Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors
Importance: Alcohol consumption is a leading cause of morbidity and mortality that may be more important in older adults with socioeconomic or health-related risk factors. Objective: To examine the association of alcohol consumption patterns with 12-year mortality and its modification by health-rela...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/25289 |
| Acceso en línea: | https://hdl.handle.net/20.500.12105/25289 |
| Access Level: | acceso abierto |
| Palabra clave: | Aged Alcohol Drinking Cause of Death Female Humans Male Middle Aged Mortality Prospective Studies Risk Factors Socioeconomic Factors United Kingdom |
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Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| title |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| spellingShingle |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors Ortolá, Rosario Aged Alcohol Drinking Cause of Death Female Humans Male Middle Aged Mortality Prospective Studies Risk Factors Socioeconomic Factors United Kingdom |
| title_short |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| title_full |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| title_fullStr |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| title_full_unstemmed |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| title_sort |
Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors |
| dc.creator.none.fl_str_mv |
Ortolá, Rosario Sotos-Prieto, Mercedes García-Esquinas, Esther Galan, Iñaki Rodríguez-Artalejo, Fernando |
| author |
Ortolá, Rosario |
| author_facet |
Ortolá, Rosario Sotos-Prieto, Mercedes García-Esquinas, Esther Galan, Iñaki Rodríguez-Artalejo, Fernando |
| author_role |
author |
| author2 |
Sotos-Prieto, Mercedes García-Esquinas, Esther Galan, Iñaki Rodríguez-Artalejo, Fernando |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Plan Nacional de Drogas (España) Ministerio de Sanidad (España) Instituto de Salud Carlos III Plan Nacional de I+D+i (España) Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) Agencia Estatal de Investigación (España) Unión Europea. Comisión Europea. NextGenerationEU Fundación Francisco Soria Melguizo Ministerio de Ciencia, Innovación y Universidades (España) |
| dc.subject.none.fl_str_mv |
Aged Alcohol Drinking Cause of Death Female Humans Male Middle Aged Mortality Prospective Studies Risk Factors Socioeconomic Factors United Kingdom |
| topic |
Aged Alcohol Drinking Cause of Death Female Humans Male Middle Aged Mortality Prospective Studies Risk Factors Socioeconomic Factors United Kingdom |
| description |
Importance: Alcohol consumption is a leading cause of morbidity and mortality that may be more important in older adults with socioeconomic or health-related risk factors. Objective: To examine the association of alcohol consumption patterns with 12-year mortality and its modification by health-related or socioeconomic risk factors. Design, setting, and participants: This prospective cohort study used data from the UK Biobank, a population-based cohort. Participants were current drinkers aged 60 years or older. Data were analyzed from September 2023 to May 2024. Exposure: According to their mean alcohol intake in grams per day, participants' drinking patterns were classified as occasional: ≤2.86 g/d), low risk (men: >2.86-20.00 g/d; women: >2.86-10.00 g/d), moderate risk (men: >20.00-40.00 g/d; women: >10.00-20.00 g/d) and high risk (men: >40.00 g/d; women: >20.00 g/d). Main outcomes and measures: Health-related risk factors were assessed with the frailty index, and socioeconomic risk factors were assessed with the Townsend deprivation index. All-cause and cause-specific mortality were obtained from death certificates held by the national registries. Analyses excluded deaths in the first 2 years of follow-up and adjusted for potential confounders, including drinking patterns and preferences. Results: A total of 135 103 participants (median [IQR] age, 64.0 [62.0-67.0] years; 67 693 [50.1%] women) were included. In the total analytical sample, compared with occasional drinking, high-risk drinking was associated with higher all-cause (hazard ratio [HR], 1.33; 95% CI, 1.24-1.42), cancer (HR, 1.39; 95% CI, 1.26-1.53), and cardiovascular (HR, 1.21; 95% CI, 1.04-1.41) mortality; moderate-risk drinking was associated with higher all-cause (HR, 1.10; 95% CI, 1.03-1.18) and cancer (HR, 1.15; 95% CI, 1.05-1.27) mortality, and low-risk drinking was associated with higher cancer mortality (HR, 1.11; 95% CI, 1.01-1.22). While no associations were found for low- or moderate-risk drinking patterns vs occasional drinking among individuals without socioeconomic or health-related risk factors, low-risk drinking was associated with higher cancer mortality (HR, 1.15; 95% CI, 1.01-1.30) and moderate-risk drinking with higher all-cause (HR, 1.10; 95% CI, 1.01-1.19) and cancer (HR, 1.19; 95% CI, 1.05-1.35) mortality among those with health-related risk factors; low-risk and moderate-risk drinking patterns were associated with higher mortality from all causes (low risk: HR, 1.14; 95% CI, 1.01-1.28; moderate risk: HR, 1.17; 95% CI, 1.03-1.32) and cancer (low risk: HR, 1.25; 95% CI, 1.04-1.50; moderate risk: HR, 1.36; 95% CI, 1.13-1.63) among those with socioeconomic risk factors. Wine preference (>80% of alcohol from wine) and drinking with meals showed small protective associations with mortality, especially from cancer, but only in drinkers with socioeconomic or health-related risk factors and was associated with attenuating the excess mortality associated with high-, moderate- and even low-risk drinking. Conclusions and relevance: In this cohort study of older drinkers from the UK, even low-risk drinking was associated with higher mortality among older adults with health-related or socioeconomic risk factors. The attenuation of mortality observed for wine preference and drinking only during meals requires further investigation, as it may mostly reflect the effect of healthier lifestyles, slower alcohol absorption, or nonalcoholic components of beverages. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-10-24 2024 2024-08-01 2024 2024-08-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/20.500.12105/25289 |
