Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet

Chaysavanh Manichanh et al.

Detalles Bibliográficos
Autores: Manichanh, Chaysavanh, Roca, Joaquim, Azpiroz, Fernando
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/116969
Acceso en línea:http://hdl.handle.net/10261/116969
Access Level:acceso abierto
Palabra clave:Intestinal gas
Bloating
Diet
Dysbiosis
Microbial instability
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spelling Anal gas evacuation and colonic microbiota in patients with flatulence: effect of dietManichanh, ChaysavanhRoca, JoaquimAzpiroz, FernandoIntestinal gasBloatingDietDysbiosisMicrobial instabilityChaysavanh Manichanh et al.Objective: To characterise the influence of diet on abdominal symptoms, anal gas evacuation, intestinal gas distribution and colonic microbiota in patients complaining of flatulence. Design Patients complaining of flatulence (n=30) and healthy subjects (n=20) were instructed to follow their usual diet for 3 days (basal phase) and to consume a high-flatulogenic diet for another 3 days (challenge phase). Results: During basal phase, patients recorded more abdominal symptoms than healthy subjects in daily questionnaires (5.8±0.3 vs 0.4±0.2 mean discomfort/pain score, respectively; p=<0.0001) and more gas evacuations by an event marker (21.9±2.8 vs 7.4±1.0 daytime evacuations, respectively; p=0.0001), without differences in the volume of gas evacuated after a standard meal (262±22 and 265±25 mL, respectively). On flatulogenic diet, both groups recorded more abdominal symptoms (7.9±0.3 and 2.8±0.4 discomfort/pain, respectively), number of gas evacuations (44.4±5.3 and 21.7±2.9 daytime evacuations, respectively) and had more gas production (656±52 and 673±78 mL, respectively; p<0.05 vs basal diet for all). When challenged with flatulogenic diet, patients' microbiota developed instability in composition, exhibiting variations in the main phyla and reduction of microbial diversity, whereas healthy subjects¿ microbiota were stable. Taxa from Bacteroides fragilis or Bilophila wadsworthia correlated with number of gas evacuations or volume of gas evacuated, respectively. Conclusions Patients complaining of flatulence have a poor tolerance of intestinal gas, which is associated with instability of the microbial ecosystemThis work was supported by the FIS PI10/00902 grant (Ministerio de Ciencia e Innovacion, Spain), the Spanish Ministry of Education (Dirección General de Investigación, SAF 2009–07416), Fundació La Marató TV3 (MARATV3_072010), the European Community’s Seventh Framework Programme (FP7/2007–2013: IHMS, grant agreement HEALTH.2010.2.1.1-2) and a grant from Danone Research (France). Ciberehd is funded by the Instituto de Salud Carlos IIIPeer ReviewedBMJ Publishing Group2015201520142015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/116969reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/261376http://dx.doi.org/10.1136/gutjnl-2012-303013info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1169692026-05-22T06:33:51Z
dc.title.none.fl_str_mv Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
title Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
spellingShingle Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
Manichanh, Chaysavanh
Intestinal gas
Bloating
Diet
Dysbiosis
Microbial instability
title_short Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
title_full Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
title_fullStr Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
title_full_unstemmed Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
title_sort Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet
dc.creator.none.fl_str_mv Manichanh, Chaysavanh
Roca, Joaquim
Azpiroz, Fernando
author Manichanh, Chaysavanh
author_facet Manichanh, Chaysavanh
Roca, Joaquim
Azpiroz, Fernando
author_role author
author2 Roca, Joaquim
Azpiroz, Fernando
author2_role author
author
dc.subject.none.fl_str_mv Intestinal gas
Bloating
Diet
Dysbiosis
Microbial instability
topic Intestinal gas
Bloating
Diet
Dysbiosis
Microbial instability
description Chaysavanh Manichanh et al.
publishDate 2014
dc.date.none.fl_str_mv 2014
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/116969
url http://hdl.handle.net/10261/116969
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/261376
http://dx.doi.org/10.1136/gutjnl-2012-303013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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