Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses

Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, w...

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Detalles Bibliográficos
Autores: Lagunas, Anna, Martínez Fraiz, Elena, Samitier i Martí, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/121073
Acceso en línea:https://hdl.handle.net/2445/121073
Access Level:acceso abierto
Palabra clave:Diferenciació cel·lular
Morfologia (Biologia)
Cell diferentiation
Morphology (Biology)
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spelling Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell ResponsesLagunas, AnnaMartínez Fraiz, ElenaSamitier i Martí, JosepDiferenciació cel·lularMorfologia (Biologia)Cell diferentiationMorphology (Biology)Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, we review some of the most recent examples in which gradients have been used to evaluate the effect of a varying ligand concentration in cell adhesion, morphology, growth, and differentiation of cells, including some of our recent findings. They show the importance of the organization of ligands at the nanoscale, which is highlighted by abrupt changes in cell behavior at critical concentration thresholds.Frontiers Media2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/121073Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fbioe.2015.00132Frontiers in Bioengineering and Biotechnology, 2015, vol. 3, num. 132https://doi.org/10.3389/fbioe.2015.00132info:eu-repo/grantAgreement/EC/H2020/634928cc-by (c) Lagunas, Anna et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1210732026-05-29T05:05:01Z
dc.title.none.fl_str_mv Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
title Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
spellingShingle Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
Lagunas, Anna
Diferenciació cel·lular
Morfologia (Biologia)
Cell diferentiation
Morphology (Biology)
title_short Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
title_full Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
title_fullStr Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
title_full_unstemmed Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
title_sort Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
dc.creator.none.fl_str_mv Lagunas, Anna
Martínez Fraiz, Elena
Samitier i Martí, Josep
author Lagunas, Anna
author_facet Lagunas, Anna
Martínez Fraiz, Elena
Samitier i Martí, Josep
author_role author
author2 Martínez Fraiz, Elena
Samitier i Martí, Josep
author2_role author
author
dc.subject.none.fl_str_mv Diferenciació cel·lular
Morfologia (Biologia)
Cell diferentiation
Morphology (Biology)
topic Diferenciació cel·lular
Morfologia (Biologia)
Cell diferentiation
Morphology (Biology)
description Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, we review some of the most recent examples in which gradients have been used to evaluate the effect of a varying ligand concentration in cell adhesion, morphology, growth, and differentiation of cells, including some of our recent findings. They show the importance of the organization of ligands at the nanoscale, which is highlighted by abrupt changes in cell behavior at critical concentration thresholds.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/121073
url https://hdl.handle.net/2445/121073
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fbioe.2015.00132
Frontiers in Bioengineering and Biotechnology, 2015, vol. 3, num. 132
https://doi.org/10.3389/fbioe.2015.00132
info:eu-repo/grantAgreement/EC/H2020/634928
dc.rights.none.fl_str_mv cc-by (c) Lagunas, Anna et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Lagunas, Anna et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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