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https://hdl.handle.net/20.500.12105/25289 |
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Inglés eng |
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Inglés |
| language |
eng |
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ES PI2020 17 ES PI19 319 ES PI20 896 ES PI22 1111 ES CNS2022-135623 Not available Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII) PMP21%2F00093 METABOLOMICA, GENOMICA Y NUTRICIÓN PARA LA MEDICINA PERSONALIZADA DE ENFERMEDAD CARDIOVASCULAR (OMIC-CARD) ES RYC-2018-025069-I Not available |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk FactorsOrtolá, RosarioSotos-Prieto, MercedesGarcía-Esquinas, EstherGalan, IñakiRodríguez-Artalejo, FernandoAgedAlcohol DrinkingCause of DeathFemaleHumansMaleMiddle AgedMortalityProspective StudiesRisk FactorsSocioeconomic FactorsUnited KingdomImportance: Alcohol consumption is a leading cause of morbidity and mortality that may be more important in older adults with socioeconomic or health-related risk factors. Objective: To examine the association of alcohol consumption patterns with 12-year mortality and its modification by health-related or socioeconomic risk factors. Design, setting, and participants: This prospective cohort study used data from the UK Biobank, a population-based cohort. Participants were current drinkers aged 60 years or older. Data were analyzed from September 2023 to May 2024. Exposure: According to their mean alcohol intake in grams per day, participants' drinking patterns were classified as occasional: ≤2.86 g/d), low risk (men: >2.86-20.00 g/d; women: >2.86-10.00 g/d), moderate risk (men: >20.00-40.00 g/d; women: >10.00-20.00 g/d) and high risk (men: >40.00 g/d; women: >20.00 g/d). Main outcomes and measures: Health-related risk factors were assessed with the frailty index, and socioeconomic risk factors were assessed with the Townsend deprivation index. All-cause and cause-specific mortality were obtained from death certificates held by the national registries. Analyses excluded deaths in the first 2 years of follow-up and adjusted for potential confounders, including drinking patterns and preferences. Results: A total of 135 103 participants (median [IQR] age, 64.0 [62.0-67.0] years; 67 693 [50.1%] women) were included. In the total analytical sample, compared with occasional drinking, high-risk drinking was associated with higher all-cause (hazard ratio [HR], 1.33; 95% CI, 1.24-1.42), cancer (HR, 1.39; 95% CI, 1.26-1.53), and cardiovascular (HR, 1.21; 95% CI, 1.04-1.41) mortality; moderate-risk drinking was associated with higher all-cause (HR, 1.10; 95% CI, 1.03-1.18) and cancer (HR, 1.15; 95% CI, 1.05-1.27) mortality, and low-risk drinking was associated with higher cancer mortality (HR, 1.11; 95% CI, 1.01-1.22). While no associations were found for low- or moderate-risk drinking patterns vs occasional drinking among individuals without socioeconomic or health-related risk factors, low-risk drinking was associated with higher cancer mortality (HR, 1.15; 95% CI, 1.01-1.30) and moderate-risk drinking with higher all-cause (HR, 1.10; 95% CI, 1.01-1.19) and cancer (HR, 1.19; 95% CI, 1.05-1.35) mortality among those with health-related risk factors; low-risk and moderate-risk drinking patterns were associated with higher mortality from all causes (low risk: HR, 1.14; 95% CI, 1.01-1.28; moderate risk: HR, 1.17; 95% CI, 1.03-1.32) and cancer (low risk: HR, 1.25; 95% CI, 1.04-1.50; moderate risk: HR, 1.36; 95% CI, 1.13-1.63) among those with socioeconomic risk factors. Wine preference (>80% of alcohol from wine) and drinking with meals showed small protective associations with mortality, especially from cancer, but only in drinkers with socioeconomic or health-related risk factors and was associated with attenuating the excess mortality associated with high-, moderate- and even low-risk drinking. Conclusions and relevance: In this cohort study of older drinkers from the UK, even low-risk drinking was associated with higher mortality among older adults with health-related or socioeconomic risk factors. The attenuation of mortality observed for wine preference and drinking only during meals requires further investigation, as it may mostly reflect the effect of healthier lifestyles, slower alcohol absorption, or nonalcoholic components of beverages.ElsevierPlan Nacional de Drogas (España)Ministerio de Sanidad (España)Instituto de Salud Carlos IIIPlan Nacional de I+D+i (España)Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Agencia Estatal de Investigación (España)Unión Europea. Comisión Europea. NextGenerationEUFundación Francisco Soria MelguizoMinisterio de Ciencia, Innovación y Universidades (España)20242024-10-2420242024-08-0120242024-08-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.12105/25289reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI2020 17ES PI19 319ES PI20 896ES PI22 1111ES CNS2022-135623 Not availableInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII) PMP21%2F00093 METABOLOMICA, GENOMICA Y NUTRICIÓN PARA LA MEDICINA PERSONALIZADA DE ENFERMEDAD CARDIOVASCULAR (OMIC-CARD)ES RYC-2018-025069-I Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/252892026-06-12T12:43:37Z |
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