mv Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
title Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
spellingShingle Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
Glunt, Katey D.
Anopheles
Malària
Anopheles
Malaria
title_short Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
title_full Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
title_fullStr Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
title_full_unstemmed Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
title_sort Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets
dc.creator.none.fl_str_mv Glunt, Katey D.
Coetzee, Maureen
Huijben, Silvie
Koffi, A. Alphonsine
Lynch, Penelope A.
N'Guessan, Raphael
Oumbouke, Welbeck A.
Sternberg, Eleanore D.
Thomas, Matthew B.
author Glunt, Katey D.
author_facet Glunt, Katey D.
Coetzee, Maureen
Huijben, Silvie
Koffi, A. Alphonsine
Lynch, Penelope A.
N'Guessan, Raphael
Oumbouke, Welbeck A.
Sternberg, Eleanore D.
Thomas, Matthew B.
author_role author
author2 Coetzee, Maureen
Huijben, Silvie
Koffi, A. Alphonsine
Lynch, Penelope A.
N'Guessan, Raphael
Oumbouke, Welbeck A.
Sternberg, Eleanore D.
Thomas, Matthew B.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anopheles
Malària
Anopheles
Malaria
topic Anopheles
Malària
Anopheles
Malaria
description In spite of widespread insecticide resistance in vector mosquitoes throughout Africa, there is limited evidence that long-lasting insecticidal bed nets (LLINs) are failing to protect against malaria. Here, we showed that LLIN contact in the course of host-seeking resulted in higher mortality of resistant Anopheles spp. mosquitoes than predicted from standard laboratory exposures with the same net. We also found that sublethal contact with an LLIN caused a reduction in blood feeding and subsequent host-seeking success in multiple lines of resistant mosquitoes from the laboratory and the field. Using a transmission model, we showed that when these LLIN-related lethal and sublethal effects were accrued over mosquito lifetimes, they greatly reduced the impact of resistance on malaria transmission potential under conditions of high net coverage. If coverage falls, the epidemiological impact is far more pronounced. Similarly, if the intensity of resistance intensifies, the loss of malaria control increases nonlinearly. Our findings help explain why insecticide resistance has not yet led to wide-scale failure of LLINs, but reinforce the call for alternative control tools and informed resistance management strategies.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/122195
url https://hdl.handle.net/2445/122195
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1111/eva.12574
Evolutionary Applications, 2018, vol. 11, num. 4, p. 431-441
http://dx.doi.org/10.1111/eva.12574
dc.rights.none.fl_str_mv cc by (c) Glunt et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Glunt et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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